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CWRU professor wins $3.9 million NIH grant to identify countermeasures against chemical hazards

Kurt Lu, MD, assistant professor of dermatology at Case Western Reserve University School of Medicine, has received a five year, $3.9 million grant from the National Institutes of Health to expand countermeasures against chemical threats, including mustard gas and mustard-related compounds.

7 Sep 2017

Research shows new method for rapidly producing antimalarial drug at industrial scale

Compared to smallpox or typhoid, malaria is proving one of the most challenging human diseases to eradicate - and so remains a real and constant danger to nearly half the world's population.

7 Sep 2017

Differentiating sepsis and systemic inflammatory response syndrome using biomarkers

Firstly, it is necessary to make a distinction between systemic inflammation and Systemic Inflammatory Response Syndrome (SIRS). SIRS consists of changes in clinical signs including an abnormal body temperature, increased heart rate, increased respiratory rate, an abnormal white cell count (either decreased or elevated), or an increase in band neutrophils.

7 Sep 2017

Early signs of cardiovascular risk found in children exposed to 9/11 dust

Sixteen years after the collapse of the World Trade Center towers sent a "cloud" of toxic debris across Lower Manhattan, children living nearby who likely breathed in the ash and fumes are showing early signs of risk for future heart disease.

7 Sep 2017

Researchers find signaling pathway in cells that plays key role in development of fatty liver disease

Morbid obesity affects the liver: Almost one-third of all adults suffer from chronic fatty liver disease, which can lead to infections and even trigger cancer. Researchers at the University Children's Hospital Zurich and the University of Zurich have now found a signaling pathway in cells that play an important role in the development of fatty liver disease.

7 Sep 2017

Fatty acid-derived bioactive molecule helps improve heart function after heart attack in mice

Heart attacks provoke an acute immune response. Leukocytes rush to the heart muscle to remove dead cells and begin building scar tissue. This is followed by a second immune response, the resolving phase that allows healing.

7 Sep 2017

Breakthrough study could lead to diagnostic tools and better treatments for chronic bronchitis

When a patient arrives at a doctor's office with a persistent cough and the sensation of gunk building up in the lungs, the doctor's thought process is essentially the same as it would have been decades ago. There has been no understanding of the affected biological pathways causing the gunk buildup in the lung, nor has there been a diagnostic test for chronic bronchitis.

7 Sep 2017

Discovery of sugar 'warehouse' provides new metabolic target to regulate immune activity

A surprising discovery that immune cells possess an internal warehouse of glycogen used to activate immune responses could help to increase immune activity in vaccines or suppress immune reactions in autoimmune disease or hyper-inflammatory conditions.

6 Sep 2017

Novel, ultra-rare damaging genetic variants may contribute to eating disorders

By combining whole exome sequencing, machine learning, and network analysis, researchers have identified new, ultra-rare gene mutations within specific biological pathways that may contribute to eating disorders.

5 Sep 2017

Biodegradable nanoparticle injected after spinal cord injury limits damage

After a spinal cord injury, a significant amount of secondary nerve damage is caused by inflammation and internal scarring that inhibits the ability of the nervous system to repair itself.

5 Sep 2017

Researchers identify gene linked to brain damage in pre-term babies

A gene has been identified by researchers at King's College London that is thought to be associated with the types of brain damage that can be caused by pre-term birth.

5 Sep 2017

Study reveals etosis phenomenon in human blood monocytes

A recent study published online in the Journal of Leukocyte Biology found the first clear demonstration of etosis in human blood monocytes, a type of immune cell.

1 Sep 2017

New study offers insights on mechanisms behind development of kidney damage due to obesity

A new study provides insights on the mechanisms behind the development of kidney damage due to obesity. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology, point to a potential target for protecting the kidney health of individuals with obesity.

1 Sep 2017

Fat may influence cancer development in diverse ways

Adipose tissue, or fat, may influence the development of cancer in diverse ways, depending on the type of fat and the location in the body.

1 Sep 2017

Inflammation originating from abdominal fat precedes development of sleep apnea, findings suggest

Inflammation is traditionally thought of as a symptom of sleep apnea, but it might actually precede the disorder, potentially opening the door for new ways to treat and predict sleep apnea, according to researchers.

1 Sep 2017

Link found between fetal genes and risk of preeclampsia in mother

For the first time, a relationship has been found between fetal genes and the risk of preeclampsia in the mother.

31 Aug 2017

New trial examines whether compound given before and after bypass surgery mitigates cognitive deficits

University of Arizona researchers are collaborating on a Phase 2 trial to determine whether a particular peptide administered before and after coronary bypass surgery mitigates or even reverses cognitive deficits thought to be connected to the procedure.

31 Aug 2017

New research shows estrogen synthesis may fight off infection-induced neuroinflammation

The chemical best-known as a female reproductive hormone--estrogen--could help fight off neurodegenerative conditions and diseases in the future.

31 Aug 2017

Gout patient hospitalizations: what’s causing the increase?

We looked at all hospitalizations in patients with gout. The concern is that gout is often considered as a disease of just the joints, specifically of the big toe. Yet, there have been quite a lot of studies that have talked about the many other comorbidities that occur because of hyperuricemia and gout. The idea is that it's not just the crystal deposits in the joint, but other consequences that are happening because of this disease in the rest of the body.

31 Aug 2017

Soul purpose: Seniors with strong reasons to live often live stronger

Building and maintaining a career became a primary driver in her life after Newman raised two daughters and went back to work at age 48. As a therapist, "I really loved helping people make changes in their lives that put them in a different, better position," she said.

31 Aug 2017

Inflammation News and Research

CWRU professor wins $3.9 million NIH grant to identify countermeasures against chemical hazards

Research shows new method for rapidly producing antimalarial drug at industrial scale

Differentiating sepsis and systemic inflammatory response syndrome using biomarkers

Early signs of cardiovascular risk found in children exposed to 9/11 dust

Researchers find signaling pathway in cells that plays key role in development of fatty liver disease

Fatty acid-derived bioactive molecule helps improve heart function after heart attack in mice

Breakthrough study could lead to diagnostic tools and better treatments for chronic bronchitis

Discovery of sugar 'warehouse' provides new metabolic target to regulate immune activity

Novel, ultra-rare damaging genetic variants may contribute to eating disorders

Biodegradable nanoparticle injected after spinal cord injury limits damage

Researchers identify gene linked to brain damage in pre-term babies

Study reveals etosis phenomenon in human blood monocytes

New study offers insights on mechanisms behind development of kidney damage due to obesity

Fat may influence cancer development in diverse ways

Inflammation originating from abdominal fat precedes development of sleep apnea, findings suggest

Link found between fetal genes and risk of preeclampsia in mother

New trial examines whether compound given before and after bypass surgery mitigates cognitive deficits

New research shows estrogen synthesis may fight off infection-induced neuroinflammation

Gout patient hospitalizations: what’s causing the increase?

Soul purpose: Seniors with strong reasons to live often live stronger

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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