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Nutlin-3a molecules stimulate signal to induce cell death and senescence in brain cancer

Researchers of Apoptosis and Cancer Group of the Bellvitge Biomedical Research Institute (IDIBELL) have found that a small molecule, Nutlin-3a, an antagonist of MDM2 protein, stimulates the signalling pathway of another protein, p53.

21 Apr 2011

Hanmi granted exclusive rights to Kinex KX01 Src kinase/pretubulin dual mechanism inhibitor for oncology indications

Kinex Pharmaceuticals, LLC and Hanmi Pharmaceutical Co., Ltd. announced today the execution of a license agreement granting Hanmi Pharmaceuticals exclusive rights to their lead compound, KX01, for all oncology indications in selected Asian Territories.

21 Apr 2011

Scientists discover 'small molecule' substance that blocks cholesterol formation in the brain

A needle-in-the-haystack search through nearly 390,000 chemical compounds had led scientists to a substance that can sneak through the protective barrier surrounding the brain with effects promising for new drugs for Parkinson's and Huntington's disease. They report on the substance, which blocks formation of cholesterol in the brain, in the journal, ACS Chemical Biology.

21 Apr 2011

Neuralstem signs MoU with BaYi Brain Hospital for ischemic stroke program in China

Neuralstem, Inc. (NYSE Amex: CUR) announced it has signed a Memorandum of Understanding with BaYi Brain Hospital in Beijing, China.

21 Apr 2011

Gilead, MicroDose enter collaboration for inhalable small molecule antiviral fusion inhibitor MDT-637

Gilead Sciences, Inc. and MicroDose Therapeutx, Inc. today announced that the companies have entered into an exclusive worldwide license and collaboration agreement for the development and commercialization of MDT-637, MicroDose's inhalable small molecule antiviral fusion inhibitor for the treatment of respiratory syncytial virus (RSV).

20 Apr 2011

ARIAD executes three exclusive out-license agreements for ARGENT cell-signaling regulation technology

ARIAD Pharmaceuticals, Inc. today announced execution of three exclusive out-license agreements for separate aspects of its ARGENT™ cell-signaling regulation technology.

20 Apr 2011

Researchers discover new way to force cancer cells to self-destruct

Researchers at The Wistar Institute have found a new way to force cancer cells to self-destruct. Low doses of one anti-cancer drug currently in development, called Gamitrinib, sensitize tumor cells to a second drug, called TRAIL, also currently in clinical development as part of an anticancer regimen.

20 Apr 2011

Sialix announces blood test results for early detection and treatment of breast cancer

Sialix, Inc. a pioneer in glycobiology, today announced the results of a study it participated in with researchers at the University of California, San Diego School of Medicine that could have significant impact in the prediction, early detection and treatment of cancer in humans.

20 Apr 2011

Hypothalamus plays a key role in obesity and type 2 diabetes

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20 Apr 2011

Combination therapy restores skilled use of limb in rodent model

After the acute treatment window closes, the only effective treatment for stroke is physical/occupational therapy. Now scientists from Children's Hospital Boston report a two-pronged molecular therapy that leads to significant recovery of skilled motor function in a rat model of stroke.

20 Apr 2011

Researchers deploy new tool in study of tubulin tyrosine ligase in tumor growth

Many of the newest weapons in the war on cancer come in the form of personalized therapies that can target specific changes in an individual's tumor. By disrupting molecular processes in tumor cells, these drugs can keep the tumor from growing and spreading. At the forefront of this work are Binghamton University researchers, Susan Bane, and Susannah Gal, who are deploying a new tool in their study of an enzyme called tubulin tyrosine ligase, or TTL.

20 Apr 2011

Chronic inflammation due to infection may lead to cancer

A new study shows how inflammation can help cause cancer. Chronic inflammation due to infection or to conditions such as chronic inflammatory bowel disease is associated with up to 25 percent of all cancers.

20 Apr 2011

SERI selects AB SCIEX TripleTOF 5600 system to test chronic eye inflammations

AB SCIEX, a global leader in life science analytical technologies, today announced that the Singapore Eye Research Institute, an internationally known eye research center, will advance biomarker candidates it identified for chronic inflammatory eye conditions into large-scale clinical trials for validation with the AB SCIEX TripleTOF™ 5600 System.

20 Apr 2011

Antibodies to non-human sugar molecule may be useful for early detection of cancer

Researchers at the University of California, San Diego School of Medicine say antibodies to a non-human sugar molecule commonly found in people may be useful as a future biomarker for predicting cancer risk, for diagnosing cancer cases early and, in sufficient concentration, used as a treatment for suppressing tumor growth.

20 Apr 2011

OSU biophysicist leverages computer cluster to develop drug to block small protein molecule IL-6

An Ohio State biophysicist used a supercomputer to search thousands of molecular combinations for the best configuration to block a protein that can cause breast or prostate cancer.

20 Apr 2011

Plant hormone auxin acts as a signalling molecule in embryo development

During the development of organisms, a particular event repeatedly occurs: a signal appears temporarily, but the processes it triggers must be maintained - for example, when the fate of cells in the embryo is established.

20 Apr 2011

Cord blood units treated with signaling molecule show favorable safety profile in long-term animal studies

An innovative experimental treatment for boosting the effectiveness of stem-cell transplants with umbilical cord blood has a favorable safety profile in long-term animal studies, report scientists from Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, and Children's Hospital Boston.

20 Apr 2011

Molecule News and Research

Nutlin-3a molecules stimulate signal to induce cell death and senescence in brain cancer

Hanmi granted exclusive rights to Kinex KX01 Src kinase/pretubulin dual mechanism inhibitor for oncology indications

Scientists discover 'small molecule' substance that blocks cholesterol formation in the brain

Neuralstem signs MoU with BaYi Brain Hospital for ischemic stroke program in China

Gilead, MicroDose enter collaboration for inhalable small molecule antiviral fusion inhibitor MDT-637

ARIAD executes three exclusive out-license agreements for ARGENT cell-signaling regulation technology

Researchers discover new way to force cancer cells to self-destruct

Sialix announces blood test results for early detection and treatment of breast cancer

Hypothalamus plays a key role in obesity and type 2 diabetes

Combination therapy restores skilled use of limb in rodent model

Researchers deploy new tool in study of tubulin tyrosine ligase in tumor growth

Chronic inflammation due to infection may lead to cancer

SERI selects AB SCIEX TripleTOF 5600 system to test chronic eye inflammations

Antibodies to non-human sugar molecule may be useful for early detection of cancer

OSU biophysicist leverages computer cluster to develop drug to block small protein molecule IL-6

Plant hormone auxin acts as a signalling molecule in embryo development

Cord blood units treated with signaling molecule show favorable safety profile in long-term animal studies

Dogs develop cancer that is biologically similar to a human tumour

Ohio State biophysicist disrupts cellular messages through fragment-based drug design

Researchers identify TrkB antagonist with anxiolytic, antidepressant activity

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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