Precision Medicine News and Research

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Cleveland Clinic’s ROBIN center may pave way for more effective radiation, immunotherapy treatments

Cleveland Clinic received a $7.9 million five-year grant from the National Cancer Institute at the National Institutes of Health to form one of three national centers as part of the newly established Radiation Oncology-Biology Integration Network (ROBIN).

22 Sep 2022

Human gene variant in ADHD, autism exposes sex-dependence of neuronal signaling mechanisms

The prevalence, age of onset, and clinical symptoms for virtually all neuropsychiatric disorders differ between men and women. Among the disorders with pronounced sex bias are Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD), where the ratio of males/females diagnosed is approximately 4 to 1.

21 Sep 2022

Large clinical trial compares four drugs commonly used to treat type 2 diabetes

In a large clinical trial that directly compared four drugs commonly used to treat type 2 diabetes, researchers found that insulin glargine and liraglutide performed the best of four medications approved by the U.S. Food and Drug Administration to maintain blood glucose levels in the recommended range.

21 Sep 2022

Mutation in newly discovered small protein linked to increase in Alzheimer's disease risk

A mutation in a newly discovered small protein is connected to a significant increase in the risk for Alzheimer's disease, expanding the known gene targets for the disease and presenting a new potential avenue for treatment, according to a new USC study.

21 Sep 2022

UC San Diego team receives $1.2 million to create a novel system to study chronic low back pain

A multidisciplinary team led by researchers at UC San Diego has received $1.2 million from the National Science Foundation to create a novel system to study and inform the treatment of chronic low back pain.

20 Sep 2022

New genomic test can predict a patient's risk of developing severe COVID-19, research suggests

A genomic test being developed by a Charlottesville, Va., company can predict a patient's risk of developing severe COVID-19, new research from UVA Health suggests.

16 Sep 2022

Study shows differences in treatment outcomes for Black vs. white women with hormone receptor-positive breast cancer

A study led by City of Hope, one of the largest cancer research and treatment organizations in the United States, found that Black women with Stage 1 or 2 breast cancer were almost three times more likely than white women to have tumor shrinkage from hormone therapy delivered prior to surgery, yet Black women were more likely than their white counterparts to have worse outcomes when this type of endocrine therapy before surgery was used at a later stage of disease.

16 Sep 2022

STRATAGEM aims to provide new perspectives on multidrug-resistant solid tumors

Achieving a good efficacy of chemotherapy is one of the major challenges still unresolved in oncological patients. The main limitation to the efficacy of chemotherapy is the multidrug-resistant (MDR) phenotype, a multiple cross-resistance towards different anticancer drugs.

14 Sep 2022

Scientists identify two distinct subtypes of obesity

A team led by Van Andel Institute scientists has identified two distinct types of obesity with physiological and molecular differences that may have lifelong consequences for health, disease and response to medication.

14 Sep 2022

New drug marks cancer cells for destruction by the immune system

Tumor cells are notoriously good at evading the human immune system; they put up physical walls, wear disguises and handcuff the immune system with molecular tricks.

13 Sep 2022

UC San Diego selected to lead components of the NIH Common Fund's Bridge2AI program

Researchers at University of California San Diego School of Medicine have been selected to lead components of the National Institutes of Health (NIH) Common Fund's Bridge to Artificial Intelligence (Bridge2AI) program.

13 Sep 2022

Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

The highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses across multiple tumor types in the Phase I/II LIBRETTO-001 trial, according to researchers from The University of Texas MD Anderson Cancer Center.

13 Sep 2022

Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

12 Sep 2022

Study reveals two distinct types of obesity with physiological and molecular differences

12 Sep 2022

Low-dose ketamine is safe and effective to treat children with ADNP syndrome, study suggests

Results of a small, but unique research study, led by researchers from the Seaver Autism Center for Research and Treatment at Mount Sinai and published online in Human Genetics and Genomic Advances, suggest that low-dose ketamine is generally safe, well-tolerated and effective to treat clinical symptoms in children diagnosed with ADNP syndrome (also known as Helsmoortel-VanDerAa syndrome), a rare neurodevelopmental disorder caused by mutations in the activity dependent neuroprotective protein (ADNP) gene.

6 Sep 2022

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

Scientists have created a roadmap of the genetic mutations present in the most common childhood cancer, acute lymphoblastic leukemia (ALL).

1 Sep 2022

Integrating recent advances in multi-omics tumor profiling into precision cancer treatment

Tumors have significant differences depending on the person affected, even if they are the same cancer, such as breast cancer.

1 Sep 2022

SARS-CoV-2 antigen levels associated with COVID-19 severity and other clinical outcomes

The amount of SARS-CoV-2 antigen measured in the blood of patients hospitalized with COVID-19 is associated with illness severity and other clinical outcomes, according to a new study published in the Annals of Internal Medicine.

29 Aug 2022

FAU and Tel Aviv researchers receive grant to tackle Alzheimer’s-related mood disorders

Alzheimer's disease (AD) is the most common type of dementia affecting an estimated 6.3 million Americans age 65 and older. Without the development of medical breakthroughs to prevent, treat, slow or cure AD that number could grow to 13.8 million by 2060.

29 Aug 2022

Researchers receive $1.2 million Keck Foundation grant to find molecules for targeting the 'undruggable proteome'

The W.M. Keck Foundation has awarded a $1.2 million grant to medicinal chemistry and computational biology researchers at the University of Kansas and the University of Chicago focused on addressing a long-unresolved problem in biomedical research - finding molecules able to target the "undruggable proteome."

29 Aug 2022

Precision Medicine News and Research

Cleveland Clinic’s ROBIN center may pave way for more effective radiation, immunotherapy treatments

Human gene variant in ADHD, autism exposes sex-dependence of neuronal signaling mechanisms

Large clinical trial compares four drugs commonly used to treat type 2 diabetes

Mutation in newly discovered small protein linked to increase in Alzheimer's disease risk

UC San Diego team receives $1.2 million to create a novel system to study chronic low back pain

New genomic test can predict a patient's risk of developing severe COVID-19, research suggests

Study shows differences in treatment outcomes for Black vs. white women with hormone receptor-positive breast cancer

STRATAGEM aims to provide new perspectives on multidrug-resistant solid tumors

Scientists identify two distinct subtypes of obesity

New drug marks cancer cells for destruction by the immune system

UC San Diego selected to lead components of the NIH Common Fund's Bridge2AI program

Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

Study reveals two distinct types of obesity with physiological and molecular differences

Low-dose ketamine is safe and effective to treat children with ADNP syndrome, study suggests

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

Integrating recent advances in multi-omics tumor profiling into precision cancer treatment

SARS-CoV-2 antigen levels associated with COVID-19 severity and other clinical outcomes

FAU and Tel Aviv researchers receive grant to tackle Alzheimer’s-related mood disorders

Researchers receive $1.2 million Keck Foundation grant to find molecules for targeting the 'undruggable proteome'

Event guide: The 4th Precision Medicine in Inflammatory Bowel Disease Summit eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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