Pathogen News and Research

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Is appropriate initial empirical antimicrobial therapy associated with lower in-hospital mortality in patients with bloodstream infections?

Researchers estimated the association between the receipt of appropriate initial empirical antibiotic treatment and in-hospital death among individuals hospitalized with BSI (bloodstream infections).

6 Jan 2023

Trends in antibiotic resistance for the priority bacterial pathogens in children and adults

Researchers assessed the variation in antibiotic resistance patterns in adults and children.

5 Jan 2023

Evolutionary advantage of jumping genes in a fungus discovered

A fungus that infects salamanders contains multiple copies of the same "jumping genes", scientists have discovered.

4 Jan 2023

Bacterial outer membrane vesicles: utility as vaccines and novel engineering approaches

Scientists have described the utility of gram-negative bacteria-derived outer membrane vesicles as vaccines and methods to expand their applications.

3 Jan 2023

Study reveals a previously unappreciated complexity of TRM cell biology in the gut

Recent pressure to maximize vaccine efficacy has stirred up many new discoveries within immunology, revealing numerous paradigms with untapped therapeutic potential.

28 Dec 2022

Study reveals why some germinal centers persist for months rather than weeks

If B cells are the munitions factories of the immune system, manufacturing antibodies to neutralize harmful pathogens, then the tiny biological structures known as germinal centers are its weapons-development facilities.

23 Dec 2022

Children less likely to transmit infectious particles, study finds

Infectious diseases are often transmitted via particles exhaled from infected persons. Yet, the size of such aerosol particles varies greatly, depending on its origin in the respiratory tract.

22 Dec 2022

Cystic fibrosis drug shows promise to treat pneumonia

Pathogens such as SARS-CoV-2 and pneumococcus can cause severe pneumonia. If the airways then fill with fluid, the patient risks developing acute respiratory distress syndrome.

22 Dec 2022

New methods can advance the development of rapid diagnostics for many infectious diseases

Two companion studies report new artificial intelligence approaches for identification of molecular "fingerprints" for specific infections. The methods, used here to derive a fingerprint for COVID-19, can advance the development of rapid diagnostics for many infectious diseases.

21 Dec 2022

UMass Amherst microbiologist receives NIH grant to develop more effective treatments for tuberculosis

A microbiologist at the University of Massachusetts Amherst has received a National Institutes of Health grant to support research aimed ultimately at developing new, more effective treatments for tuberculosis (TB).

21 Dec 2022

Withdrawal of COVID-19 mitigation measures resulted in a rebound in Streptococcus pneumoniae cases in Germany

Researchers from Germany conducted a population-based surveillance study to ascertain the etiology of community acquired pneumonia (CAP) during the re-emergence of viral and bacterial respiratory diseases after the relaxation of coronavirus disease 2019 (COVID-19) containment and mitigation measures.

20 Dec 2022

Study finds several flavor/fragrance compositions that inhibit vRBD-hACE2 binding

A study describes the antiviral activity of flavor/fragrance compositions against SARS-CoV-2.

20 Dec 2022

Immune-evading Mycobacterium tuberculosis prevents inflammatory responses by hijacking the host’s ubiquitin

A new study discussed the findings of Chai et al., which revealed that triple specificity protein phosphatase (ptpB) secreted by Mycobacterium tuberculosis inhibits pyroptosis and the release of cytokines by macrophages, allowing M. tuberculosis to invade the immune system.

19 Dec 2022

Pathogen News and Research

Is appropriate initial empirical antimicrobial therapy associated with lower in-hospital mortality in patients with bloodstream infections?

Trends in antibiotic resistance for the priority bacterial pathogens in children and adults

Evolutionary advantage of jumping genes in a fungus discovered

Bacterial outer membrane vesicles: utility as vaccines and novel engineering approaches

Study reveals a previously unappreciated complexity of TRM cell biology in the gut

Study reveals why some germinal centers persist for months rather than weeks

Children less likely to transmit infectious particles, study finds

Cystic fibrosis drug shows promise to treat pneumonia

New methods can advance the development of rapid diagnostics for many infectious diseases

UMass Amherst microbiologist receives NIH grant to develop more effective treatments for tuberculosis

Withdrawal of COVID-19 mitigation measures resulted in a rebound in Streptococcus pneumoniae cases in Germany

Study finds several flavor/fragrance compositions that inhibit vRBD-hACE2 binding

Immune-evading Mycobacterium tuberculosis prevents inflammatory responses by hijacking the host’s ubiquitin

Seasonal influenza activity remains high but appears to be declining in some areas of the US

Modulation of insect immunity to control vector-borne diseases

Cryo-electron microscopy reveals atomic structure of Staphylococcus epidermidis bacteriophage

mRNA vaccine methodologies: Production, value and spectrometer use

Sheep milk could be an inexpensive source of therapeutic polyclonal SARS-CoV-2 neutralizing antibodies

Study reveals why humans get infected by rodent-borne pathogens

Globally, COVID-19 mortality biomarkers have varied efficacy

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