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Breakthrough study: inhibiting USP30 gene offers hope in treating Parkinson’s disease

Whether USP30 inhibition can serve as a disease-modifying therapy for Parkinson's disease (PD).

15 Nov 2023

Cannabis shows promise in easing endometriosis pain, new research suggests

The Journal of Clinical Medicine review explores cannabis as a self-management strategy for endometriosis pain, revealing its potential to reduce gut inflammation and improve gut permeability, thereby alleviating bloating and suppressing pain through interactions with the endocannabinoid system and gut microbiota.

14 Nov 2023

Gene therapy for rare diseases: A decade of progress and remaining challenges

A new review article in the peer-reviewed journal Human Gene Therapy summarizes the significant milestones in the development of gene therapy medicinal products that have facilitated the treatment of a significant number of rare diseases.

14 Nov 2023

KAIST researchers develop an IV needle that irreversibly softens upon insertion

Intravenous (IV) injection is a method commonly used in patient's treatment worldwide as it induces rapid effects and allows treatment through continuous administration of medication by directly injecting drugs into the blood vessel.

13 Nov 2023

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

A prospective path for allogeneic cellular immunotherapies.

13 Nov 2023

UCI researchers discover gene critical for muscle repair

University of California, Irvine researchers have identified a gene expressed during regeneration that is critical for muscle repair.

12 Nov 2023

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

In this study, researchers harnessed crowdsourcing and open science to develop new antivirals against SARS-CoV-2, focusing on its main protease, Mpro. Their approach led to the discovery of potent compounds, including one with high efficacy in cell lines and cross-reactivity against various COVID-19 variants, demonstrating the potential of collaborative and transparent drug discovery in tackling global health crises.

12 Nov 2023

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Research explores the advancements, challenges, and economic implications of gene therapy for various diseases, including inherited blood disorders, malignancies treated with CAR-T cells, and diseases targeted by in vivo AAV vectors. The review highlights the transformative potential of gene therapies while acknowledging the complexities in manufacturing, safety, efficacy, and long-term durability.

12 Nov 2023

Preclinical discovery could point the way toward better treatments for type 2 diabetes

A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes, according to a new study by Weill Cornell Medicine investigators.

9 Nov 2023

New device could keep implantable "living pharmacy" cells alive for months

In 2021, a Northwestern University-led research team received a Defense Advanced Research Projects Agency (DARPA) contract worth up to $33 million to develop an implantable "living pharmacy" to control the human body's sleep/wake cycles.

9 Nov 2023

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Researchers at the Centre for Genomic Regulation and Vall d'Hebron Institute of Oncology have shown that the simultaneous inhibition of two different proteins may represent a new strategy for tackling triple-negative breast cancer, the most aggressive and drug-resistant form of breast cancer.

8 Nov 2023

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

Researchers discover the BA.2.86 Omicron lineage with higher transmission potential than current dominant strains, yet show that existing antivirals remain effective. Despite its higher infectivity, BA.2.86 exhibits lower pathogenicity in hamsters, indicating decreased replication capacity may lead to less severe infections.

7 Nov 2023

Scientists develop tissue adhesive gelatin hydrogels to speed up wound healing, prevent infections

Open wounds, whether caused by accidents or from medical procedures like surgery, require proper management to speed up healing and prevent infections.

6 Nov 2023

Experimental wireless pacemaker harvests energy from heart to recharge battery

By converting mechanical energy into electrical energy, an experimental wireless, or leadless, pacemaker housing is able to partially recharge its battery, according to a proof-of-principle study to be presented at the American Heart Association's Scientific Sessions 2023.

6 Nov 2023

TIMP2 protein identified as key player in brain plasticity and memory

Researchers explored the molecular and cellular processes regulated by tissue inhibitor of metalloproteinases-2 (TIMP2) in the extracellular matrix (ECM) of the adult brain hippocampus.

6 Nov 2023

Researchers develop new OCT method to directly image cilia dynamics in living organisms

Researchers have developed a new optical coherence tomography (OCT) approach that can directly image coordination of tiny hair-like structures known as motile cilia in their natural environment.

2 Nov 2023

Mast cell receptor linked to alcohol withdrawal-associated headaches

Researchers investigate the role of the mast-cell-specific receptor Mas-related G-protein-coupled receptor B2 (MrgprB2) in alcohol-withdrawal-induced headaches.

2 Nov 2023

Seaweed symbionts reveal treasure trove of potential drug compounds

Marine macroalgae-associated Bacillota reveal a trove of bioactive compounds with potential pharmacological benefits, from antibacterial to anticancer properties. This comprehensive review illuminates the promising yet underexplored therapeutic applications of these marine microorganisms.

1 Nov 2023

Fungi used to produce food products have potential probiotic effects on gut inflammation

Many fungus strains have been used and selected by the food industry for their capacities to ferment, produce flavors or produce heterologous molecules.

26 Oct 2023

From Mount Everest to your liver: The alarming reach of 'forever chemicals' in our environment and health

Research paper provides a comprehensive review of per- and polyfluoroalkyl substances (PFAS), exploring their environmental prevalence, human exposure risks, and liver toxicity. The study highlights urgent gaps in PFAS research and calls for more studies to better understand these 'forever chemicals' and their impact on human health.

26 Oct 2023

in vivo News and Research

Breakthrough study: inhibiting USP30 gene offers hope in treating Parkinson’s disease

Cannabis shows promise in easing endometriosis pain, new research suggests

Gene therapy for rare diseases: A decade of progress and remaining challenges

KAIST researchers develop an IV needle that irreversibly softens upon insertion

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

UCI researchers discover gene critical for muscle repair

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Preclinical discovery could point the way toward better treatments for type 2 diabetes

New device could keep implantable "living pharmacy" cells alive for months

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

Scientists develop tissue adhesive gelatin hydrogels to speed up wound healing, prevent infections

Experimental wireless pacemaker harvests energy from heart to recharge battery

TIMP2 protein identified as key player in brain plasticity and memory

Researchers develop new OCT method to directly image cilia dynamics in living organisms

Mast cell receptor linked to alcohol withdrawal-associated headaches

Seaweed symbionts reveal treasure trove of potential drug compounds

Fungi used to produce food products have potential probiotic effects on gut inflammation

From Mount Everest to your liver: The alarming reach of 'forever chemicals' in our environment and health

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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