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Asthma breakthrough: potential cause and corrective treatment are identified

A paper published yesterday in Science Translational Medicine reports that the root cause of asthma has been found and a potential treatment to reverse all symptoms has been proposed...

24 Apr 2015

Alternative treatment options for uterine fibroids

A 47-year-old African-American woman has heavy menstrual bleeding and iron-deficiency anemia. She reports the frequent need to urinate during the night and throughout the day. A colonoscopy is negative and an ultrasonography shows a modestly enlarged uterus with three uterine fibroids, noncancerous growths of the uterus.

24 Apr 2015

Penn researchers find molecular bond between DNA damage, cellular senescence and premature aging

Like a beloved pair of jeans, human DNA accumulates damage over time, and older people's bodies can't repair it as well. Many scientists believe a build up of damage can cause cells to enter an irreversible dormant state known as senescence. Cellular senescence is believed to be responsible for some of the telltale signs of aging, such as weakened bones, less resilient skin and slow-downs in organ function.

24 Apr 2015

Cardiff scientists make breakthrough asthma discovery

Cardiff University scientists have for the first time identified the potential root cause of asthma and an existing drug that offers a new treatment.

24 Apr 2015

Cardiff scientists identify potential root cause of asthma and highlight new treatment option

Cardiff University scientists have for the first time identified the potential root cause of asthma and an existing drug that offers a new treatment.

23 Apr 2015

Scientists reveal how breast milk prevents necrotizing enterocolitis in premature babies

The immune-boosting properties of breast milk have long been known. Now a team of scientists led by Johns Hopkins pediatric surgeon-in-chief David Hackam, M.D., Ph.D., says experiments in mice reveal how breast milk works to ward off the development of necrotizing enterocolitis (NEC), a devastating intestinal disorder that affects 12 percent of premature babies and claims the lives of one in four of those who have it.

23 Apr 2015

Researchers explore evolution of eardrums

Researchers at the RIKEN Evolutionary Morphology Laboratory and the University of Tokyo in Japan have determined that the eardrum evolved independently in mammals and diapsids--the taxonomic group that includes reptiles and birds. Published in Nature Communications, the work shows that the mammalian eardrum depends on lower jaw formation, while that of diapsids develops from the upper jaw.

22 Apr 2015

Botanical formula improves effect of tamoxifen drug in ER+ human breast cancer

Researchers at the Cancer Research Laboratory, Methodist Research Institute, Indiana University Health found that a botanical formula for breast health inhibited the growth of estrogen receptor-positive (ER+) human breast cancer cells. More importantly, the researchers also found that the formula enhanced the anti-cancer benefits of the drug tamoxifen in the treatment of breast cancer.

22 Apr 2015

Honokiol extract holds promise as adjunct treatment for bladder and kidney cancers

The botanical extract honokiol, a biologically active molecule isolated from the bark of Magnolia spp., holds promise as an adjunct treatment for aggressive bladder and kidney cancers, as reported in two new studies. New research on honokiol in bladder cancer was presented at the American Association for Cancer Research Annual Meeting 2015.

22 Apr 2015

Neuroscientists identify novel brain circuitry that increases anxiety during nicotine withdrawal

In a promising breakthrough for smokers who are trying to quit, neuroscientists at the University of Massachusetts Medical School and The Scripps Research Institute have identified circuitry in the brain responsible for the increased anxiety commonly experienced during withdrawal from nicotine addiction.

22 Apr 2015

New class of drugs targeting blood glucose level could benefit individuals with type 2 diabetes

Individuals with type 2 diabetes, who are resistant to insulin, have an excess blood glucose level, which they are now trying to reduce using a new class of diabetes drugs known as the gliflozins.

22 Apr 2015

Cardio3 BioSciences reports absence of short term adverse events in first patient following NKG2D CAR T-cell infusion

Cardio3 BioSciences, soon to be renamed Celyad, a leader in engineered cell-therapy treatments today announced the infusion of the first patient enrolled in the Company’s Phase I clinical trial evaluating the safety and feasibility of its NKG2D CAR T-cell therapy, in cancer patients suffering from acute myeloid leukemia (AML) or multiple myeloma (MM).

