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Phase 2 clinical trial launched in Thailand to evaluate IL-15 agonist as therapy to reduce HIV reservoir

The U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research last week launched a Phase 2 clinical trial in Thailand to evaluate an interleukin-15 (IL-15) superagonist, ImmunityBio's Anktiva (also called N-803), administered during acute HIV infection as an experimental therapy to target establishment of the HIV reservoir at a very early stage.

8 Apr 2021

Phase 3 clinical trial tests new treatment for brain metastases from small-cell lung cancer

A new phase 3 randomized clinical trial overseen by CU Cancer Center member Chad Rusthoven, MD, and Vinai Gondi, MD, from Northwestern University, is testing whether a new treatment approach could result in improved outcomes for patients with small cell lung cancer (SCLC) that has spread to the brain.

8 Apr 2021

Novel mRNA delivery system produces a therapeutic protein that protects neurons from ischemia

A lack of oxygen to brain tissue--known as ischemia--leads to the death of neurons, which results in stroke. Despite considerable research, there are currently no treatments that successfully prevent neuronal death.

8 Apr 2021

Targeted therapy achieves excellent outcomes, reduces side effects in high-risk Hodgkin lymphoma

Scientists are reporting results of the first frontline clinical trial to use targeted therapy to treat high-risk pediatric Hodgkin lymphoma.

8 Apr 2021

A collaborative effort to evaluate treatment of liver and pancreatic tumors

The University of Texas MD Anderson Cancer Center and TriSalus Life Sciences today announced a strategic research collaboration to evaluate the treatment of tumors of the pancreas and liver by integrating interventional delivery of SD-101.

8 Apr 2021

Eliminating racism and anti-LGBTQ policies can improve the health of black sexual minority men

Eliminating racist and anti-LGBTQ policies is essential to improving the health of Black gay, bisexual and other sexual minority men, according to a Rutgers-led research team.

8 Apr 2021

Hydrogels offer new hope for cancer treatment

Hydrogels are often used as drug delivery systems, but to be effective carriers for anti-cancer drugs, they need to be responsive to varied stimuli in the tumor microenvironment.

8 Apr 2021

Racial diversity and poverty may influence heart-failure morbidity and mortality

Race associates with the risk of death from end-stage heart failure. So, identifying the molecular determinants of that risk may help the pursuit of the novel diagnosis and prognosis of heart failure, and its therapy.

8 Apr 2021

Study offers localized treatment direction for a cause of Crohn's disease

People with Crohn's disease are typically treated with powerful anti-inflammatory medications that act throughout their body, not just in their digestive tract, creating the potential for unintended, and often serious, side effects.

7 Apr 2021

SlowMo therapy helps treat paranoid thoughts in people experiencing psychosis

A new clinical trial from King's College London's Institute of Psychiatry, Psychology, & Neuroscience, in collaboration with Oxford University, Oxford Health NHS Foundation Trust, Sussex University, and Sussex Partnership NHS Foundation Trust has established an innovative therapy as an effective means of treating paranoid thoughts in people experiencing psychosis.

7 Apr 2021

New stem cell therapy shows promise to prevent diabetes-related amputations

According to the results of a phase 1 clinical trial just published in STEM CELLS Translational Medicine, a new stem cell therapy shows promise of making diabetes-related amputations a thing of the past.

7 Apr 2021

Study: Disparities persist in prescribing comfort care for ischemic stroke patients

Receiving palliative or hospice care services was found to improve quality of life for hospitalized ischemic stroke patients, however, disparities persist in which patients are prescribed or have access to these holistic comfort care options, according to new research published today in the Journal of the American Heart Association, an open access journal of the American Heart Association.

7 Apr 2021

Novel polyclonal antibody XAV-19 efficiently neutralizes UK and South African SARS-CoV-2 variants

A promising new study reports on the high neutralizing efficacy of a polyclonal swine antibody against SARS-CoV-2, the pathogen responsible for the novel COVID-19. By demonstrating the ability of this antibody to neutralize all currently circulating viral variants, the study suggests that it is ideal for development as a new and very effective therapy for COVID-19.

7 Apr 2021

New research could rescue failed immunotherapies for treating solid tumors

New research from the UVA Cancer Center could rescue once-promising immunotherapies for treating solid cancer tumors, such as ovarian, colon and triple-negative breast cancer, that ultimately failed in human clinical trials.

7 Apr 2021

Neurotechnology combined with saliva testing improves accuracy in measuring psychoactive effects of cannabis

A new study, released today in the scientific journal Advances in Therapy is providing critical evidence that neurotechnology combined with saliva testing can drastically reduce the likelihood of falsely determining cannabis impairment due to THC residual detection.

7 Apr 2021

Individuals with Major Depressive Disorder have accelerated cellular aging

Cells from individuals with Major Depressive Disorder (MDD) were found to have higher than expected rates of methylation at specific sites on their DNA, when compared to cells from healthy individuals without MDD, according to a study by a multidisciplinary team of UC San Francisco scientists, in collaboration with others.

7 Apr 2021

Proposed network offers a simple, accurate screening tool for systemic sclerosis

The founding chair of the Biomedical Engineering Department at the University of Houston is reporting a new deep neural network architecture that provides early diagnosis of systemic sclerosis (SSc), a rare autoimmune disease marked by hardened or fibrous skin and internal organs.

7 Apr 2021

AGA’s new clinical guidelines recommend the use of IGB for obese patients

Obesity is a global pandemic, affecting about 40% of adults in the United States. There is an enormous unmet need for an effective weight-loss solution.

7 Apr 2021

Researchers discover two new ways to treat small cell lung tumors

Using samples of small cell lung tumors, a research team led by biologist Dr Silvia von Karstedt has discovered two new ways to induce tumor cell death. One of two subsets of tumor cells can be targeted by activating ferroptosis: iron-dependent cell death caused by oxidative stress

7 Apr 2021

Phase 1 clinical trial to test a new, potential method against cancer

A potential new weapon against cancer is entering the first phase of clinical trials thanks to a collaboration between Spectrum Health, the Lansing-based company Niowave and Michigan State University.

7 Apr 2021

Therapy News and Research

Phase 2 clinical trial launched in Thailand to evaluate IL-15 agonist as therapy to reduce HIV reservoir

Phase 3 clinical trial tests new treatment for brain metastases from small-cell lung cancer

Novel mRNA delivery system produces a therapeutic protein that protects neurons from ischemia

Targeted therapy achieves excellent outcomes, reduces side effects in high-risk Hodgkin lymphoma

A collaborative effort to evaluate treatment of liver and pancreatic tumors

Eliminating racism and anti-LGBTQ policies can improve the health of black sexual minority men

Hydrogels offer new hope for cancer treatment

Racial diversity and poverty may influence heart-failure morbidity and mortality

Study offers localized treatment direction for a cause of Crohn's disease

SlowMo therapy helps treat paranoid thoughts in people experiencing psychosis

New stem cell therapy shows promise to prevent diabetes-related amputations

Study: Disparities persist in prescribing comfort care for ischemic stroke patients

Novel polyclonal antibody XAV-19 efficiently neutralizes UK and South African SARS-CoV-2 variants

New research could rescue failed immunotherapies for treating solid tumors

Neurotechnology combined with saliva testing improves accuracy in measuring psychoactive effects of cannabis

Individuals with Major Depressive Disorder have accelerated cellular aging

Proposed network offers a simple, accurate screening tool for systemic sclerosis

AGA’s new clinical guidelines recommend the use of IGB for obese patients

Researchers discover two new ways to treat small cell lung tumors

Phase 1 clinical trial to test a new, potential method against cancer

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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