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USC receives $6 million grant for pioneering glioblastoma gene therapy

The California Institute for Regenerative Medicine has awarded a $6 million grant to USC investigators pioneering a new first-of-its-kind genetic therapy for glioblastoma, a severe form of brain cancer.

3 Feb 2025

Study uncovers two inhibitors to halt metaplastic breast cancer progression

A national study seeking more effective treatment for deadly metaplastic breast cancer has identified two inhibitor drugs with the potential to interrupt disease progression.

3 Feb 2025

Researchers discover key to boosting thymus regeneration after damage

A team of international researchers led by scientists at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States, with its National Medical Center in Los Angeles ranked among the nation's top 5 cancer centers by U.S. News & World Report, have demonstrated a way to boost thymic function after damage in preclinical studies.

3 Feb 2025

Single heat stroke exposure triggers long-term health risks and metabolic vulnerabilities

The study links exertional heat stroke to chronic disorders, revealing impacts on body mass regulation and heart health, especially in high-fat diet scenarios.

3 Feb 2025

Could a handful of nuts a day prevent cognitive decline?

A new study suggests that a daily handful of nuts could help protect brain function in older adults, potentially reducing cognitive decline and supporting long-term mental sharpness.

2 Feb 2025

UIC scientists redesign asparaginase to minimize leukemia treatment side effects

University of Illinois Chicago scientists have redesigned a treatment for the most common pediatric leukemia to eliminate its severe side effects, like blood clots and liver damage.

31 Jan 2025

Breakthrough model simulates human bone marrow function in the lab

Hidden within our bones, marrow sustains life by producing billions of blood cells daily, from oxygen-carrying red cells to immune-boosting white cells.

31 Jan 2025

Targeting MYCN and MDM2 offers new hope for cancer therapy

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

29 Jan 2025

New compound Z526 combats cancer-associated cachexia in preclinical models

In a recent study, researchers demonstrated that Z526, a novel dithiocarbamate-like compound, mitigates cancer-associated cachexia (CAC) both in vitro and in vivo.

29 Jan 2025

Researchers identify brain circuit to reduce anxiety without side effects

Weill Cornell Medicine investigators have identified in a preclinical model a specific brain circuit whose inhibition appears to reduce anxiety without side effects.

28 Jan 2025

New treatment identified for peripheral nerve sheath tumors

A multicenter collaboration led by the Bellvitge Biomedical Research Institute (IDIBELL) - Institut Català d'Oncologia (ICO) and the Germans Trias i Pujol Research Institute (IGTP) identified a potential new treatment for an aggressive sarcoma arising in the nerves.

28 Jan 2025

Study unveils critical insights in understanding post-traumatic epilepsy

A new international study has unveiled critical insights in understanding post-traumatic epilepsy (PTE), a condition that can develop following traumatic brain injury. Led by researchers at FutureNeuro, the Research Ireland Centre for Translational Brain Science and RCSI University of Medicine and Health Sciences and published in Theranostics, the study highlights the important role played by a receptor in the brain called P2X7.

27 Jan 2025

Global cannabis boom brings unexpected cardiovascular risks to light

This review examines the cardiovascular risks associated with cannabis, revealing its potential to cause severe heart health issues and inform public policy.

27 Jan 2025

New light-based technique could transform heart tissue repair

Researchers from Mass General Brigham and collaborating institutions have developed a non-invasive approach to manipulate cardiac tissue activity by using light to stimulate an innovative ink incorporated into bioprinted tissue.

24 Jan 2025

Breakthrough gene discovery offers new hope for medulloblastoma therapy

Scientists at The Hospital for Sick Children (SickKids) have identified a key gene that could lead to next-generation treatments for medulloblastoma, the most common malignant brain tumor in children.

24 Jan 2025

NUS researchers develop DNA barcoded nanoparticles for targeted cancer therapy

A team of researchers from the National University of Singapore (NUS) has developed a novel method to enhance the precision of cancer treatment using gold nanoparticles tagged with DNA barcodes.

24 Jan 2025

Review highlights the role of mitochondrial Ca2+ imbalance in neurodegenerative diseases

Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen species (ROS) management and Ca2+ signaling.

24 Jan 2025

New approach to treating ependymoma with leukemia drug

Rakesh Jain PhD, Director of the E.L. Steele Laboratories for Tumor Biology at Massachusetts General Hospital and A. Werk Cook Professor of Radiation Oncology at Harvard Medical School, is senior author of a new study in PNAS, Targeting EPHB2/ABL1 Restores Anti-Tumor Immunity in Preclinical Models of Ependymoma.

23 Jan 2025

Researchers investigate a new combination therapy against cancer

A research team at the Medical University of Vienna led by Maria Sibilia has investigated a new combination therapy against cancer.

23 Jan 2025

Insilico Medicine doses first patient in Phase I Trial of ISM6331 for mesothelioma

Insilico Medcine( "Insilico") , a clinical stage generative artificial intelligence (AI)-driven biotechnology company today announced the first patient has been dosed in the global multicenter Phase I Trial of ISM6331, a novel pan-TEAD inhibitor developed from Insilico's generative chemistry engine Chemistry42, for the treatment of mesothelioma and other solid tumors.

22 Jan 2025