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Scientists characterize the lung squamous cell carcinoma genome

In the September 9, 2012 early online edition of Nature, scientists with The Cancer Genome Atlas (TCGA) report that they have characterized the lung squamous cell carcinoma genome.

10 Sep 2012

Researchers identify three genetic regions associated with primary biliary cirrhosis

Researchers have newly identified three genetic regions associated with primary biliary cirrhosis (PBC), the most common autoimmune liver disease, increasing the number of known regions associated with the disorder to 25.

10 Sep 2012

Scientists report first comprehensive genetic analysis of lung squamous cell carcinoma

A nationwide consortium of scientists has reported the first comprehensive genetic analysis of squamous cell carcinoma of the lung, a common type of lung cancer responsible for about 400,000 deaths each year.

10 Sep 2012

BCAA supplementation may treat autism and/or epilepsy

An international team of researchers, led by scientists at the University of California, San Diego and Yale University schools of medicine, have identified a form of autism with epilepsy that may potentially be treatable with a common nutritional supplement.

7 Sep 2012

GENCODE Consortium uncovers staggering array of genes in human genome

The GENCODE Consortium expects the human genome has twice as many genes than previously thought, many of which might have a role in cellular control and could be important in human disease. This remarkable discovery comes from the GENCODE Consortium, which has done a painstaking and skilled review of available data on gene activity.

7 Sep 2012

Scientists complete comprehensive map of genetic mutations linked to small cell lung cancers

Scientists have completed a comprehensive map of genetic mutations linked to an aggressive and lethal type of lung cancer.

6 Sep 2012

New approach can help researchers study genetic variations associated with disease

With the ability to sequence human genes comes an onslaught of raw material about the genetic characteristics that distinguish us, and wading through these reserves of data poses a major challenge for life scientists. Researchers at Roswell Park Cancer Institute (RPCI) and the Center for Human Genome Variation at Duke University Medical Center (DUMC) have developed an approach for analyzing data that can help researchers studying genetic factors in disease to quickly cull out relevant genetic patterns and identify variants that lead to particular disorders.

6 Sep 2012

CSHL publishes genome-wide analysis of transcripts produced within human cells

Most people understand genes to be specific segments of DNA that determine traits or diseases that are inherited. Textbooks suggest that genes are copied into RNA molecules, which are then used as templates for making protein - the highly diverse set of molecules that act as building blocks and engines of our cells. The truth, it now appears, is not so simple.

6 Sep 2012

UC Davis plans to open West Coast Metabolomics Center

With a $9.3 million startup grant from the National Institutes of Health, the University of California, Davis, has announced plans to open the West Coast Metabolomics Center, a high-tech consortium of research and service laboratories that will help scientists better understand and develop more effective treatments for complex diseases like diabetes, cancer and atherosclerosis.

6 Sep 2012

Study sheds new light on why most bone marrow transplant patients suffer acute GVHD

A team of scientists led by a bone marrow transplant researcher at Fred Hutchinson Cancer Research Center has shed new light on why most bone marrow transplant patients who receive tissue-matched cells from unrelated donors still suffer acute graft-versus-host disease (GVHD).

6 Sep 2012

LIN28 protein can bind directly to thousands of messenger RNAs

A study led by researchers at the UC San Diego Stem Cell Research program and funded by the California Institute for Regenerative Medicine (CIRM) looks at an important RNA binding protein called LIN28, which is implicated in pluripotency and reprogramming as well as in cancer and other diseases.

6 Sep 2012

Researchers discover two gene variants that raise risk of pediatric cancer neuroblastoma

Researchers have discovered two gene variants that raise the risk of the pediatric cancer neuroblastoma. Using automated technology to perform genome-wide association studies on DNA from thousands of subjects, the study broadens understanding of how gene changes may make a child susceptible to this early childhood cancer, as well as causing a tumor to progress.

5 Sep 2012

Eurofins MWG Operon acquires Illumina HiSeq 2500 and MiSeq sequencers

Eurofins MWG Operon, one of the pioneers and key providers of next generation sequencing (NGS), has added an Illumina HiSeq 2500 and an Illumina MiSeq sequencer to its fleet of NGS sequencers.

