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P323L mutations in SARS-CoV-2 are highly predictive of the emergence of new variants

In a new study, findings suggest that in some cases, tracking the distribution and frequency of SARS-CoV-2 minor variant genomes at a population level would help in predicting the emergence of a new dominant viral genome sequence.

30 Dec 2021

Study explores relative reproduction of the SARS-CoV-2 omicron variant in South Africa

A new study, focused on the SARS-CoV-2 Omicron variant, presented a modeling result from an analysis of genome surveillance data in Gauteng province, South Africa, using an existing estimation technique.

30 Dec 2021

Booster doses of mRNA vaccines improve humoral immunogenicity in patients with inflammatory bowel disease

Researchers evaluated the humoral immunogenicity of a third COVID-19 mRNA vaccine dose in patients with inflammatory bowel disease.

30 Dec 2021

An integrated computational methodology for COVID drug prioritization

Researchers recently published a study in the journal Briefings in Bioinformatics wherein they integrated multiple bioinformatics and cheminformatics-based methods to prioritize drugs for the treatment of COVID-19.

29 Dec 2021

Omicron analysis shows no clear evidence for increased virulence or lethality

Researchers conducted a genomic sequencing and epidemiological correlation analysis of the SARS-CoV-2 Omicron variant.

29 Dec 2021

At least 3 exposures to vaccine or virus needed for minimum protection against SARS-CoV-2 Omicron

Researchers determine the serum neutralizing and binding activity against the SARS-CoV-2 Omicron variant in individuals with different levels of immunity.

29 Dec 2021

Researchers suggest hybrid convalescent plasma therapy neutralizes the omicron variant

New research suggests convalescent plasma from unvaccinated donors is not effective against the Omicron variant, however, “hybrid” convalescent plasma from donors who recovered from COVID-19 infection and are vaccinated provides considerable antibody protection.

29 Dec 2021

Animal study suggests Omicron is less infectious than previous SARS-CoV-2 strains

A new study suggests the Omicron (B.1.1.529) variant is not as infectious as scientists initially assumed.

29 Dec 2021

Study suggests saliva swabs may be more suitable for omicron detection

New study findings reveal that saliva samples are more useful than mid-turbinate samples for the accurate detection of omicron infection.

29 Dec 2021

Impact of an omicron outbreak at a private gathering in the Faroe Islands

New findings suggest that the Omicron variant has potent immune-escape capabilities, putting even newly boosted patients at risk of infection.

29 Dec 2021

Exploring immunogenicity and safety after a homologous booster dose of SARS-CoV-2 recombinant spike protein vaccine

Research suggests that a single booster dose of NVX-CoV2373 given approximately six months after the primary series induced significant increases in humoral antibodies, while also exhibiting an acceptable safety profile.

29 Dec 2021

Booster dose of mRNA vaccines found crucial in protecting against SARS-CoV-2 Omicron variants

A new study shows that Omicron is more infectious than any of the other variants and that booster vaccines, especially mRNA vaccines, are capable of neutralizing Omicron variants of pseudoviruses.

29 Dec 2021

Estimating the epidemic potential of SARS-CoV-2 Omicron variant in South Korea

Researchers in South Korea and France have conducted an analysis on individuals infected with Omicron variant (B.1.1.529) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to estimate the epidemic potential and long-term prospects of this virus in circulation. They have found that the basic reproduction number (R0) for this variant is 1.90, while the mean serial interval is 2.22 days.

28 Dec 2021

Researchers investigate the effect of emerging SARS-CoV-2 mutations on ACE2 binding

Now in new research, scientists from the University of Leicester have been investigating how these mutations alter the affinities of RBDs to ACE2.

28 Dec 2021

SARS-CoV-2 infection induces robust and cross-reactive immune responses in children

Researchers compare the convalescent humoral and cellular immune responses between children and adults infected with SARS-CoV-2.

28 Dec 2021

Study highlights importance of positive and negative selection in evolution of SARS-CoV-2 variants

Researchers from the University of Colorado Anschutz Medical Campus have been investigating the changes imparted on the Gamma variant by three RBD mutations.

28 Dec 2021

Third BNT162b2 dose effectively neutralizes SARS-CoV-2 Omicron pseudovirus

The findings reveal that the Omicron neutralizing titers induced by the third vaccine dose are comparable to that achieved against the original Wuhan strain (wild-type SARS-CoV-2) by the two-dose regimen. The study is currently available on the medRxiv* preprint server while awaiting peer review.

28 Dec 2021

Study suggests spike mutation makes SARS-CoV-2 Omicron milder

The Omicron spike is relatively poorly cleaved and impaired in mediating cell-cell fusion and syncytia formation, contrary to predictions.

28 Dec 2021

Researchers discover antibodies that neutralize omicron and other SARS-CoV-2 variants

An international team of scientists have identified antibodies that neutralize omicron and other SARS-CoV-2 variants. These antibodies target areas of the virus spike protein that remain essentially unchanged as the viruses mutate.

28 Dec 2021

SARS-CoV-2 Alpha variant mutated to evade the immune system

The SARS-CoV-2 Alpha (B.1.1.7) variant mutated to evade our 'innate immune system', helping establish it as the world's first 'Variant of Concern', finds a new study led by researchers at UCL and the Quantitative Biosciences Institute, University of California San Francisco.

24 Dec 2021

Spike Protein News and Research

P323L mutations in SARS-CoV-2 are highly predictive of the emergence of new variants

Study explores relative reproduction of the SARS-CoV-2 omicron variant in South Africa

Booster doses of mRNA vaccines improve humoral immunogenicity in patients with inflammatory bowel disease

An integrated computational methodology for COVID drug prioritization

Omicron analysis shows no clear evidence for increased virulence or lethality

At least 3 exposures to vaccine or virus needed for minimum protection against SARS-CoV-2 Omicron

Researchers suggest hybrid convalescent plasma therapy neutralizes the omicron variant

Animal study suggests Omicron is less infectious than previous SARS-CoV-2 strains

Study suggests saliva swabs may be more suitable for omicron detection

Impact of an omicron outbreak at a private gathering in the Faroe Islands

Exploring immunogenicity and safety after a homologous booster dose of SARS-CoV-2 recombinant spike protein vaccine

Booster dose of mRNA vaccines found crucial in protecting against SARS-CoV-2 Omicron variants

Estimating the epidemic potential of SARS-CoV-2 Omicron variant in South Korea

Researchers investigate the effect of emerging SARS-CoV-2 mutations on ACE2 binding

SARS-CoV-2 infection induces robust and cross-reactive immune responses in children

Study highlights importance of positive and negative selection in evolution of SARS-CoV-2 variants

Third BNT162b2 dose effectively neutralizes SARS-CoV-2 Omicron pseudovirus

Study suggests spike mutation makes SARS-CoV-2 Omicron milder

Researchers discover antibodies that neutralize omicron and other SARS-CoV-2 variants

SARS-CoV-2 Alpha variant mutated to evade the immune system

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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