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Revving up COVID mRNA vaccines: Algorithm generates 128-fold increase in antibodies

Research paper proposes a new method for predicting highly expressed genes based on codon usage bias and minimum free energy of mRNA secondary structures. The method involves constructing a stochastic grammar that generates sequences with high CAI and low MFE, and testing it on two mRNA vaccines.

3 May 2023

In the first 6 months after a stroke, is there an association between physical activity trajectories and functional recovery?

Researchers examined the association between physical activity in stroke patients and functional recovery.

3 May 2023

New technology can deliver gene therapy directly to the lung

Scientists at UMass Chan Medical School have developed a technology to deliver gene therapy directly to lung tissue through intranasal administration, a development that could potentially create a new class of treatments for lung disease.

2 May 2023

Research develops unique delivery system to treat osteosarcoma

New research has identified a potential therapeutic target and developed a unique delivery system to treat osteosarcoma, a bone cancer that primarily affects children and adolescents.

27 Apr 2023

Study reveals ERK signaling as a crucial molecular switch between scarring and regeneration

Why do some animals regenerate lost tissues after injury while others don't? Researchers from the lab of Kerstin Bartscherer (Osnabrück University and formerly Hubrecht Institute) and Ashley Seifert (University of Kentucky) studied spiny mice, which have a remarkable regenerative capacity, to answer this question.

26 Apr 2023

Researchers uncover the molecular basis for making long-term memories

Helping your mother make pancakes when you were three…riding your bike without training wheels…your first romantic kiss: How do we retain vivid memories of long-ago events? As described in a paper published online on April 25 in Neuron, researchers at Albert Einstein College of Medicine have found the explanation.

25 Apr 2023

Mount Sinai announces creation of the Institute for Regenerative Medicine

Regenerative medicine - the process of replacing, engineering or regenerating human cells, tissues or organs - holds exciting potential for the field of health care.

24 Apr 2023

Study reveals CMPK-2 protein-coding gene as a potent inhibitor of flaviviruses

CMPK2 identified as a potential pan-flavivirus inhibitor, restricting virus replication and providing a basis for developing new antiviral treatments.

23 Apr 2023

Researchers develop a backpack-based myeloid cell therapy for MS patients

Multiple sclerosis (MS) is a devastating autoimmune disease that destroys the protective myelin covering around nerves, disrupting communication between the brain and body, and causing patients' ability to move and function to progressively decline.

21 Apr 2023

Medical test for heart injury could be used to help COVID-19 patients avoid hospitalization

A study led by the University of St Andrews suggests that a frequently used medical test for heart injury could one day be used to help COVID-19 patients avoid hospitalization.

21 Apr 2023

Using engineered stem cells to treat ALS and retinitis pigmentosa

Cedars-Sinai investigators are developing a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using engineered stem cells that may eventually lead to personalized treatments.

20 Apr 2023

New online tool shows promise for assessing dementia risk

Researchers at UNSW Sydney and Neuroscience Research Australia (NeuRA) have developed and evaluated a tool for assessing dementia risk, with promising initial results.

20 Apr 2023

Gene therapy approach can decrease intraocular pressure in pre-clinical models of glaucoma

Scientists at Trinity College Dublin today announced a significant development towards a new therapeutic treatment of glaucoma.

19 Apr 2023

Unlocking the potential of RNA lipid nanoparticles to revolutionize cancer treatment

This paper discusses the use of RNA lipid nanoparticles for cancer immunotherapy, which has shown promising results in clinical use. However, only a small percentage of patients respond to existing immunotherapies, and the paper explores opportunities for improvement.

18 Apr 2023

Translation News and Research

Revving up COVID mRNA vaccines: Algorithm generates 128-fold increase in antibodies

In the first 6 months after a stroke, is there an association between physical activity trajectories and functional recovery?

New technology can deliver gene therapy directly to the lung

Research develops unique delivery system to treat osteosarcoma

Study reveals ERK signaling as a crucial molecular switch between scarring and regeneration

Researchers uncover the molecular basis for making long-term memories

Mount Sinai announces creation of the Institute for Regenerative Medicine

Study reveals CMPK-2 protein-coding gene as a potent inhibitor of flaviviruses

Researchers develop a backpack-based myeloid cell therapy for MS patients

Medical test for heart injury could be used to help COVID-19 patients avoid hospitalization

Using engineered stem cells to treat ALS and retinitis pigmentosa

New online tool shows promise for assessing dementia risk

Gene therapy approach can decrease intraocular pressure in pre-clinical models of glaucoma

Unlocking the potential of RNA lipid nanoparticles to revolutionize cancer treatment

Study shows effectiveness, safety of stereotactic radiosurgery for NF2-related vestibular schwannomas

Radioimmunotherapy cures human non-Hodgkin lymphoma in animal model

A call for a universal definition of post-COVID-19 condition (PCC)

Highly complementary, biologically relevant protein-protein interactions can evolve entirely by chance

Is mRNA decoding in humans structurally and kinetically distinct from bacteria?

Injectable microtissue shows promise to improve neuromuscular recovery after peripheral nerve injuries

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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