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The role of ARF6 in SARS-CoV-2 endocytosis and infection

Researchers assessed the role of adenoside diphosphate (ADP)-ribosylation factor 6 (ARF6) in SARS-CoV-2 infection.

14 Jun 2022

Molecular snapshots of the productive infectious entry pathway of SARS-CoV-2 into cells

In a recent study posted to the bioRxiv* pre-print server, researchers in the United States demonstrated that the acidic milieu of the nasal cavity is critical for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tropism.

14 Jun 2022

Elevated Th17 cells associated with increased risk of critical COVID

In a recent article published in the European Journal of Internal Medicine, researchers in France indicated that T cell immune reaction correlates possibly with the chance of critical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among hospitalized patients.

14 Jun 2022

Orbit Discovery awarded Innovate UK grant to expand high throughput cell-based functional screening platform capabilities in peptide drug discovery

Orbit Discovery Ltd., (“Orbit”) a privately held biopharmaceutical company focused on discovering candidate peptide therapeutics harnessing proprietary affinity and cell-based functional screening platforms, has been awarded a Smart grant by Innovate UK, the UK’s innovation agency.

From Orbit Discovery 14 Jun 2022

New approach to quantify tumor-specific total mRNA levels from patient tumor samples

Researchers at The University of Texas MD Anderson Cancer Center have developed a new approach to quantify tumor-specific total mRNA levels from patient tumor samples, which contain both cancer and non-cancer cells.

14 Jun 2022

The microbiome plays a vital role in a healthy diet

A recent study discusses the current national nutritional recommendations from the viewpoint of the gut microbiota.

14 Jun 2022

The severity of COVID-19 compared to seasonal influenza

In a recent study under review at the Archives of Virology journal and currently posted to the Research Square* preprint server, investigators in Israel assessed the disparities and similarities between seasonal influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

14 Jun 2022

Genomic analysis of the 2022 monkeypox outbreak

In a recent study posted to the bioRxiv* pre-print server, researchers analyzed two genomic sequences of the Monkeypox virus from Belgium and Portugal termed ITM001 and PT0001, respectively, to show that the May 2022 Monkeypox outbreak most likely originated from the West African clade of the virus.

14 Jun 2022

Targeting macropinocytosis may be an effective therapeutic approach for hepatocellular carcinoma

Researchers from the Department of Pathology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong (HKUMed) have identified a new metabolic mechanism in liver cancer cells, by which macropinocytosis, an endocytic process, is used to engulf extracellular proteins as fuels to support the unlimited growth of hepatocellular carcinoma (HCC) in hypoxia (oxygen deprivation).

14 Jun 2022

New project seeks to develop a microscopy system for making drug interactions in the liver visible

Bielefeld University is coordinating a new EU-research project that seeks to produce microscopic liver tissue cultures that can survive for 14 days, while also using imaging methods to investigate how liver cells react to combinations of different medications.

14 Jun 2022

OSU researchers study quorum sensing in a gram-negative bacterium that displays social behaviors

Oregon State University scientists have identified proteins that prevent a bacterial cell from becoming misguided by its own messaging, allowing it to instead wait for collective communication from its group.

13 Jun 2022

SARS-CoV-2 recombinant isolated from chronic COVID-19 patient

A new research paper in the journal Viruses reports the isolation of a recombinant strain in a patient infected with the virus for over a year.

13 Jun 2022

Sex and previous pregnancy of blood donors do not increase mortality risk of transfused patients

A study from Karolinska Institutet in Sweden sheds new light on the question of whether the sex and previous pregnancy of blood donors affects survival in patients who receive red blood cell transfusions.

13 Jun 2022

MIT researchers design new sensor to distinguish between viral and bacterial pneumonia

Many different types of bacteria and viruses can cause pneumonia, but there is no easy way to determine which microbe is causing a particular patient's illness.

13 Jun 2022

RNA exosomes play a key role in B cell development, UTSW study suggests

New research from UT Southwestern suggests that RNA exosomes – the cellular machines that degrade old molecules of RNA – play a key role in the development of B cells, which are critical to the immune system's ability to protect against infection.

13 Jun 2022

Study demonstrates a potential way to stimulate the formation of new insulin-producing cells

Researchers at Karolinska Institutet in Sweden show how a molecule that they have identified stimulates the formation of new insulin-producing cells in zebrafish and mammalian tissue, through a newly described mechanism for regulating protein synthesis.

13 Jun 2022

Study offers a new and unique treatment for AIDS

A new study from Tel Aviv University offers a new and unique treatment for AIDS which may be developed into a vaccine or a one time treatment for patients with HIV.

13 Jun 2022

Researchers demonstrate the feasibility of pancreatic beta-cell, target-specific CAR-Treg treatment for T1D

Researchers have successfully treated type 1 diabetes in mice using pancreatic beta-cell, target-specific, chimeric antigen-receptor (CAR) regulatory T cells (Tregs), and demonstrated the feasibility of their approach to treat the human condition according to data being presented Monday, June 13 at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.

13 Jun 2022

Active testosterone therapy for transgender men may worsen IVF outcomes, mouse study suggests

Active testosterone therapy for transgender men may negatively impact IVF outcomes, suggests a mouse study being presented Monday at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.

13 Jun 2022

Treatment with immunity-boosting protein enhances the function of CAR-T cells in fighting blood cancers

Advances in cellular immunotherapy that spur genetically modified T cells to attack cancer cells have revolutionized the treatment of certain blood cancers.

13 Jun 2022

B Cell News and Research

The role of ARF6 in SARS-CoV-2 endocytosis and infection

Molecular snapshots of the productive infectious entry pathway of SARS-CoV-2 into cells

Elevated Th17 cells associated with increased risk of critical COVID

Orbit Discovery awarded Innovate UK grant to expand high throughput cell-based functional screening platform capabilities in peptide drug discovery

New approach to quantify tumor-specific total mRNA levels from patient tumor samples

The microbiome plays a vital role in a healthy diet

The severity of COVID-19 compared to seasonal influenza

Genomic analysis of the 2022 monkeypox outbreak

Targeting macropinocytosis may be an effective therapeutic approach for hepatocellular carcinoma

New project seeks to develop a microscopy system for making drug interactions in the liver visible

OSU researchers study quorum sensing in a gram-negative bacterium that displays social behaviors

SARS-CoV-2 recombinant isolated from chronic COVID-19 patient

Sex and previous pregnancy of blood donors do not increase mortality risk of transfused patients

MIT researchers design new sensor to distinguish between viral and bacterial pneumonia

RNA exosomes play a key role in B cell development, UTSW study suggests

Study demonstrates a potential way to stimulate the formation of new insulin-producing cells

Study offers a new and unique treatment for AIDS

Researchers demonstrate the feasibility of pancreatic beta-cell, target-specific CAR-Treg treatment for T1D

Active testosterone therapy for transgender men may worsen IVF outcomes, mouse study suggests

Treatment with immunity-boosting protein enhances the function of CAR-T cells in fighting blood cancers

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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