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No single global optimal solution for deimmunization of a given biotherapeutic agent

By establishing protein design algorithms that simultaneously optimize drug candidates for both decreased immunogenic epitope content and high level stability and activity, Dartmouth's Norris Cotton Cancer Center investigator Karl Griswold, PhD, and his collaborator Chris Bailey-Kellogg, PhD, have established a novel testing platform.

31 Jan 2015

UNC researchers discover how two genes interact to trigger worst form of ovarian cancer

In the battle against ovarian cancer, UNC School of Medicine researchers have created the first mouse model of the worst form of the disease and found a potential route to better treatments and much-needed diagnostic screens.

27 Jan 2015

PKC enzymes categorized as cancer promoters are actually tumor suppressors

Upending decades-old dogma, a team of scientists at the University of California, San Diego School of Medicine say enzymes long categorized as promoting cancer are, in fact, tumor suppressors and that current clinical efforts to develop inhibitor-based drugs should instead focus on restoring the enzymes' activities.

23 Jan 2015

Regular outdoor walking in groups boosts health, reduces life-threatening conditions

Risk of stroke, coronary heart disease, depression and other life-threatening conditions can be reduced through regular outdoor walking in groups, according to research from the University of East Anglia.

19 Jan 2015

Modelling the biological mesoscale: an interview with Professor Art Olson

The biological mesoscale range includes biological structures that range from 10 to 100 nanometers (billionths of a meter). Structures in this size range include viruses, cellular organelles, large molecular complexes, and any other internal cellular environments within that range.

18 Jan 2015

YODA Project announces availability of clinical trial data for medical devices

The Yale University Open Data Access (YODA) Project is announcing the first-ever broad availability of clinical trial data for medical devices and diagnostics by a company. This historic expansion of data sharing is made possible through collaboration with Johnson & Johnson.

15 Jan 2015

Reducing fears key to success of CBT or GET in people with chronic fatigue syndrome

Reducing fears that exercise or activity will make symptoms worse is one of the most important factors determining the success of cognitive behaviour therapy (CBT) or graded exercise therapy (GET) in reducing fatigue and improving physical function in people with chronic fatigue syndrome (CFS), according to new analysis of data from the PACE trial, reported in The Lancet Psychiatry journal.

14 Jan 2015

MGB Biopharma provides update on business performance for 2014

MGB Biopharma, a biopharmaceutical company developing a truly novel class of anti-infectives, provides an update on its business performance for 2014. MGB Biopharma is developing a pipeline of novel antimicrobials that puts it at the forefront of addressing the major global problem of antimicrobial resistance.

12 Jan 2015

New insight into molecular mechanism of ancient evolutionary enzyme

A team led by structural biologists at The Scripps Research Institute has taken a big step toward understanding the intricate molecular mechanism of a metabolic enzyme produced in most forms of life on Earth.

12 Jan 2015

FDA approves Novo Nordisk’s weight loss injection, Saxenda

Novo Nordisk today announced that the Food and Drug Administration (FDA) has approved the new drug application (NDA) for Saxenda® (liraglutide [rDNA origin] injection), the first once-daily glucagon-like peptide-1 (GLP-1) receptor agonist for chronic weight management.

25 Dec 2014

TSRI scientists discover new method for joining complex organic molecules

Chemists at The Scripps Research Institute have invented a powerful method for joining complex organic molecules that is extraordinarily robust and can be used to make pharmaceuticals, fabrics, dyes, plastics and other materials previously inaccessible to chemists.

18 Dec 2014

Two UH researchers named fellows of National Academy of Inventors

Two University of Houston faculty members have been named fellows of the National Academy of Inventors for their contributions to scientific and technological innovation.

17 Dec 2014

Stuttgart scientists reveal current state of research on catalytic micro- and nanomotors

At least since the movie “The Fantastic Voyage” in 1966, in which a submarine is shrunk down and injected into the blood stream of a human, people have been toying with the idea of sending tiny “micromachines” and “nanorobots” into our organs or individual cells to carry out delicate “repairs”.

17 Dec 2014

Scientists receive NSF funding to develop, commercialize artificial cell manufacturing for education

National Science Foundation funding to develop and commercialize artificially-manufactured cells and cell platforms for educational, research and industry application has been awarded to a team of scientists led by Dr. Mark DeCoster, the James E. Wyche III Professor in Biomedical Engineering at Louisiana Tech University.

15 Dec 2014

CWRU researchers find mechanism that enables LRAT enzyme to store vitamin A

Researchers at Case Western Reserve University School of Medicine have uncovered the mechanism that enables the enzyme Lecithin: retinol acyltransferase (LRAT) to store vitamin A — a process that is indispensable for vision.

12 Dec 2014

Enzymatic activity essential for vision may provide target for drug transport

10 Dec 2014

Experts launch new interdisciplinary scientific collaboration to improve health in urban areas

Aiming to empower planners and policy-makers to achieve better health for billions of people living in fast-growing urban areas, world health, environmental, behavioural and social science experts today launched a major new interdisciplinary scientific collaboration.

9 Dec 2014

UTHealth receives $7.3 million grant to research on health information technology

The University of Texas Health Science Center at Houston School of Biomedical Informatics has been awarded grants totaling $7.3 million to enhance health care and biomedical discovery through the use of health information technology.

8 Dec 2014

Researchers figure out how to reverse characteristics of polyurea materials

Researchers at the University of Illinois at Urbana-Champaign have figured out how to reverse the characteristics of a key bonding material--polyurea--providing an inexpensive alternative for a broad number of applications, such as drug delivery, tissue engineering, and packaging.

5 Dec 2014

Research to Prevent Blindness, IRRF partner to advance knowledge about AMD

Research to Prevent Blindness, the leading eye research foundation, is partnering with the International Retinal Research Foundation to advance knowledge about age-related macular degeneration (AMD) through novel stem cell research.