Protein C News and Research

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Study shows strong protective effect of IgG3 antibodies in SARS-CoV-2 infection

Researchers published a study on the expression and functional analyses of a neutralizing mAb with identical variable domains but different constant HCs, representing IgG1-4.

6 Oct 2021

Comparative analysis between the SARS-CoV-1 and SARS-CoV-2 mPro systems

To better understand the biophysical changes that occur due to mutations, the mechanisms of multiple SARS-CoV-2 proteins have been studied and compared with SARS-CoV-1.

6 Oct 2021

SARS-CoV-2 emerging variants display enhanced syncytia formation

Researchers compared the replication and syncytia forming potential of Alpha, Beta, and D614G strains in human cell lines and primary airway cells.

6 Oct 2021

Study shows lower SARS-CoV-2 infection rates in smokers

Coronavirus disease 2019 (COVID-19) primarily infects the lungs, later spreading through the bloodstream. The worst prognoses are mostly seen in ‘at-risk’ groups, such as the immunocompromised, elderly, or those suffering from respiratory conditions.

6 Oct 2021

University of Washington partners with USAID to better identify and prevent future pandemics

Randy CarnellLaboratory medicine scientists look through the window of equipment used in analyzing virus samples.

6 Oct 2021

Researchers solve 3D structure of supramolecular protein nanoparticle using cryo-electron microscopy

Nanoparticles and nanocages are attractive materials that may be applied in color agents, catalysts, and drug delivery. For real-world use, it is necessary to produce a large number of nanoparticles of uniform size and shape, but thus far, nanoparticle formation methods using metals have been widely researched, and the formation of nanoparticles with a certain shape and size have been realized.

6 Oct 2021

Researchers identify mechanism that can lead to deafness in rare Norrie disease

A team of Mass Eye and Ear Scientists led by Albert Edge, PhD, working with research fellow Yushi Hayashi, MD, PhD, has identified the mechanism that can lead to deafness in the rare syndrome, Norrie disease.

5 Oct 2021

Study identifies specific small RNA molecule that can reduce levels of cancer-promoting gene

In a recent study published in CANCER RESEARCH , a team led by researchers at Tokyo Medical and Dental University (TMDU) identified a specific small RNA molecule, called a microRNA (miRNA or miR), that has the potential to be used as an anti-cancer therapeutic.

5 Oct 2021

Cysteamine inhibits SARS-CoV-2 variants of concern in vitro

Researchers in the United States have shown that a compound currently used to treat cystinosis exhibits broad antiviral activity against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

5 Oct 2021

Plasmid DNA vaccines induce effective antibody responses against SARS-CoV-2 in mice

Researchers in the United States and China have developed plasmid DNA immunogens that induce effective antibody responses in mice against the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

5 Oct 2021

Hollings Cancer Center researcher awarded NCI grant to pursue early investigator studies in leukemia

MUSC Hollings Cancer Center researcher Haizhen (Jen) Wang, Ph.D., was awarded a five-year $344,000 per year grant by the National Cancer Institute to pursue her early investigator studies in leukemia.

5 Oct 2021

Cancer drug can restore memory and cognitive function in mice with Alzheimer’s symptoms

A drug commonly used to treat cancer can restore memory and cognitive function in mice that display symptoms of Alzheimer's disease, new UBC research has found.

5 Oct 2021

Plant-derived compound can be beneficial in protecting the brain against Alzheimer’s disease pathology

Fenchol, a natural compound abundant in some plants including basil, can help protect the brain against Alzheimer's disease pathology, a preclinical study led by University of South Florida Health (USF Health) researchers suggests.

5 Oct 2021

Researchers develop new method to predict biomaterial's capacity to induce tissue regeneration

Researchers from the Polymer and Advanced Materials Group at the Universitat Jaume I in Castellón have developed an in vitro method to predict the capacity of a biomaterial to induce bone and soft tissue regeneration.

5 Oct 2021

SARS-CoV-2 beta variant elicits variant specific and cross-reactive antibodies

One recent study assessed the serum of Beta variant infected patients to determine whether major non-VOC antibodies could neutralize this virus.

5 Oct 2021

$35.1 million US grant focuses on investigating sleep disorder linked to neurodegeneration

People with rapid eye movement (REM) sleep behavior disorder act out their dreams. While sleeping safely in bed, for example, they might throw up their arms to catch an imaginary ball, or try to run from an illusory assailant.

5 Oct 2021

The role of ZBP1 in promoting SARS-CoV-2-induced cytokine expression

A new study reported that the ZBP1-induced inflammatory signaling pathway is dependent on ubiquitination and RIPK3’s scaffolding ability, independent of cell death.

5 Oct 2021

New mathematical tool used to study the genetic interactions associated with cancer

Biologists at Cold Spring Harbor Laboratory are using a mathematical approach developed in CSHL Assistant Professor David McCandlish's lab to find solutions to a diverse set of biological problems.

5 Oct 2021

Humoral responses to SARS-CoV-2 are detectable through saliva, scientists find

Your saliva may be able to tell you if you’ve developed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies, suggests a new medRxiv* preprint study. In immunocompromised groups, salivary Immunoglobulin G (IgG) antibody levels were associated with IgG titers in blood serum 3 to 4 weeks after mRNA vaccination.

5 Oct 2021

Inflammatory molecules "trapped" inside micro clots may be the cause of Long COVID symptoms

New research indicates that an overload of various inflammatory molecules, literally "trapped" inside insoluble microscopic blood clots (micro clots), might be the cause of some of the lingering symptoms experienced by individuals with Long COVID.

5 Oct 2021

Protein C News and Research

Study shows strong protective effect of IgG3 antibodies in SARS-CoV-2 infection

Comparative analysis between the SARS-CoV-1 and SARS-CoV-2 mPro systems

SARS-CoV-2 emerging variants display enhanced syncytia formation

Study shows lower SARS-CoV-2 infection rates in smokers

University of Washington partners with USAID to better identify and prevent future pandemics

Researchers solve 3D structure of supramolecular protein nanoparticle using cryo-electron microscopy

Researchers identify mechanism that can lead to deafness in rare Norrie disease

Study identifies specific small RNA molecule that can reduce levels of cancer-promoting gene

Cysteamine inhibits SARS-CoV-2 variants of concern in vitro

Plasmid DNA vaccines induce effective antibody responses against SARS-CoV-2 in mice

Hollings Cancer Center researcher awarded NCI grant to pursue early investigator studies in leukemia

Cancer drug can restore memory and cognitive function in mice with Alzheimer’s symptoms

Plant-derived compound can be beneficial in protecting the brain against Alzheimer’s disease pathology

Researchers develop new method to predict biomaterial's capacity to induce tissue regeneration

SARS-CoV-2 beta variant elicits variant specific and cross-reactive antibodies

$35.1 million US grant focuses on investigating sleep disorder linked to neurodegeneration

The role of ZBP1 in promoting SARS-CoV-2-induced cytokine expression

New mathematical tool used to study the genetic interactions associated with cancer

Humoral responses to SARS-CoV-2 are detectable through saliva, scientists find

Inflammatory molecules "trapped" inside micro clots may be the cause of Long COVID symptoms

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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