Platelets News and Research

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New approaches to counteract platelet shortages

Availability of safe platelets is a fundamental blood transfusion challenge and can be especially problematic in times of emergency. Several studies presented at the annual American Association of Blood Banks (AABB) meeting today demonstrate new approaches to counteract platelet shortages by enhancing the safety of whole blood derived platelets, precluding the need to rely on only those obtained through apheresis.

17 Oct 2005

Gel made from a patient's own blood reduces pain and may improve wound healing

The study, published in the September issue of the Annals of Otology, Rhinology and Laryngology, found that patients who received platelet gel reported an easier recovery than patients who received traditional packing to stop bleeding.

13 Oct 2005

Moderate drinking has effects on blood coagulation, primarily as a "blood thinner"

Population studies have shown that moderate drinkers tend to have lower rates of heart disease but higher rates of bleeding-type strokes than abstainers. A potential mediator of these two contrasting effects of alcohol may be platelet function.

13 Oct 2005

Dental problems caused by radiation, chemotherapy should be treated before a child undergoes immunosuppression as part of bone marrow transplantation therapy

Many children who undergo bone marrow transplantation (BMT) as part of cancer treatment already have dental abnormalities that leave them vulnerable to potentially life-threatening bacterial infections, according to investigators at St. Jude Children's Research Hospital. A report on this study appears in the prepublication online edition of Bone Marrow Transplantation.

29 Aug 2005

Pre-mRNA that codes for inflammatory protein identified

In a discovery that upends a longstanding tenet of human biology, University of Utah School of Medicine researchers have shown that a key process in gene regulation can occur in human platelets, unique cells that are unusual because they don't have a nucleus (anucleate).

11 Aug 2005

Drinking a cup of cocoa can prevent potentially fatal blood clots

Throughout history, cocoa has been described as a medicine for many ailments. New research suggests that cocoa may also have a beneficial effect on heart disease and stroke.

9 Aug 2005

European approval of Temodal (temozolomide) capsules for treatment of glioblastoma multiforme

Schering-Plough announced today that the European Commission has granted approval of Temodal (temozolomide) Capsules for first-line use for the treatment of patients with newly diagnosed glioblastoma multiforme (GBM), the most common and aggressive form of primary brain cancer.

10 Jun 2005

Study shows how COX-2 inhibitors lead to heart disease

University of Pennsylvania School of Medicine researchers have found additional evidence that may help explain how selective inhibitors of COX-2 might predispose individuals to heart disease and stroke.

26 May 2005

Zevalin safe and effective for non-Hogdkin's lymphoma patients

According to a University of Pittsburgh Medical Center (UPMC) study, patients with advanced non-Hodgkin's lymphoma (NHL) previously treated with chemotherapy and adult stem cell transplantation can safely tolerate Zevalin (ibritumomab tiuxetan), a radiolabeled monoclonal antibody that targets radiation directly to a tumor.

17 May 2005

New predictor for blood transplant success

The success of blood stem cell transplants used to treat diseases such as leukemia, Hodgkin’s lymphoma and aplastic anemia may soon become more predictable, thanks to a discovery made by researchers at the University of British Columbia.

11 May 2005

Specific variants of genes predict bleeding after heart surgery

Duke University Medical Center researchers have found that the presence of specific variants of genes that control clotting and the contractility, or "tone," of blood vessels can double the ability of physicians to predict those heart surgery patients at greatest risk of bleeding after surgery.

4 May 2005

Specific genes play key role in the of regulation of human-blood stem cells

This work is the first to validate gene expression analysis in human stem cells with functional experiments. The findings also suggest that changes in the expression of genes associated with universal cell signaling pathways can have a substantial impact on human stem cell behavior.

2 May 2005

Cancer survival comes at its own price

Patients who hear the dreaded words "you have cancer" invariably look forward to the day the doctor tells them "you're cured." But University of Florida researchers say survival often comes at its own price -- the mind may need mending even after the body heals.

16 Mar 2005

Blood clotting combo saves heart patients lives

Two studies presented Wednesday at the American College of Cardiology's annual scientific sessions in Orlando, Fla. have found that the clot-preventing drug Plavix when added to the treatment of people with severe heart attacks helps reopen their clogged arteries and saves lives.

9 Mar 2005

Studies find Aspirin resistance in up to 27% of Aspirin users

While aspirin remains a crucial and cost-effective therapy for the prevention and management of cardiovascular diseases, research suggests that a significant percentage of the 25 million Americans on a chronic aspirin regimen are "aspirin resistant," or do not achieve sufficient antiplatelet effects from aspirin.

7 Mar 2005

St. John's wort increases effectiveness of Plavix

The widely used herbal remedy St. John's wort appears to amplify the action of the popular blood-thinning drug clopidogrel, sold as Plavix, a small new clinical study finds.

6 Mar 2005

New bone marrow model could help people with sickle cell disease

A new model showing how sickle cell blood cells operate within bone marrow is presented at a conference in Austria today. Researchers at Imperial College London, who developed the model, hope that it will eventually be used by clinicians to advance more effective treatments for sickle cell disease.

20 Feb 2005

Blood tests improve within two weeks of quitting smoking

Long-term smokers who quit may benefit from almost immediate improvements in blood platelet function, which could potentially reduce their risk of heart attacks or strokes caused by blood clots, according to a new study in the Feb. 15, 2005 issue of the Journal of the American College of Cardiology.

16 Feb 2005

Clot-dissolving drugs such as tPA may help detect potentially deadly leg clots

A possible diagnostic use for clot-dissolving drugs such as tPA has been found by Medical College of Georgia researchers working to improve a test that identifies potentially deadly blood clots in the legs.

14 Feb 2005

Significant advance toward understanding lifelong process of blood cell formation

A research study published in the February issue of Developmental Cell expands on previous studies by using adult animals to examine the role of a key gene known to be required for blood cell formation. Information gained from this research will be useful for future studies aimed at directing stem cell differentiation in a variety of potential therapeutic contexts.

31 Jan 2005