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Greenwich Hospital partners with ONSF to conduct research on surgical site infections

Research on surgical site infections conducted at Greenwich Hospital in alliance with the ONS Foundation for Clinical Research and Education examined why a certain bacteria is so common in post-surgical shoulder infections and are helping to develop tactics to control it.

7 Nov 2014

Integrative medicine therapies can decrease pain, anxiety for hospitalized cancer patients

Pain is a common symptom of cancer and side effect of cancer treatment, and treating cancer-related pain is often a challenge for health care providers.

7 Nov 2014

Obeticholic acid improves liver health in people with nonalcoholic steatohepatitis

An experimental drug aimed at treating a common liver disease showed promising results and potential problems in a multicenter clinical trial funded by the National Institutes of Health. The FLINT study found that people with nonalcoholic steatohepatitis (NASH) who took obeticholic acid (OCA) had improved liver health during that period, including decreased inflammation and fat in the liver and decreased body weight versus people receiving a placebo. OCA was also associated with increases in itching and total cholesterol.

7 Nov 2014

Olaparib shows promise for advanced cancers associated with BRCA1 and BRCA2 mutations

Olaparib, an experimental twice-daily oral cancer drug, produces an overall tumor response rate of 26 percent in several advanced cancers associated with BRCA1 and BRCA2 mutations, according to new research co-led by the Abramson Cancer Center of the University of Pennsylvania.

7 Nov 2014

Journal highlights health outcomes of women veterans

In honor of Veterans Day, the peer-reviewed journal Women's Health Issues (WHI) today released a new Special Collection on women veterans' health, with a focus on mental health. The special collection also highlights recent studies addressing healthcare services, reproductive health and cardiovascular health of women veterans.

7 Nov 2014

New study explains role of cilia in type 2 diabetes

Tiny extensions on cells, cilia, play an important role in insulin release, according to a new study, which is published in Nature Communications. The researchers report that the cilia of beta cells in the pancreas are covered with insulin receptors and that changed ciliary function can be associated with the development of type 2 diabetes.

7 Nov 2014

Low subjective social status linked to mental disorder risk

Researchers report an inverse association between people’s subjective social status (SSS) and the likelihood of them having a psychiatric disorder.

6 Nov 2014

U-M researchers show how neurons perform multiple functions

Researchers at the University of Michigan have shown how a single neuron can perform multiple functions in a model organism, illuminating for the first time this fundamental biological mechanism and shedding light on the human brain.

6 Nov 2014

Scientists develop human stem cell disease model of Parkinson's disease in a dish

A team of scientists led by The New York Stem Cell Foundation Research Institute successfully created a human stem cell disease model of Parkinson's disease in a dish. Studying a pair of identical (monozygotic) twins, one affected and one unaffected with Parkinson's disease, another unrelated Parkinson's patient, and four healthy control subjects, the scientists were able to observe key features of the disease in the laboratory, specifically differences in the patients' neurons' ability to produce dopamine, the molecule that is deficient in Parkinson's disease.

6 Nov 2014

Osteoporosis drugs may also benefit patients with tumours outside the skeleton

Australian researchers have shown why calcium-binding drugs commonly used to treat people with osteoporosis, or with late-stage cancers that have spread to bone, may also benefit patients with tumours outside the skeleton, including breast cancer.

6 Nov 2014

Scientists awarded grant to investigate new drug-based treatment for NF2

Scientists from Plymouth University Peninsula Schools of Medicine and Dentistry have been awarded a grant from young person's cancer charity The Laura Crane Youth Cancer Trust to investigate a new drug-based treatment for a multi-tumour brain and nervous system cancer which affects teenagers and young adults.

6 Nov 2014

Researchers develop 'smart bomb' to attack B-lineage ALL

Fatih Uckun, Jianjun Cheng and their colleagues have taken the first steps towards developing a so-called "smart bomb" to attack the most common and deadly form of childhood cancer — called B-lineage acute lymphoblastic leukemia (ALL).

6 Nov 2014

MMRF initiative aims to speed up evaluation of new investigational drugs for multiple myeloma

The Multiple Myeloma Research Foundation today announced an initiative designed to accelerate the evaluation of new investigational therapies for multiple myeloma (MM).

