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The new FlowCam® LO improves particle characterization in drug development

Yokogawa Fluid Imaging Technologies announces the release of the FlowCam® LO, the first and only light obscuration instrument with imaging capabilities.

From Yokogawa Fluid Imaging Technologies, Inc. 29 Sep 2021

Methylation of TDP-43 DNA linked to age-dependent motor cortex involvement in ALS

Amyotrophic lateral sclerosis (ALS) is an intractable neurological disease. Aging is a risk factor for the accumulation of TDP-43 (transduction responsive region DNA-binding protein of 43kDa) in the motor cortex. TDP-43 is a protein that tends to accumulate in increasing amounts, and the amount is strictly controlled by the splicing of TDP-43. Through cell experiments and analysis of human brain tissue, researchers at Brain Research Institute, Niigata University, led by Akihiro Sugai, M.D., Ph.D., have found that methylation of TDP-43 DNA is involved in the background of motor cortex involvement with aging in ALS

29 Sep 2021

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

Oncotarget published "Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells" which reported that there was an increase in IL-8 by oxaliplatin and increase in ferritin by cisplatin which may contribute to cancer cell survival.

29 Sep 2021

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Oncotarget published "Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells" which reported that to ascertain phenotypical differences between these two distinct culture conditions, these authors carried out a comparative proteomic analysis of a membrane fraction obtained from 3D- and 2D-cultured NSCLC model cell line NCI-H23.

29 Sep 2021

Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Oncotarget published "Multipeptide stimulated PBMCs generate TEM/TCM for adoptive cell therapy in multiple myeloma" which reported that Multiple Myeloma patients suffer disease relapse due to the development of therapeutic resistance. Increasing evidence suggests that immunotherapeutic strategies can provide durable responses.

29 Sep 2021

Research finds increases in 'pandemic brain' after COVID-19 lockdowns

Chances are, the COVID-19 pandemic has affected your health — even if you have never been infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). According to new research from Harvard Medical School, the stress of isolation from lockdown and stay-at-home measures is making people sick.

29 Sep 2021

Could vitamin A help to regain your smell loss after COVID-19?

Could vitamin A help to regain your smell after COVID-19? New research is trying to find out, and we spoke exclusively to Professor Carl Philpott to find out more.

29 Sep 2021

How effective are COVID-19 vaccines against SARS-CoV-2 variants of concern?

The authors from this paper performed a systematic review and meta-analysis evaluating vaccine effectiveness from RCTs and observational studies.

29 Sep 2021

Human coronavirus replicates in bats without using the spike protein

Researchers in Singapore have conducted a study showing active replication of a human coronavirus in bats that occurred without the viral spike protein binding to host cell receptors.

28 Sep 2021

Researchers develop new mouse model for studying non-Demented with Alzheimer’s disease

Alzheimer's is a neurodegenerative disease that features the accumulation of the beta-amyloid peptide and Tau protein in the brain, which are associated with deficits in the neuronal connections and with dementia.

28 Sep 2021

Southeast Asia - A hotspot of many viruses with potential to cause pandemics

A new study reveals that scientists have found three viruses in bats in Laos that exhibit similar characteristic features as SARS-CoV-2.

28 Sep 2021

Quantification of antibody titers against SARS-CoV-2 variants elicited by BNT162b2 vaccine

A new study discusses the development of dedicated reagents against the SARS-CoV-2 spike protein through the use of an automated CLEIA system.

28 Sep 2021

New findings highlight the need to expand the toolbox to fight against COVID-19

When Kamlendra Singh flew back to Missouri from India in April, he developed a cough and fever on the plane, despite being vaccinated for COVID-19 and testing negative for the virus right before departure.

28 Sep 2021

Supercoiling and looping can transmit mechanical stress along the DNA backbone, research shows

When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are known to influence every aspect of DNA activity, but how this happens has not been clear.

28 Sep 2021

Primary sclerosing cholangitis: Therapy with synthetic bile acid acts directly on the immune system

Primary Sclerosing Cholangitis (PSC) is a rare, chronic inflammatory disease of the bile ducts and is difficult to treat. Studies conducted by the Division of Gastroenterology and Hepatology at MedUni Wien under the guidance of Michael Trauner (Department of Internal Medicine III) were able to show positive effects from the administration of synthetically produced bile acids and bile acid receptor agonists.

28 Sep 2021

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

New findings identify CASP4/11 as detrimental to inflammation and coagulopathy associated with SARS-CoV-2 infection.

28 Sep 2021

Super-resolution imaging and size analysis of SARS-CoV-2 virus particles

Researchers from the University of Oxford and the University of Warwick have collaborated to develop a method to better understand and evaluate these pleiomorphisms.

28 Sep 2021

Researchers create an integrated pipeline for performing genetic screening studies

Today's genetic engineers have a plethora of resources at their disposal: an ever-increasing number of massive datasets available online, highly precise gene editing tools like CRISPR, and cheap gene sequencing methods. But the proliferation of new technologies has not come with a clear roadmap to help researchers figure out which genes to target, which tools to use, and how to interpret their results. So, a team of scientists and engineers at Harvard's Wyss Institute for Biologically Inspired Engineering, Harvard Medical School (HMS), and the MIT Media Lab decided to make one.

28 Sep 2021

Evidence of persisting autoreactivity in post-acute sequelae of SARS-CoV-2 infection?

It has been demonstrated in recent studies that there is a significant breadth of emerging autoreactivity associated with severe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. More specifically, researchers from Emory University have identified a relaxation of peripheral tolerance within early antibody secretion cells that arise in individuals infected with SARS-CoV-2, as important drivers of those responses.

28 Sep 2021

Novel polyclonal antibody therapy meets the criteria for graduation to phase 3 in ACTIV-2 trial

The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, which recently expanded its focus to include evaluating outpatient treatment for COVID-19, today announced that SAB-185, a novel polyclonal antibody therapy, has demonstrated safety and efficacy in phase 2 that meet the criteria for graduation to phase 3 in the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial (ACTG A5401).

28 Sep 2021

Protein C News and Research

The new FlowCam® LO improves particle characterization in drug development

Methylation of TDP-43 DNA linked to age-dependent motor cortex involvement in ALS

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Research finds increases in 'pandemic brain' after COVID-19 lockdowns

Could vitamin A help to regain your smell loss after COVID-19?

How effective are COVID-19 vaccines against SARS-CoV-2 variants of concern?

Human coronavirus replicates in bats without using the spike protein

Researchers develop new mouse model for studying non-Demented with Alzheimer’s disease

Southeast Asia - A hotspot of many viruses with potential to cause pandemics

Quantification of antibody titers against SARS-CoV-2 variants elicited by BNT162b2 vaccine

New findings highlight the need to expand the toolbox to fight against COVID-19

Supercoiling and looping can transmit mechanical stress along the DNA backbone, research shows

Primary sclerosing cholangitis: Therapy with synthetic bile acid acts directly on the immune system

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

Super-resolution imaging and size analysis of SARS-CoV-2 virus particles

Researchers create an integrated pipeline for performing genetic screening studies

Evidence of persisting autoreactivity in post-acute sequelae of SARS-CoV-2 infection?

Novel polyclonal antibody therapy meets the criteria for graduation to phase 3 in ACTIV-2 trial

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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