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Abbott's investigational anti-interleukin-12 fully human monoclonal antibody in Crohn's disease study

Results of a Phase II study of Abbott's ABT-874, a fully human anti-interleukin-12 (IL-12) monoclonal antibody, will appear tomorrow in the New England Journal of Medicine citing treatment with ABT-874 shows differences in response and remission in patients with active Crohn's disease compared to placebo, in one arm of the study.

10 Nov 2004

Dietary supplement DHEA could play a role in reducing abdominal fat in elderly men and women

Preliminary research indicates that the dietary supplement DHEA could play a role in reducing abdominal fat in elderly men and women with age-related decreases in DHEA levels, according to a study in the November 10 issue of JAMA.

10 Nov 2004

Calcium channel blocker reduces adverse cardiovascular events

The calcium channel blocker amlodipine decreases the risk of cardiovascular events (such as heart attack or heart-disease related deaths) in patients with coronary artery disease and normal blood pressure, as does the ACE inhibitor enalapril, but to a lesser extent, according to a study in the November 10 issue of JAMA.

10 Nov 2004

A new medication has dramatically reduced mortality among African-American patients suffering from heart disease

A new medication has dramatically reduced mortality among African-American patients suffering from heart disease, according to results of a study including UT Southwestern Medical Center at Dallas researchers.

9 Nov 2004

Zetia co-administered with Fenofibrate significantly reduced LDL ("bad") cholesterol in mixed hyperlipidemia patients

Results from a new study showed that coadministration of Zetia (ezetimibe) and fenofibrate significantly reduced LDL ("bad") cholesterol (LDL-C), non-high density lipoprotein cholesterol (non-HDL-C) and apo B1 in patients with mixed hyperlipidemia and high LDL cholesterol when compared to fenofibrate alone.

9 Nov 2004

BiDil demonstrates significant improvement in survival rates in African American heart failure patients

"African Americans suffer disproportionately from heart failure and until A-HeFT have been underrepresented in heart failure trials," said Malcolm Taylor, M.D., Chair of the Association of Black Cardiologists Committee on Heart Failure. "A-HeFT represents a significant step forward in addressing these disparities."

9 Nov 2004

ACE inhibitors not needed for many heart disease patients

Many heart disease patients who are already receiving state-of-the-art therapy do not benefit from additional treatment with angiotensin converting enzyme (ACE) inhibitors, according to results of a new study funded by the National Heart, Lung, and Blood Institute (NHLBI).

8 Nov 2004

Antidepressants may help people quit smoking when used in conjunction with nicotine patches

When used with a transdermal nicotine patch, nortriptyline—an antidepressant medication—may aid in smoking cessation, according to an article in the November 8 issue of The Archives of Internal Medicine, one of the JAMA/Archives journals.

8 Nov 2004

Reviparin significantly reduces death and repeat heart attacks without increasing the risk of stroke

A major Canadian-led global study has found that an inexpensive anti-blood-clotting drug significantly reduces death and repeat heart attacks without increasing the risk of stroke.

8 Nov 2004

D-cycloserine (DCS), used in concert with psychotherapy, is an effective treatment for some anxiety-related disorders

A tuberculosis drug called D-cycloserine (DCS), used in concert with psychotherapy, is an effective treatment for some anxiety-related disorders, according to research by scientists at Emory University School of Medicine and the Center for Behavioral Neuroscience (CBN).

8 Nov 2004

Atenolol beta-blocker may not be effective in reducing heart attacks

A study published in this weeks issue of THE LANCET suggest that atenolol - one of the most widely prescribed beta-blockers for reducing blood pressure - may not be effective in reducing heart attacks or death from cardiovascular causes.

5 Nov 2004

Trial of new type of drug that attacks amyloid

Neuroscientists at the Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia will begin a clinical trial testing a new type of drug that attacks amyloid, the protein substance that accumulates in the brains of Alzheimer’s disease patients.