6 Nov 2014

Johns Hopkins researchers capture images of protein complex that keeps hearts beating

For years, a multidisciplinary team of Johns Hopkins researchers has tracked an elusive creature, a complex of proteins thought to be at fault in some cases of sudden cardiac death. As they report Nov. 5 in the online edition of Nature Communications, they have finally captured images of the complex.

6 Nov 2014

Study sheds light on DCIS recurrence

Work by University of Manchester scientists has explored what allows some cases of Ductal Carcinoma in Situ (DCIS), a non-invasive form of breast cancer, to resist treatment and come back, as well as identifying a potential new target to improve the effectiveness of radiotherapy.

6 Nov 2014

UCSD engineers propose new single-ventricle heart surgery for children

Engineers at the University of California, San Diego, are proposing a new surgical intervention for children born with a single ventricle in their heart--instead of the usual two. The new approach would potentially reduce the number of surgeries the patients have to undergo in the first six months of life from two to just one. If successful, it would also create a more stable circuit for blood to flow from the heart to the lungs and the rest of the body within the first days and months of life.

6 Nov 2014

Isis receives $10 million from Biogen Idec to initiate IND-supporting studies of ISIS-BIIB3 Rx

Isis Pharmaceuticals, Inc. announced today that it has earned a $10 million milestone payment from Biogen Idec related to the initiation of investigational new drug (IND)-supporting studies of ISIS-BIIB3Rx. ISIS-BIIB3Rx is a recently identified development candidate designed to inhibit an undisclosed target to treat a neurodegenerative disease.

6 Nov 2014

Researchers develop diagnostic tool to examine traveling cancer cells, improve health outcomes

For most cancer patients, primary tumours are often not the most deadly. Instead, it is the metastatic tumours - tumours that spread from their original location to other parts of the body - that are the cause of most cancer deaths.

6 Nov 2014

Joslin researcher identifies molecular pathway that causes neural tube defects in diabetic pregnancies

Mary R. Loeken, Ph.D., Investigator in the Section on Islet Cell and Regenerative Biology at Joslin Diabetes Center and Associate Professor of Medicine at Harvard Medical School, has discovered a molecular pathway responsible for neural tube defects in diabetic pregnancies. Her latest research findings in this pathway were published in the October issue of Diabetes.

6 Nov 2014

Discovery Laboratories reports net loss of $11.3 million for third quarter 2014

Discovery Laboratories, Inc., a specialty biotechnology company dedicated to advancing a new standard in respiratory critical care, today announced financial results for the third quarter ended September 30, 2014, as well as recent business updates.

6 Nov 2014

Research News and Research

Greenwich Hospital partners with ONSF to conduct research on surgical site infections

Integrative medicine therapies can decrease pain, anxiety for hospitalized cancer patients

Obeticholic acid improves liver health in people with nonalcoholic steatohepatitis

Olaparib shows promise for advanced cancers associated with BRCA1 and BRCA2 mutations

Journal highlights health outcomes of women veterans

New study explains role of cilia in type 2 diabetes

Low subjective social status linked to mental disorder risk

U-M researchers show how neurons perform multiple functions

Scientists develop human stem cell disease model of Parkinson's disease in a dish

Osteoporosis drugs may also benefit patients with tumours outside the skeleton

Scientists awarded grant to investigate new drug-based treatment for NF2

Researchers develop 'smart bomb' to attack B-lineage ALL

MMRF initiative aims to speed up evaluation of new investigational drugs for multiple myeloma

Johns Hopkins researchers capture images of protein complex that keeps hearts beating

Study sheds light on DCIS recurrence

UCSD engineers propose new single-ventricle heart surgery for children

Isis receives $10 million from Biogen Idec to initiate IND-supporting studies of ISIS-BIIB3 Rx

Researchers develop diagnostic tool to examine traveling cancer cells, improve health outcomes

Joslin researcher identifies molecular pathway that causes neural tube defects in diabetic pregnancies

Discovery Laboratories reports net loss of $11.3 million for third quarter 2014

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