Interleukin 2 News and Research

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SARS-CoV-2 can cause persistent dendritic cell deficiencies

In a new study, the persistent influence of SARS-CoV-2 on dendritic cell deficiency seven months post-infection is asserted, and the mechanism of action investigated.

24 Mar 2021

Dandelion extract inhibits SARS-CoV-2 in vitro

An exciting new study describes a specific inhibitor of the SARS-CoV-2 found in an extract of the common dandelion that could provide a new and fruitful avenue of drug research.

23 Mar 2021

Biological “feed-forward” loop contributes to progression of osteoarthritis

An unfortunate biological "feed-forward" loop drives cartilage cells in an arthritic joint to actually contribute to progression of the disease, say researchers at Duke University and Washington University in Saint Louis.

23 Mar 2021

Biological feed-forward loop drives cartilage cells in an arthritic joint to contribute to progression of the disease

23 Mar 2021

Male fertility and androgen production may be impacted by COVID-19

An interesting new study has appeared online in the journal Hormones that discusses the effects of COVID-19 on the male and female gonads.

22 Mar 2021

Circular RNA vaccine shows neutralizing activity against B.1.351 variant

New preclinical research led by Wensheng Wei from Peking University in China has proposed the development of a circular RNA vaccine. Their findings showed the circular RNA vaccine creates neutralizing antibodies and strong T-cell responses against the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

21 Mar 2021

Do Artemisia annua L. compounds have SARS-CoV-2 antiviral potential?

Caused by SARS-CoV-2, the ongoing COVID-19 pandemic has led to over 121.2 million cases and over 2.6 million deaths worldwide. An interesting new study examines the potential antiviral activity of compounds present in the plant Artemisia annua L.

18 Mar 2021

Which biomarkers can help predict severe COVID-19?

The ability to detect potentially fatal illness early on in the course of the disease would enable a swift prioritization of these high-risk individuals for treatment. A new preprint on the medRxiv* server presents an array of biomarkers that may help achieve this laudable goal.

15 Mar 2021

SARS-CoV-2 can infect blood monocytes and trigger inflammation, finds study

Researchers found about 10% of blood monocytes in coronavirus disease 2019 (COVID-19) patients are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These monocytes then die, leading to the release of cytokines – a feature associated with severe and critical COVID-19.

11 Mar 2021

Translational research results in promising combination therapeutic candidate for type 1 diabetes

Translational research led by scientists at La Jolla Institute for Immunology (LJI) has resulted in a promising combination therapeutic candidate for adults with recent-onset type 1 diabetes.

9 Mar 2021

Ultraviolet light therapy reduces viral load in critically ill COVID-19 patients

Scientists from the United States has recently evaluated the safety and efficacy profiles of ultraviolet-A (UVA) light applied via an endotracheal tube to critically ill COVID-19 patients.

9 Mar 2021

A SARS-CoV-2 spike protein adjuvant vaccine candidate produces durable rapid protection in vivo

A recent study reports the safety and high efficacy of an adjuvanted vaccine candidate against SARS-CoV-2 and the complications of COVID-19.

5 Mar 2021

Administering zinc supplements to Covid-19 patients may help reduce mortality and recovery time

Administering zinc supplements to Covid-19 patients with low levels of this element may be a strategy to reduce mortality and recovery time.

4 Mar 2021

Study: Bitter plant compound reduces inflammatory markers

Resveratrol is a plant compound found primarily in red grapes and Japanese knotweed. Its synthetic variant has been approved as a food ingredient in the EU since 2016.

3 Mar 2021

How SARS-CoV-2 proteins affect vascular functionality

The study, published on the pre-print server medRxiv, can pinpoint and isolate how each of the SARS-CoV-2 proteins independently affects the endothelial response and directly gauge endothelial functionality.

3 Mar 2021

Yale researchers identify multiple genes involved in suppression of axon regeneration

When central nervous system cells in the brain and spine are damaged by disease or injury, they fail to regenerate, limiting the body's ability to recover.

2 Mar 2021

Study shows asthma mediator IL-13 prevents SARS-CoV-2 infection

In a paper published on the bioRxiv preprint server, researchers reported the results on whether IL-13 expression in asthma patients reduces their susceptibility to SARS-CoV-2 infection.

1 Mar 2021

Study: Repurposed arthritis drug did not improve outcomes of patients with severe COVID-19 pneumonia

In a study published online February 25, 2021 in The New England Journal of Medicine, a repurposed drug used to treat arthritis did not significantly improve the outcomes of patients with severe COVID-19 pneumonia.

1 Mar 2021

SARS-CoV-2 modulates host cell central carbon metabolism for reproduction

A team of scientists from Sweden and India has recently characterized the host cell metabolic alterations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Their findings reveal that SARS-CoV-2 modulates the host cell's central carbon metabolism to facilitate replication and infection propagation.

28 Feb 2021

Corticosteroid receptor inhibitor shows anti-SARS-CoV-2 activity in vivo

A team of researchers examined PT150, which is an allosteric modulator of androgen and glucocorticoid receptors, to assess whether it had any antiviral activity or immunomodulatory activity to decrease the hyperinflammatory response of SARS-CoV-2 infection.

24 Feb 2021

Interleukin 2 News and Research

SARS-CoV-2 can cause persistent dendritic cell deficiencies

Dandelion extract inhibits SARS-CoV-2 in vitro

Biological “feed-forward” loop contributes to progression of osteoarthritis

Biological feed-forward loop drives cartilage cells in an arthritic joint to contribute to progression of the disease

Male fertility and androgen production may be impacted by COVID-19

Circular RNA vaccine shows neutralizing activity against B.1.351 variant

Do Artemisia annua L. compounds have SARS-CoV-2 antiviral potential?

Which biomarkers can help predict severe COVID-19?

SARS-CoV-2 can infect blood monocytes and trigger inflammation, finds study

Translational research results in promising combination therapeutic candidate for type 1 diabetes

Ultraviolet light therapy reduces viral load in critically ill COVID-19 patients

A SARS-CoV-2 spike protein adjuvant vaccine candidate produces durable rapid protection in vivo

Administering zinc supplements to Covid-19 patients may help reduce mortality and recovery time

Study: Bitter plant compound reduces inflammatory markers

How SARS-CoV-2 proteins affect vascular functionality

Yale researchers identify multiple genes involved in suppression of axon regeneration

Study shows asthma mediator IL-13 prevents SARS-CoV-2 infection

Study: Repurposed arthritis drug did not improve outcomes of patients with severe COVID-19 pneumonia

SARS-CoV-2 modulates host cell central carbon metabolism for reproduction

Corticosteroid receptor inhibitor shows anti-SARS-CoV-2 activity in vivo

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