4 Nov 2004

Quitting smoking can be made easier with long-term comprehensive drug and psychological interventions

People who want to quit smoking have an improved chance of success if they receive long-term comprehensive drug and psychological interventions, according to a new study by UCSF researchers.

4 Nov 2004

Study of infection prevention therapy for premature babies

Whether donated human antibodies can protect premature babies from a common and potentially dangerous bacterial infection is under study at the Medical College of Georgia Children’s Medical Center.

4 Nov 2004

Psoriasis trial enters final stage

Solbec Pharmaceuticals Ltd today announced the successful completion of the first two stages of the Phase I clinical trial of its lead compound, CoramsineTM (SBP002), for the treatment of psoriasis.

4 Nov 2004

High-dose statin therapy for aggressive cholesterol-lowering outperforms typical care

Patients treated with high doses of atorvastatin had about a one percent lower annual rate of heart attacks than similar patients receiving usual care, according to a new study in the Nov. 2, 2004 issue of the Journal of the American College of Cardiology.

2 Nov 2004

Reproductive hormones have effects on all of these stages of brain growth and development

Scientists are now uncovering increasing evidence that the brain not only responds to hormones produced by the reproductive system, but that these hormones-the so-called "female hormones," estrogen and progestin, and the "male" androgens, such as testosterone-play an important role in the development of differences between male and female brains.

2 Nov 2004

Researcher finds no long-term benefit of using glucosamine for knee joint pain

A popular food supplement used to treat osteoarthritis pain in knee joints has been shown to have no long-term beneficial effect, according to a national study conducted by a University of British Columbia post-doctoral fellow working at the Arthritis Research Centre of Canada

1 Nov 2004

Do cholesterol-reducing drugs decrease the risk of heart attacks and strokes in diabetics?

International researchers will, for the first time, present findings from the landmark 4D trial about whether a cholesterol-reducing drug decreases the risk of heart attacks and strokes with type 2 diabetics on dialysis at the American Society of Nephrology’s 37th Annual Meeting and Scientific Exposition in St. Louis, Missouri.

1 Nov 2004

Gel significantly increases sexual activity in surgically menopausal women

BioSante Pharmaceuticals today announced the presentation of new Phase II clinical data on LibiGel™ (transdermal testosterone gel) at the International Society for the Study of Women's Sexual Health (ISSWSH) Annual Meeting in Atlanta.

1 Nov 2004

Placebo News and Research

Abbott's investigational anti-interleukin-12 fully human monoclonal antibody in Crohn's disease study

Dietary supplement DHEA could play a role in reducing abdominal fat in elderly men and women

Calcium channel blocker reduces adverse cardiovascular events

A new medication has dramatically reduced mortality among African-American patients suffering from heart disease

Zetia co-administered with Fenofibrate significantly reduced LDL ("bad") cholesterol in mixed hyperlipidemia patients

BiDil demonstrates significant improvement in survival rates in African American heart failure patients

ACE inhibitors not needed for many heart disease patients

Antidepressants may help people quit smoking when used in conjunction with nicotine patches

Reviparin significantly reduces death and repeat heart attacks without increasing the risk of stroke

D-cycloserine (DCS), used in concert with psychotherapy, is an effective treatment for some anxiety-related disorders

Atenolol beta-blocker may not be effective in reducing heart attacks

Trial of new type of drug that attacks amyloid

Quitting smoking can be made easier with long-term comprehensive drug and psychological interventions

Study of infection prevention therapy for premature babies

Psoriasis trial enters final stage

High-dose statin therapy for aggressive cholesterol-lowering outperforms typical care

Reproductive hormones have effects on all of these stages of brain growth and development

Researcher finds no long-term benefit of using glucosamine for knee joint pain

Do cholesterol-reducing drugs decrease the risk of heart attacks and strokes in diabetics?

Gel significantly increases sexual activity in surgically menopausal women

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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