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Major international research center may drive the development of future stem cell-based treatments

A grant from the Novo Nordisk Foundation of up to 300 million euro now enables the establishment of a major international research center focused on stem cell medicine.

17 Dec 2021

A Day in the Life of A Clinical Geneticist

In this interview, we spoke to Dr. Julian Barwell, a clinical geneticist, about his day-to-day roles and responsibilities as well as his career highlights.

17 Dec 2021

Recycling tubular endosomes are associated with effective delivery of mRNA-based therapeutics, study finds

A recent study recently demonstrates the endosomal transport of nanoparticle-based formulations for the effective delivery of mRNA-based therapeutics.

14 Dec 2021

"Supermere" discovery may offer clues to earlier diagnoses and treatment of several diseases

Researchers at Vanderbilt University Medical Center have discovered a nanoparticle released from cells, called a "supermere," which contains enzymes, proteins and RNA associated with multiple cancers, cardiovascular disease, Alzheimer's disease and even COVID-19.

14 Dec 2021

Novel breathalyzer relies on viral RNA detection to diagnose SARS-CoV-2

In a new study in The Journal of Molecular Diagnostics, published by Elsevier, investigators report on the design and testing of a breathalyzer, known as the Bubbler, that relies on viral RNA detection to diagnose SARS-CoV-2.

13 Dec 2021

Researchers recapitulate the human form of arrhythmogenic cardiomyopathy in zebrafish model

The research groups of Jeroen Bakkers (Hubrecht Institute/UMC Utrecht) and Toon van Veen (UMC Utrecht) bring forward the first patient-specific model for the heart disease arrhythmogenic cardiomyopathy (ACM).

9 Dec 2021

Keto diet does not appear to work well for women

Scientists from UC Riverside are studying how the popular keto and intermittent fasting diets work on a molecular level, and whether both sexes benefit from them equally.

8 Dec 2021

Metrion Biosciences expands ion channel drug discovery service capabilities and in-house expertise

Metrion today announced it has expanded its capabilities and expertise through the addition of automated low volume liquid handling capability.

From Metrion Biosciences Limited 7 Dec 2021

Research offers a phylogenetic and ontogenetic overview of the primitive streak

In their publication in Science, Professor Guojun Sheng (Kumamoto University, Japan), Professor Alfonso Martinez Arias (Universidad Pompeu Fabra, Spain) and Professor Ann Sutherland (University of Virginia Health System, USA) offer a phylogenetic and ontogenetic overview of the primitive streak and its role in mediating amniote (vertebrate animals that develop on land) gastrulation, and discuss the implications of embryonic stem cell-based models of early mammalian embryogenesis on the function of this structure.

4 Dec 2021

New genetic technology for gene expression analysis of cancer cells

In this interview, News-Medical speaks to Dr. Rong Lu about her recent research into the development of a new genetic technology for gene expression analysis of cancer cells.

3 Dec 2021

Penn researchers illuminate key molecular details of T-cell exhaustion process

Specially engineered immune cells called CAR T cells have proven themselves to be a powerful weapon against blood cancers, but against solid tumors they are much less effective, due in part to a process called T-cell exhaustion.

2 Dec 2021

Immune cells play a much larger role in the onset of allergies than previously thought

A ground-breaking discovery from the Malaghan Institute has shone a light on immune cells in the skin, suggesting they play a much larger role in the onset of allergies than first thought.

2 Dec 2021

Fast-tracked human stroke drug may also be a safe and powerful defense against dementia

A human stroke drug, fast-tracked by the Food and Drug Administration and soon entering Phase 3 clinical trials, shows intriguing signs that it might also be a safe and powerful defense against Alzheimer's and other forms of dementia.

1 Dec 2021

New combination treatment enables complete tumor regression in mice with high-risk neuroblastoma

In mice with high-risk neuroblastoma, tumors disappeared in response to a new combination treatment with precision medicines, a recent study from University of Gothenburg researchers shows.

30 Nov 2021

Rare variants in high-risk autism gene can alter architecture and organization of neurons, study finds

Scientists at the University of North Carolina at Chapel Hill School of Medicine and colleagues have demonstrated that rare variants in the ANK2 gene, consistently found in individuals with autism spectrum disorder (ASD), can alter architecture and organization of neurons, potentially contributing to autism and neurodevelopmental comorbidities.

29 Nov 2021

Discovering a new gene in monkeys that could help to develop new antivirals

We spoke to Dr. Nels Elde about his latest research that led to the discovery of a new gene in monkeys that could help to develop new antivirals.

26 Nov 2021

New technique may be a significant leap forward in the understanding of human cells

Most human diseases can be traced to malfunctioning parts of a cell — a tumor is able to grow because a gene wasn't accurately translated into a particular protein or a metabolic disease arises because mitochondria aren't firing properly, for example. But to understand what parts of a cell can go wrong in a disease, scientists first need to have a complete list of parts.

24 Nov 2021

New therapeutic approach prevents growth of metastatic tumors by putting cancer cells to sleep

A new therapeutic approach prevents the growth of metastatic tumors in mice by forcing cancer cells into a dormant state in which they are unable to proliferate.

23 Nov 2021

Novel protein regulator of tumor angiogenesis may be a therapeutic target for difficult-to-treat cancers

A novel protein regulator of tumor angiogenesis, TMEM230, was recently characterized by researchers to have a role in tumor development and vascularization, with potential as a target for anti-tumor therapy in difficult-to-treat cancers such as glioblastoma.