Animal Model News and Research

RSS

People battling substance use disorders may benefit from meth-relapse prevention compound

New research raises the possibility that a wider group of people battling substance use disorders may benefit from a Scripps Research-developed relapse-prevention compound than previously thought.

17 Sep 2018

New dopamine sensors could improve our understanding of Parkinson’s Disease

Researchers have developed a sensor that can measure dopamine in the brain for more than a year. The tech could help us understand Parkinson's and depression.

12 Sep 2018

Differences in mitochondrial DNA determine severity of heart disease caused by nDNA mutation

Differences in the DNA within the mitochondria, the energy-producing structures within cells, can determine the severity and progression of heart disease caused by a nuclear DNA mutation.

12 Sep 2018

Study: Health and longevity improves with increased fasting time

Increasing time between meals made male mice healthier overall and live longer compared to mice who ate more frequently, according to a new study published in the Sept. 6, 2018 issue of Cell Metabolism.

7 Sep 2018

Marmosets can mimic both motor and non-motor symptoms of Parkinson's disease

Small, New World monkeys called marmosets can mimic the sleep disturbances, changes in circadian rhythm, and cognitive impairment people with Parkinson's disease develop, according to a new study by scientists at Texas Biomedical Research Institute.

6 Sep 2018

Research shows new way to target drug delivery for brain tumors

A person's brainstem controls some of the body's most important functions, including heart beat, respiration, blood pressure and swallowing. Tumor growth in this part of the brain is therefore twice as devastating.

5 Sep 2018

Scientists explore DNA replication errors that can lead to cancer

Scientists at Hollings Cancer Center at the Medical University of South Carolina have found that some cells can divide without a molecule that was previously thought necessary.

30 Aug 2018

Researchers take major step forward in finding safe and non-addictive pain killer

With the support of the National Institute on Drug Abuse, scientists at Wake Forest School of Medicine have been working to find a safe, non-addictive pain killer to help fight the current opioid crisis in this country.

30 Aug 2018

New study reports key steps towards development of acne vaccine

A new study published in the Journal of Investigative Dermatology reports important steps that have been taken towards the development of an acne vaccine.

29 Aug 2018

Restricting consumption of high-sucrose diet to active part of day avoids adverse effects in rats

A sedentary lifestyle combined with a diet dominated by processed foods has widely resulted in a range of conditions including diabetes, obesity, and high blood pressure, which are known collectively as metabolic syndrome.

27 Aug 2018

Individual hypertensive responses to antibiotics may vary depending on genetic makeup and gut bacteria

Individual variations in genetic makeup and gut bacteria may explain the different effects of antibiotics on blood pressure, a new rat study suggests. The findings are published ahead of print in Physiological Genomics.

23 Aug 2018

Scientists publish study results of AAV therapy product for treatment of RHO-adRP

Ophthotech Corporation announced today that scientists at the University of Pennsylvania and University of Florida published proof-of-concept study results on an adeno-associated virus gene therapy product candidate for the treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa licensed by Ophthotech.

22 Aug 2018

Federal grant extends and expands research into acute kidney failure

The National Institute of Diabetes and Digestive and Kidney Diseases has renewed a grant shared by the University of Alabama at Birmingham School of Medicine and the University of California at San Diego School of Medicine that will extend and expand research into acute kidney failure, or acute kidney injury, which affects about 1.2 million hospitalized patients per year and kills 70 to 80 percent of patients in intensive care units who develop the disease.

22 Aug 2018

Gene therapy with telomerase does not increase cancer risk, study shows

Negative results and findings in science are perhaps less newsworthy, but they are no less important. Particularly when, as in this case, they demonstrate that a possible new therapeutic pathway against idiopathic pulmonary fibrosis and other diseases associated to short telomeres is in fact safe.

21 Aug 2018

Researchers publish new paper on developing vaccine candidates for Helminthic parasites

Helminthic parasites, like hookworm and liver flukes (schistosomiasis), affect an estimated 1 billion people worldwide. Infection from hookworm and schistosomiasis result in a combined loss of as much as 92 million disability-adjusted life years annually.

17 Aug 2018

Penn researchers develop first mouse model of idiopathic pulmonary fibrosis

The biggest hurdle to finding effective therapies for idiopathic pulmonary fibrosis (IPF) – a life-threatening condition in which the lungs become scarred and breathing is increasingly difficult – has been the inability to fully model the disease in animals, limiting the ability to observe and understand the disease.

16 Aug 2018

New polyclonal immunotherapy successfully neutralizes Ebola virus

SAB Biotherapeutics, Inc., a clinical-stage biopharmaceutical company, today announced that its anti-Ebola immunotherapy (SAB-139) provided "100% protection against a lethal dose of the Ebola virus" in a recent animal study published in The Journal of Infectious Diseases.

15 Aug 2018

Study shows efficacy, safety of AAV5-based gene therapy to treat sheep model of achromatopsia

A study of a large animal model of achromatopsia caused by a mutation in the CNGA3 gene that was treated with a single injection of CNGA3 gene therapy delivered using an AAV5 vector revealed findings reported long-term follow-up findings that show promise for the efficacy and safety of this therapeutic approach.

15 Aug 2018

Neural stem cells are the key to tail regeneration

Cut off a salamander's tail and, in a few weeks, a near-perfect replacement grows. Do the same to a lizard and a new tail will regrow, but it won't be the same as the original. By comparing tail regeneration between the two animals, researchers at the University of Pittsburgh School of Medicine found that stem cells in the spinal cord are the ultimate limiting factor.

14 Aug 2018

Researchers develop revolutionary zebrafish model to gain more insight into bone diseases

Although much scientific research has been done into the development of the skeleton, the underlying mechanisms that drive the formation and maintenance of our bones are still not very well understood, and research into the development of our bone remains of enormous importance.

13 Aug 2018