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Researchers investigate ways to counteract unhealthy effects of fat

A fat yet muscular mouse is helping researchers learn whether more muscle improves the cardiovascular health of obese individuals. We are looking for ways to counteract the unhealthy effects of fat, said Dr. David Stepp, vascular biologist at the Medical College of Georgia Vascular Biology Center and co-director of MCG's Diabetes & Obesity Discovery Institute.

23 Nov 2010

New microchip implant enables people with paraplegia to exercise paralysed leg muscles

Engineers have developed a new type of microchip muscle stimulator implant that will enable people with paraplegia to exercise their paralysed leg muscles.

23 Nov 2010

Breakthrough with mutant gene that causes familial ALS

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that eventually destroys most motor neurons, causing muscle weakness and atrophy throughout the body. There is no cure and the current treatment has only a moderate effect on the march of the disease, which typically kills within three to five years. This week in PNAS, a team of Brandeis scientists reports an innovative approach to treating the most common form of familial ALS, commonly known as Lou Gehrig's disease.

23 Nov 2010

New computer method measures mechanical stress in fat cells

From fad diets to exercise programs, Americans continue to fight the battle of the bulge. Now they'll have help from recent Tel Aviv University research that has developed a new method to look at how fat cells which produce the fat in our bodies respond to mechanical loads.

23 Nov 2010

Stealth Peptides introduces Bendavia clinical candidate at AHA Scientific Sessions

Stealth Peptides, a privately held biopharmaceutical company developing innovative mitochondrial therapies for diseases with significant unmet medical needs, introduced its lead clinical candidate, Bendavia, a novel compound that targets the mitochondrion, at the 2010 American Heart Association's (AHA) Scientific Sessions, Resuscitation Science Symposium.

22 Nov 2010

VYTORIN reduces major vascular events in patients with chronic kidney disease

In a new investigational study of VYTORIN, the cholesterol-lowering medicine from Merck, VYTORIN 10/20 mg reduced the incidence of first major vascular events defined as non-fatal heart attacks or cardiac death, stroke or any revascularization procedure by a highly statistically significant 16.1 percent compared to placebo, Study of Heart and Renal Protection study involved more than 9,000 patients who, on average, had advanced or end-stage chronic kidney disease (CKD)

22 Nov 2010

SHARP study shows cholesterol-lowering effective for patients with kidney disease

Around a quarter of all heart attacks, strokes, and operations to open blocked arteries could be avoided in people with chronic kidney disease by using the combination of ezetimibe and simvastatin to lower blood cholesterol levels. That's the conclusion from the world's largest ever randomized trial in kidney disease.

22 Nov 2010

Bardoxolone methyl treatment may reduce stage of CKD, improve eGFR in kidney function

Reata Pharmaceuticals and Abbott today announced data from a Phase 2b study which suggests that bardoxolone methyl, an investigational treatment for chronic kidney disease (CKD), may reduce the stage of CKD and improve estimated glomerular filtration rate (eGFR) and other measures of kidney function in the majority of patients receiving the drug.

22 Nov 2010

New editorial dispel doubts about Lou Gehrig's ALS diagnosis

A recent study suggesting that amyotrophic lateral sclerosis (ALS) may be attributed to repetitive head trauma experienced in collision sports lacks scientific epidemiological evidence to support this claim.

20 Nov 2010

CSU invents artificial body parts that look, feel, behave, and bleed like real skin, muscles and vessels

In the last 50 years, modern medicine has made astounding advances in surgery, yet many of today's veterinary and human medicine students still hone basic surgical and suturing skills on carpet pads and pig's feet before transitioning to a live patient. An invention by Colorado State University veterinarians provides students with artificial body parts that look, feel, behave, and even bleed just like real skin, muscles and vessels.

20 Nov 2010

Simple strategies to cope with holiday stress

Dr. Richard Blonna, author, life coach, and stress management expert, offers five simple strategies for managing holiday stress. His approach to managing the worry and anxiety associated with holiday stress is adapted from his new book, Stress Less, Live More; How Acceptance and Commitment Therapy Can Help You Live a Busy Yet Balanced Life.

20 Nov 2010

Scientists discover Notch pathway may play a role in alcohol's protective effects

Many studies support the assertion that moderate drinking is beneficial when it comes to cardiovascular health, and for the first time scientists have discovered that a well-known molecule, called Notch, may be behind alcohol's protective effects. Down the road, this finding could help scientists create a new treatment for heart disease that mimics the beneficial influence of modest alcohol consumption.

