Understanding the relationship between SARS-CoV-2 infection and periodontitis

By Pooja Toshniwal PahariaFeb 7 2023Reviewed by Aimee Molineux

In a recent review published in the journal International Journal of Molecular Sciences, researchers reviewed existing data on the association between periodontitis and coronavirus disease 2019 (COVID-19).

Periodontitis refers to chronic inflammation and deterioration of periodontal tissues associated with plaque and calculus formation, resulting in reduced masticatory efficacy, altered speech, and reduced quality of life. Periodontal disease has been shown epidemiologically to increase the risk of chronic noncommunicable diseases such as coronary heart disease and cancer.

Periodontitis can reportedly aggravate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, and COVID-19-associated hyperinflammation could worsen periodontal illness. Therefore, improving understanding of SARS-CoV-2 infections and periodontitis immunopathogenesis may aid in developing therapeutic interventions that may improve the outcomes of both conditions.

In the present review, researchers described the similarities in the immunopathogenesis of COVID-19 and periodontitis and explored the association between the two conditions.

Study: Periodontitis and COVID-19: Immunological Characteristics, Related Pathways, and Association. Image Credit: Algirdas Gelazius / Shutterstock

Similarities in COVID-19 and periodontitis immunopathology

Periodontal pathogen components such as peptidoglycans and lipopolysaccharides activate pattern recognition receptors (PRRs), including toll-like receptors (TLRs), and subsequently, the myeloid differentiation primary response 88 (MyD88)/nuclear factor kappa B (NF-κB) pathway is activated. Likewise, SARS-CoV-2 activates the nuclear factor-kappa B through the angiotensin II receptor type 1 (AT1R)/NF-κB and TLRs/MyD88/NF-κB pathways. Nuclear factor-kappa B activation results in elevated pro-inflammatory chemokines, adhesion molecules, and cytokines levels.

Periodontal peptidoglycans and lipopolysaccharides activate toll-like receptor 2/nuclear factor kappa B and toll-like receptor 4/nuclear factor kappa B pathways, respectively. SARS-CoV-2 binds to the angiotensin-converting enzyme 2 (ACE2) receptor or transmembrane serine protease 2 (TMPRSS2) to enter into the host cells and activate the toll-like receptor 3 and mitochondrial antiviral-signaling protein (MAVS).

Subsequently, nuclear factor-kappa B signaling pathways and the NLR family pyrin domain containing 3 (NLRP3) inflammasomes are activated. Caspase 1 gets activated during inflammasome generation, and cleaves pro-interleukin (IL)-1β, pro-interleukin-18, and gasdermin D (GSDMD). The subsequent secretion of interleukin-1β, interleukin-18, and gasdermin D induce pyroptosis and inflammation.

Imterleukin-6 signaling pathways are activated in periodontitis and SARS-CoV-2 infections. Interleukin-6 signaling in COVID-19 and periodontitis may be of the classical type, trans-signaling type, or cluster type. Periodontitis-causing pathogenic organisms induce interleukin-6- and interleukin-23-dependent pathological helper T 17 (T_H17) lymphocyte accumulation, driving alveolar bone resorption and periodontitis.

SARS-CoV-2 induces interleukin-6 interleukin-23-dependent pathological T_H17 lymphocyte expression, a few of which persist in pulmonary tissues by converting into tissue-resident memory T 17 (T_RM17) lymphocytes. The T_H17 and T_RM17 lymphocytes induce hyperinflammation in response to the elevated cytokine expression with the release of interleukin-17.

Relationship between SARS-CoV-2 infections and periodontitis

SARS-CoV-2 might directly invade and infect the oral cavity, resulting in widespread clinical presentations, including necrotic periodontal diseases. Chronic inflammation resulting from periodontitis could enhance COVID-19 susceptibility, with probable aggregation of SARS-CoV-2 infections and generalized inflammation.

Periodontitis and COVID-19 share comorbidities such as hypertension, obesity, diabetes, cardiovascular diseases, chronic obstructive pulmonary disease (COPD), chronic renal disease, chronic hepatic disease, cancer, immunologic disease, human immunodeficiency virus (HIV) infections, and atherosclerotic diseases. Other factors that may increase the risk of periodontitis and SARS-CoV-2 infections include being male, smoking habits, and excessive alcohol intake.

Periodontal microbes facilitate COVID-19 by increasing ACE2 expression and the secretion of proteases that increase SARS-CoV-2 virulence. Periodontal microbes may invade the lower airways through aspiration from the oral cavity. Studies have reported that the upper airway and oral symbiotic bacterial counts are elevated in the pulmonary tissues of SARS-CoV-2-positive individuals. Pro-inflammatory chemokines and cytokines are expressed in the lower airways in response to periodontal disease, which may enhance COVID-19 severity.

The severity of periodontal disease has shown direct correlations with the severity of pulmonary impairments. On the other hand, severe COVID-19 has been associated with unfavorable periodontitis. In addition, periodontal disease may induce generalized inflammation and aggravate COVID-19-associated hyperinflammation.

Necrotic periodontal disease may be observed in SARS-CoV-2-infected individuals, due to underlying systemic inflammation, given necrotizing ulcerative gingivitis is usually observed among HIV-positive immunosuppressed individuals. Further, COVID-19 has increased psychological stress and deteriorated the mental health of the affected individuals, and stress is an established risk factor for periodontal disease. Stress-associated cortisol increase leads to immunological dysfunction, including upregulated expression of interleukin-17, the driver of inflammation-associated loss of alveolar bone.

Conclusion

Based on the review findings, COVID-19 and periodontitis may have a bidirectional relationship. Good periodontal care may aid in COVID-19 prevention, lower systemic inflammation, and therefore improve COVID-19 outcomes. Common risk factors such as smoking and excessive alcohol consumption can be targeted to improve periodontal health and COVID-19 status. In addition, stress and immunological modulation during COVID-19 could improve periodontal health.