Efficacy News and Research

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Tailored dose-dense chemotherapy does not improve breast cancer recurrence-free survival

Among women with high-risk early breast cancer, the use of tailored dose-dense chemotherapy compared with standard adjuvant chemotherapy did not result in a statistically significant improvement in breast cancer recurrence-free survival, and nonhematologic toxic effects were more frequent in the tailored dose-dense group, according to a study appearing in the November 8 issue of JAMA.

8 Nov 2016

Nutrient-fortified donor milk does not improve neurodevelopment in VLBW babies, study finds

Among very low-birth-weight (VLBW) infants, the use of supplemental donor milk compared with formula did not improve neurodevelopment at 18 months, according to a study appearing in the November 8 issue of JAMA.

8 Nov 2016

Caltech researchers develop new technique that increases safety of TCR gene therapy

The human body produces T cells to recognize and fight disease. Each T cell has a unique T cell receptor (or TCR) on its surface that surveils small fragments of proteins presented by other cells.

8 Nov 2016

Scientists turn iron-scavenging power against common UTI-causing bacteria

For most invading bacteria, the bladder is not a friendly place. But for those that have figured out how to scavenge iron from their hosts, it's a fine place to grow and reproduce.

7 Nov 2016

Biologic drugs may help prevent progressive bone loss in patients with RA

A new review by the International Osteoporosis Foundation Chronic Inflammation and Bone Structure Working Group concludes that early and aggressive treatment of Rheumatoid Arthritis (RA) with biologic drugs, specifically biological disease-modifying anti-rheumatic drugs (DMARDs), may be most effective in halting progressive bone loss in patients with RA.

7 Nov 2016

New treatment with therapeutic short interfering RNA could help thwart cancer

In the fight against cancer, doctors dish out combination-blows of surgery, chemotherapy and other drugs to beat back a merciless foe. Now, scientists have taken early steps toward adding a stinging punch to clinicians' repertoire.

7 Nov 2016

Combination of immunotherapy treatments can improve survival in patients with advanced skin cancer

McMaster University researchers have found that for patients diagnosed in the late stages of one of the most common and deadly forms of skin cancer, treatment with a combination of immunotherapy options improves survival and lowers the risk of life-threatening events.

7 Nov 2016

FDA approves expanded use of systemic therapy for treating chronic moderate-to-severe pediatric psoriasis

Amgen today announced that the U.S. Food and Drug Administration has approved the supplemental Biologics License Application for the expanded use of ENBREL (etanercept), making it the first and only systemic therapy to treat pediatric patients (ages 4-17) with chronic moderate-to-severe plaque psoriasis.

7 Nov 2016

Combination of immunotherapy options improves survival of patients with deadly forms of skin cancer

5 Nov 2016

Researchers to study integration of diabetes, hypertension screening into HIV screening

The success of HIV treatment programs depends upon the identification, enrollment, and retention of HIV-infected individuals, but public health officials have learned that there are numerous barriers to such success at every point in this care continuum.

5 Nov 2016

Stem cell therapy appears to dampen the body's neuroinflammatory response to trauma, preserve brain tissue

Results of a cellular therapy clinical trial for traumatic brain injury (TBI) using a patient's own stem cells showed that the therapy appears to dampen the body's neuroinflammatory response to trauma and preserve brain tissue, according to researchers at The University of Texas Health Science Center at Houston.

4 Nov 2016

Ebola mutation increased infectivity

New research finds a genetic mutation in the Ebola virus that enabled it to target human cells more effectively during the recent Ebola epidemic.

4 Nov 2016

Mount Sinai Health System introduces first enterprise-wide digital medicine care delivery system

Researchers in the Sinai App Lab at the Icahn School of Medicine at Mount Sinai have developed RxUniverse, the first enterprise-wide digital medicine care delivery system that enables physicians to digitally prescribe evidence-based mobile health applications to patients at the point of care.

3 Nov 2016

Safety of generic oncology drugs in developing countries is uncertain, say researchers

Although generic oncology drugs can reduce patient costs and improve treatment access, the safety of these drugs in developing countries is uncertain, according to an international research team led by Dr. Charles Bennett, Josie M. Fletcher professor and chairman of the S.C. SmartState Center in Medication Safety and Efficacy at the College of Pharmacy at the University of South Carolina.

3 Nov 2016

Transcatheter cerebral embolic protection effectively captures embolic debris and safe in TAVR patients

An international study has found that transcatheter cerebral embolic protection (TCEP) is safe, provides effective capture of embolic debris and does not change neurocognitive function for transcatheter aortic valve replacement (TAVR) patients.

2 Nov 2016

Using deep learning to update the drug discovery paradigm: an interview with Professor Jackie Hunter

With the current drug discovery paradigm, it takes up to 15 years to translate an idea, such as hypothesizing a certain protein is important in a disease and testing this with targeting the protein with a drug, all the way through to proof of concept...

2 Nov 2016

New review highlights promises and challenges of nanotechnology in neuroscience

Despite the numerous challenges associated with the application of nanotechnology in neuroscience, it promises to have a significant impact on our understanding of how the nervous system works, how it fails in disease, and the development of earlier and less-invasive diagnostic procedures so we can intervene in the pre-clinical stage of neurological disease before extensive neurological damage has taken place.

2 Nov 2016

Disrupted circadian rhythm may not help achieve maximum weight loss after bariatric surgery

A newly released basic science study of Roux-en-Y gastric bypass (RYGB) suggests that a functioning circadian clock, or sleeping at night and being awake during the day, can help patients achieve a higher amount of weight loss following the surgery.

2 Nov 2016

Complete removal of contamination from robotic surgical instruments may be unattainable, study shows

It is virtually impossible to remove all contamination from robotic surgical instruments, even after multiple cleanings, according to a study published today in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America.

1 Nov 2016

New study to explore therapeutic pill for treatment of concussion

The goal of finding a treatment for concussion may be one step closer due to a new study being launched by University of Miami researchers.

1 Nov 2016

Efficacy News and Research

Tailored dose-dense chemotherapy does not improve breast cancer recurrence-free survival

Nutrient-fortified donor milk does not improve neurodevelopment in VLBW babies, study finds

Caltech researchers develop new technique that increases safety of TCR gene therapy

Scientists turn iron-scavenging power against common UTI-causing bacteria

Biologic drugs may help prevent progressive bone loss in patients with RA

New treatment with therapeutic short interfering RNA could help thwart cancer

Combination of immunotherapy treatments can improve survival in patients with advanced skin cancer

FDA approves expanded use of systemic therapy for treating chronic moderate-to-severe pediatric psoriasis

Combination of immunotherapy options improves survival of patients with deadly forms of skin cancer

Researchers to study integration of diabetes, hypertension screening into HIV screening

Stem cell therapy appears to dampen the body's neuroinflammatory response to trauma, preserve brain tissue

Ebola mutation increased infectivity

Mount Sinai Health System introduces first enterprise-wide digital medicine care delivery system

Safety of generic oncology drugs in developing countries is uncertain, say researchers

Transcatheter cerebral embolic protection effectively captures embolic debris and safe in TAVR patients

Using deep learning to update the drug discovery paradigm: an interview with Professor Jackie Hunter

New review highlights promises and challenges of nanotechnology in neuroscience

Disrupted circadian rhythm may not help achieve maximum weight loss after bariatric surgery

Complete removal of contamination from robotic surgical instruments may be unattainable, study shows

New study to explore therapeutic pill for treatment of concussion

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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