20 Nov 2010

Vascular Disease Foundation urges diabetic patients to be alert about P.A.D. signs

P.A.D. occurs when arteries in the legs become narrowed or clogged with fatty deposits, reducing blood flow to the legs. This can result in leg muscle pain when walking, disability, amputation, and poor quality of life. Blocked arteries found in people with P.A.D. can be a red flag that other arteries, including those in the heart and brain, may also be blocked - increasing the risk of a heart attack or stroke.

20 Nov 2010

Platelet Rich Plasma Therapy reduces pain and improves function in knee osteoarthritis patients

The first American study that positions Platelet Rich Plasma Therapy (PRP) as a viable means in managing knee osteoarthritis, appeared today in the December issue of the American Journal of Physical Medicine & Rehabilitation (AJPMR). The study, authored by Dr. Steven Sampson of the Orthohealing Center in Los Angeles, details the account of 14 patients with primary and secondary knee osteoarthritis receiving three platelet-rich plasma injections in the affected knee at 4-week intervals with one year follow up.

20 Nov 2010

Acceleron presents ACE-041 interim results for advanced cancer at EORTC-NCI-AACR Symposium

Acceleron Pharma, Inc., a biopharmaceutical company developing novel protein therapeutics that regulate the growth and development of tissues and cells, including muscle, bone, red blood cells, and vasculature, today announced the presentation of interim results from the first-in-human clinical study of ACE-041 in patients with advanced cancer at the 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Berlin, Germany.

20 Nov 2010

Researchers develop medical model for regenerating bladders using stem cells

Researchers in the United States have developed a medical model for regenerating bladders using stem cells harvested from a patient's own bone marrow. The research, published in STEM CELLS, is especially relevant for paediatric patients suffering from abnormally developed bladders, but also represents another step towards new organ replacement therapies.

20 Nov 2010

Fifth gene defect, 47 DNA regions linked to thoracic aortic disease: Researchers

Discovery of a fifth gene defect and the identification of 47 DNA regions linked to thoracic aortic disease are the subject of studies released this month involving researchers at The University of Texas Health Science Center at Houston.

19 Nov 2010

Genetic alterations may lead to thoracic aortic disease

19 Nov 2010

NAVISTAR THERMOCOOL Catheter improves quality of life in patients with atrial fibrillation

According to data appearing today in Circulation Cardiovascular Quality and Outcomes, patients with a common heart rhythm disorder, called atrial fibrillation, who were treated with catheter ablation using the NAVISTAR THERMOCOOL Catheter, reported markedly fewer symptoms and substantially improved quality of life than patients treated with antiarrhythmia drugs at one year.

18 Nov 2010

Study finds sfrp2 protein may play a role in accelerating heart muscle repair

Heart tissue and stem cells spring into action to begin repairing muscle damaged in a heart attack, and researchers at Duke University School of Medicine found that a protein naturally produced in the body may potentially play a role in accelerating heart muscle repair.

18 Nov 2010

Muscle News and Research

Researchers investigate ways to counteract unhealthy effects of fat

New microchip implant enables people with paraplegia to exercise paralysed leg muscles

Breakthrough with mutant gene that causes familial ALS

New computer method measures mechanical stress in fat cells

Stealth Peptides introduces Bendavia clinical candidate at AHA Scientific Sessions

VYTORIN reduces major vascular events in patients with chronic kidney disease

SHARP study shows cholesterol-lowering effective for patients with kidney disease

Bardoxolone methyl treatment may reduce stage of CKD, improve eGFR in kidney function

New editorial dispel doubts about Lou Gehrig's ALS diagnosis

CSU invents artificial body parts that look, feel, behave, and bleed like real skin, muscles and vessels

Simple strategies to cope with holiday stress

Scientists discover Notch pathway may play a role in alcohol's protective effects

Vascular Disease Foundation urges diabetic patients to be alert about P.A.D. signs

Platelet Rich Plasma Therapy reduces pain and improves function in knee osteoarthritis patients

Acceleron presents ACE-041 interim results for advanced cancer at EORTC-NCI-AACR Symposium

Researchers develop medical model for regenerating bladders using stem cells

Fifth gene defect, 47 DNA regions linked to thoracic aortic disease: Researchers

Genetic alterations may lead to thoracic aortic disease

NAVISTAR THERMOCOOL Catheter improves quality of life in patients with atrial fibrillation

Study finds sfrp2 protein may play a role in accelerating heart muscle repair

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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