From Illumina, Inc. 5 Sep 2012

Scientists identify three new genes associated with Primary Angle Closure Glaucoma

Singapore scientists have identified three new genes associated with Primary Angle Closure Glaucoma (PACG), a leading cause of blindness in Chinese people. PACG affects 15 million people worldwide, 80% of whom live in Asia.

5 Sep 2012

Whole-genome sequencing can track origin and movement of TB pathogens

Reconstructing the spread of killer diseases such as tuberculosis (TB) from person to person using DNA sequencing quickly identifies the origin and movement of pathogens. This approach is directly informing public health strategies to control infectious disease outbreaks, says a scientist speaking at the Society for General Microbiology's Autumn Conference at the University of Warwick.

4 Sep 2012

Potential new COPD drug

A study led by researchers at Boston University School of Medicine (BUSM) has shown that a compound used in some skin creams may halt the progression of emphysema and reverse some of the damage caused by the disease. When the compound Gly-His-Lys (GHK) was applied to lung cells from patients with emphysema, normal gene activity in altered cells was restored and damaged aspects of cellular function were repaired.

1 Sep 2012

Researchers identify several genetic factors linked to C-reactive protein

African Americans have higher blood levels of a protein associated with increased heart-disease risk than European Americans, despite higher "good" HDL cholesterol and lower "bad" triglyceride levels. This contradictory observation now may be explained, in part, by a genetic variant identified in the first large-scale, genome-wide association study of this protein involving 12,000 African American and Hispanic American women.

31 Aug 2012

Weill Cornell Medical College receives three new research grants for translational blood cancer study

Weill Cornell Medical College has been awarded three new research grants from the Leukemia & Lymphoma Society totaling $1.8 million. The funds will support critically-needed translational research for blood cancers, accelerating promising discoveries from the laboratory to the patient's bedside.

31 Aug 2012

Stowers investigators define factors that regulate size of cellular fat pools

As the national waistline expands, so do pools of intra-cellular fat known as lipid droplets. Although most of us wish our lipid droplets would vanish, they represent a cellular paradox: on the one hand droplets play beneficial roles by corralling fat into non-toxic organelles. On the other, oversized lipid droplets are associated with obesity and its associated health hazards.

30 Aug 2012

Cyclin D3 protein regulates size and quantity of RBCs

The adult human circulatory system contains between 20 and 30 trillion red blood cells (RBCs), the precise size and number of which can vary from person to person. Some people may have fewer, but larger RBCs, while others may have a larger number of smaller RBCs. Although these differences in size and number may seem inconsequential, they raise an important question: Just what controls these characteristics of RBCs?

29 Aug 2012

Genome News and Research

Scientists characterize the lung squamous cell carcinoma genome

Researchers identify three genetic regions associated with primary biliary cirrhosis

Scientists report first comprehensive genetic analysis of lung squamous cell carcinoma

BCAA supplementation may treat autism and/or epilepsy

GENCODE Consortium uncovers staggering array of genes in human genome

Scientists complete comprehensive map of genetic mutations linked to small cell lung cancers

New approach can help researchers study genetic variations associated with disease

CSHL publishes genome-wide analysis of transcripts produced within human cells

UC Davis plans to open West Coast Metabolomics Center

Study sheds new light on why most bone marrow transplant patients suffer acute GVHD

LIN28 protein can bind directly to thousands of messenger RNAs

Researchers discover two gene variants that raise risk of pediatric cancer neuroblastoma

Eurofins MWG Operon acquires Illumina HiSeq 2500 and MiSeq sequencers

Scientists identify three new genes associated with Primary Angle Closure Glaucoma

Whole-genome sequencing can track origin and movement of TB pathogens

Potential new COPD drug

Researchers identify several genetic factors linked to C-reactive protein

Weill Cornell Medical College receives three new research grants for translational blood cancer study

Stowers investigators define factors that regulate size of cellular fat pools

Cyclin D3 protein regulates size and quantity of RBCs

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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