22 Apr 2015

Data presented at AACR 2015 recognizes value of EKF PointMan technology for assessing lung cancer mutation status

The PointMan EGFR DNA enrichment kit, a novel method for selective amplification of genotype specific sequences.

From EKF Diagnostics 21 Apr 2015

New combination therapy could overcome treatment resistance, relapse in breast cancer

Researchers from The University of Manchester working with drug development company Evgen Pharma, have developed a new combination of drugs which could overcome treatment resistance and relapse in breast cancer.

21 Apr 2015

Designing AR Inhibitors Team wins AACR Team Science Award for developing prostate cancer treatment

The American Association for Cancer Research will award the ninth annual AACR Team Science Award to the Designing Androgen Receptor (AR) Inhibitors Team from Memorial Sloan Kettering Cancer Center and the University of California, Los Angeles at the AACR Annual Meeting 2015, to be held in Philadelphia, April 18-22.

21 Apr 2015

Experimental immune therapy generally safe, well-tolerated in women with triple-negative breast cancer

Early data in a preliminary human study show that an experimental immune system drug is generally safe and well tolerated in women with metastatic, triple-negative breast cancer, a persistently difficult form of the disease to treat.

21 Apr 2015

New drug combination shows promise in patients with metastatic melanoma

Once again, researchers at Penn's Abramson Cancer Center have extended the reach of the immune system in the fight against metastatic melanoma, this time by combining the checkpoint inhibitor tremelimumab with an anti-CD40 monoclonal antibody drug.

20 Apr 2015

Penn professor to be recognized with AACR-CRI Lloyd J. Old Award in Cancer Immunology

The American Association for Cancer Research and the Cancer Research Institute will recognize Carl H. June, MD, the Richard W. Vague professor in immunotherapy at the Perelman School of Medicine and director of the Center for Cellular Immunotherapies at the University of Pennsylvania in Philadelphia, with the third annual AACR-CRI Lloyd J. Old Award in Cancer Immunology at the AACR Annual Meeting 2015, to be held in Philadelphia, April 18-22.

20 Apr 2015

Study: 1 in 4 patients with advanced lung cancer does not receive EGFR test results before treatment

Almost one in four patients (24%) with advanced lung cancer in Europe, Asia and the US are not receiving EGFR test results before being started on treatment, researchers report at the European Lung Cancer Conference.

20 Apr 2015

James Allison to be honored with 2015 Pezcoller Foundation-AACR International Award for Cancer Research

The 2015 Pezcoller Foundation-American Association for Cancer Research (AACR) International Award for Cancer Research will be presented to James P. Allison, PhD, at the AACR Annual Meeting 2015, to be held in Philadelphia, April 18-22.

17 Apr 2015

Receptor News and Research

Asthma breakthrough: potential cause and corrective treatment are identified

Alternative treatment options for uterine fibroids

Penn researchers find molecular bond between DNA damage, cellular senescence and premature aging

Cardiff scientists make breakthrough asthma discovery

Cardiff scientists identify potential root cause of asthma and highlight new treatment option

Scientists reveal how breast milk prevents necrotizing enterocolitis in premature babies

Researchers explore evolution of eardrums

Botanical formula improves effect of tamoxifen drug in ER+ human breast cancer

Honokiol extract holds promise as adjunct treatment for bladder and kidney cancers

Neuroscientists identify novel brain circuitry that increases anxiety during nicotine withdrawal

New class of drugs targeting blood glucose level could benefit individuals with type 2 diabetes

Cardio3 BioSciences reports absence of short term adverse events in first patient following NKG2D CAR T-cell infusion

Data presented at AACR 2015 recognizes value of EKF PointMan technology for assessing lung cancer mutation status

New combination therapy could overcome treatment resistance, relapse in breast cancer

Designing AR Inhibitors Team wins AACR Team Science Award for developing prostate cancer treatment

Experimental immune therapy generally safe, well-tolerated in women with triple-negative breast cancer

New drug combination shows promise in patients with metastatic melanoma

Penn professor to be recognized with AACR-CRI Lloyd J. Old Award in Cancer Immunology

Study: 1 in 4 patients with advanced lung cancer does not receive EGFR test results before treatment

James Allison to be honored with 2015 Pezcoller Foundation-AACR International Award for Cancer Research

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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