Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Chemical compounds containing special metals can fight fungal infections

An international collaboration led by researchers from the University of Bern and the University of Queensland in Australia has demonstrated that chemical compounds containing special metals are highly effective in fighting dangerous fungal infections.

23 Sep 2022

Study shows 72% increase in new diagnoses of type 1 diabetes in young COVID-19 patients

Children who were infected with COVID-19 show a substantially higher risk of developing type 1 diabetes (T1D), according to a new study that analyzed electronic health records of more than 1 million patients ages 18 and younger.

23 Sep 2022

Scientists uncover key details of an immune-cell process that underlies excessive inflammation

A team led by Scripps Research scientists has uncovered key details of an immune-cell process that frequently underlies excessive inflammation in the body.

22 Sep 2022

New modeling system identifies potential therapeutics for autosomal recessive polycystic kidney disease

Organoids - lab grown cells or tissues that resemble organs - serve as a new tool for disease modeling, but researchers often have difficulty replicating the biophysical conditions in which the organs operate within the body.

22 Sep 2022

SARS-CoV-2 viral infection is associated with an increased risk of Alzheimer’s disease

Older people who were infected with COVID-19 show a substantially higher risk - as much as 50% to 80% higher than a control group - of developing Alzheimer's disease within a year, according to a study of more than 6 million patients 65 and older.

14 Sep 2022

The use of AlphaFold2-enabled molecular docking simulations to predict protein-ligand interactions for antibiotic drug discovery

Researchers demonstrated that advances in modeling protein-ligand interactions using machine learning-based approaches are needed to exploit AlphaFold2 for antibiotic discovery better.

9 Sep 2022

New agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease

A newly developed agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease, signaling its promise as a potential treatment for the disease, according to a team of researchers at UTHealth Houston.

8 Sep 2022

Study helps reveal the molecular secrets of macular degeneration

Research led by Sanford Burnham Prebys professor Francesca Marassi, Ph.D., is helping to reveal the molecular secrets of macular degeneration, which causes almost 90% of all age-related vision loss.

7 Sep 2022

Creoptix launches new WAVEcontrol software to deliver automated, flexible and intuitive label-free interaction analysis for biologics drug-discovery

Creoptix® (a Malvern Panalytical brand) is announcing the addition of two new wizards to their WAVEcontrol software to simplify and streamline workflows. By combining the high sensitivity, throughput, and no-clog microfluidics of the WAVEsystem, with a faster, more flexible, automated approach to screening and characterization, Creoptix is accelerating biologics drug discovery and diagnostics development.

From Malvern Panalytical 7 Sep 2022

Advances in modeling molecular interactions needed to better harness AlphaFold for drug discovery

Over the past few decades, very few new antibiotics have been developed, largely because current methods for screening potential drugs are prohibitively expensive and time-consuming.

6 Sep 2022

PhoreMost enters multi-project drug target discovery collaboration with Roche

PhoreMost to deploy its SITESEEKER platform to identify novel targets for Roche’s discovery programmes

From PhoreMost 6 Sep 2022

Bringing flexibility to Sanger sequencing and DNA-fragment analysis with the Spectrum Compact CE System

In this interview, News Med is talking to Gabriela Saldanha about DNA Fragmentation and Sanger Sequencing.

From Promega Corporation 5 Sep 2022

Novel tool evaluates the contractile force-related state of myotubes

Researchers from Tokyo Metropolitan University have developed a way to characterize the force generated by contracting myotubes, precursors to skeletal muscle fiber, combining electrostimulation and analysis of wrinkles in the silicone substrate on which they are mounted. Existing methods rely on muscle mass or the expression of certain proteins, both not as strongly correlated with muscle strength. Accurate measurement of myotube strength promises more effective screening of drug targets for treating muscle atrophy.

5 Sep 2022

Inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth

Researchers at Sanford Burnham Prebys, led by Ze'ev Ronai, Ph.D., have shown for the first time that inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth.

1 Sep 2022

Disrupting a virus’s genome packaging can halt replication, study finds

Like savvy international travelers, viruses know exactly how to pack. With the genetic instructions for the next generation folded just so, snuggled into a custom-made outer covering studded with cell-grabbing proteins, these tiny invaders quest for new digs on the reg.

30 Aug 2022

Using organic metal nanohybrid structures to simultaneously identify multiple food poisoning bacteria

Osaka Metropolitan University scientists have developed a simple, rapid method to simultaneously identify multiple food poisoning bacteria, based on color differences in the scattered light by nanometer-scaled organic metal nanohybrid structures (NHs) that bind via antibodies to those bacteria.

29 Aug 2022

Researchers identify multiple genes and rare variants linked with Crohn's disease susceptibility

An international consortium of researchers has identified genetic variants in 10 genes that elevate a person's susceptibility to Crohn's disease, a form of inflammatory bowel disease.

29 Aug 2022

Researchers receive $1.2 million Keck Foundation grant to find molecules for targeting the 'undruggable proteome'

The W.M. Keck Foundation has awarded a $1.2 million grant to medicinal chemistry and computational biology researchers at the University of Kansas and the University of Chicago focused on addressing a long-unresolved problem in biomedical research - finding molecules able to target the "undruggable proteome."

29 Aug 2022

COVID-19 pandemic: An epidemiological update

Epidemics and pandemics have been frightening the human chase again and again. SARS, H1N1, Ebola, and more have exposed their real face in the past, but with every such outbreak.

25 Aug 2022

Using AI to foster productivity in pharmaceutical research and development

As part of our SLAS Europe 2022 coverage, we speak to Sree Vadlamudi from Iktos, about how we can adopt AI to help foster productivity within pharmaceutical research.

From Society for Laboratory Automation and Screening (SLAS) 25 Aug 2022

Drug Discovery News and Research

Further Reading

Chemical compounds containing special metals can fight fungal infections

Study shows 72% increase in new diagnoses of type 1 diabetes in young COVID-19 patients

Scientists uncover key details of an immune-cell process that underlies excessive inflammation

New modeling system identifies potential therapeutics for autosomal recessive polycystic kidney disease

SARS-CoV-2 viral infection is associated with an increased risk of Alzheimer’s disease

The use of AlphaFold2-enabled molecular docking simulations to predict protein-ligand interactions for antibiotic drug discovery

New agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease

Study helps reveal the molecular secrets of macular degeneration

Creoptix launches new WAVEcontrol software to deliver automated, flexible and intuitive label-free interaction analysis for biologics drug-discovery

Advances in modeling molecular interactions needed to better harness AlphaFold for drug discovery

PhoreMost enters multi-project drug target discovery collaboration with Roche

Bringing flexibility to Sanger sequencing and DNA-fragment analysis with the Spectrum Compact CE System

Novel tool evaluates the contractile force-related state of myotubes

Inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth

Disrupting a virus’s genome packaging can halt replication, study finds

Using organic metal nanohybrid structures to simultaneously identify multiple food poisoning bacteria

Researchers identify multiple genes and rare variants linked with Crohn's disease susceptibility

Researchers receive $1.2 million Keck Foundation grant to find molecules for targeting the 'undruggable proteome'

COVID-19 pandemic: An epidemiological update

Using AI to foster productivity in pharmaceutical research and development

Event guide: World ADC Asia eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo