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Scientists recreate rhinovirus infection in mice - hope of new asthma treatments

Scientists have been able to recreate rhinovirus infection, which is behind most common colds, in a small animal for the first time.

4 Feb 2008

Scientists identify protein's crucial role in resistance to breast cancer treatment

Scientists at the Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research in London have identified how some breast cancers may become resistant to hormone treatments like tamoxifen.

4 Feb 2008

Isocitric acid from fermentation of sunflower oil - a new building block for pharma?

The citric acid cycle, one of the most important metabolic processes in our bodies, was formulated in 1937. Since then, all of the intermediates have been produced in multigram quantities - with one exception, (2 R,3S)-isocitric acid.

4 Feb 2008

Neurogenesis plays an important role in the acquisition and storage of spatial memory

Boosted by physical and mental exercise, neural stem cells continue to sprout new neurons throughout life, but the exact function of these newcomers has been the topic of much debate.

4 Feb 2008

E.coli tweaked to produce hydrogen

For most people, the name "E. coli" is synonymous with food poisoning and product recalls, but a professor in Texas A&M University's chemical engineering department envisions the bacteria as a future source of energy, helping to power our cars, homes and more.

30 Jan 2008

Celebrex may disrupt heart rhythm

Celebrex, a popular arthritis drug that blocks pain by inhibiting an enzyme known as COX-2, has been shown in laboratory studies to induce arrhythmia, or irregular beating of the heart, via a novel pathway unrelated to its COX-2 inhibition.

25 Jan 2008

Synthesis of natural molecule could lead to better anti-cancer drugs

In early 2007, Northwestern University chemist Karl Scheidt's interest was piqued when marine chemist Amy Wright reported in the Journal of Natural Products that a new natural compound derived from an uncommon deep-sea sponge was extremely effective at inhibiting cancer cell growth.

24 Jan 2008

New method enables design, production of extremely novel drugs

A new chemical synthesis method based on a catalyst worth many times the price of gold and providing a far more efficient and economical method than traditional ones for designing and manufacturing extremely novel pharmaceutical compounds is described by its University at Buffalo developers in a review article in the current issue of Nature.

24 Jan 2008

DNA sensors found to be an effective artificial nose

In designing artificial noses modeled after biological olfaction, the challenge has been to generate a similarly large sensor repertoire with the requisite combinatorial complexity to detect odors in the real world.

24 Jan 2008

Cigarettes leave deadly path by purging protective genes

A University of Rochester scientist discovered that the toxins in cigarette smoke wipe out a gene that plays a vital role in protecting the body from the effects of premature aging.

24 Jan 2008

Brain molecule from endothelial cells may be a new target for treatment of multiple sclerosis

In the February issue of Nature Immunology, the team provides fresh answers concerning the role of novel adhesion molecules in the pathogenesis of MS, a chronic autoimmune disease of the nervous system that affects approximately 55,000 young adults in Canada.

23 Jan 2008

Genetic switches could lower cost of producing drugs, proteins

Bacteria have evolved complex mechanisms called quorum sensing systems that provide for cell-to-cell communication, an adaptation that allows them to wait until their population grows large enough before mounting an attack on a host or competing for nutrients.

23 Jan 2008

Stem cell research aims to tackle Parkinson's disease

Scientists in Sweden are developing new ways to grow brain cells in the laboratory that could one day be used to treat patients with Parkinson's disease, an international conference of biologists organised by the European Science Foundation (ESF) was told last week.

21 Jan 2008

Researchers identify a means of controlling a parasite that kills and eats human cells

Researchers from the University of Virginia and the University of Vermont have discovered a means of inhibiting one of the world's most voracious parasites.

21 Jan 2008

Smoking wipes out protective genes

A University of Rochester scientist discovered that the toxins in cigarette smoke wipe out a gene that plays a vital role in protecting the body from the effects of premature aging.

21 Jan 2008

Alzheimer's molecule is a smart speed bump on the nerve-cell transport highway

Researchers at the University of Pennsylvania School of Medicine discovered that proteins carrying chemical cargo in nerve cells react differently when exposed to the tau protein, which plays an important role in Alzheimer's disease.

18 Jan 2008

Smallest particles from vehicle emissions may promote hardening of the arteries

Patients prone to heart disease may one day be told by physicians to avoid not only fatty foods and smoking but air pollution too.

18 Jan 2008

Gold nanoparticles shine brightly in tumors

Solid gold nanoparticles have long been used to treat rheumatoid arthritis and more recently have shown promise in treating various types of cancer.

16 Jan 2008

New technique could dramatically lower costs of DNA sequencing

Using computer simulations, researchers at the University of Illinois have demonstrated a strategy for sequencing DNA by driving the molecule back and forth through a nanopore capacitor in a semiconductor chip.

16 Jan 2008

FDA extends review of Genasense NDA appeal in chronic lymphocytic leukemia

Genta Incorporated has announced that the Food and Drug Administration (FDA) has extended its review of Genta's appeal of the non- approvable decision for a New Drug Application (NDA) that proposed the use of Genasense (oblimersen sodium injection) plus chemotherapy in patients with relapsed or refractory chronic lymphocytic leukemia.

15 Jan 2008