Oncology News and Research

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Oncology, meaning bulk, mass, or tumor, and the suffix ''-logy'', meaning "study of") is a branch of medicine that deals with tumors (cancer). A medical professional who practices oncology is an ''oncologist''.

Laparoscopic proctectomy stands up to open surgery

Laparoscopic surgery produces comparable results to open surgery for rectal cancer, show the findings of the first, large, randomized trial of the technique.

14 Feb 2013

Out-of-hospital death does not equal less aggressive care

Rates of intensive care unit use in the last month of life among patients aged 65 years and older increased between 2000 and 2009 in the USA, despite a reduction in rates of in-hospital death, conflating the notion that there is a trend toward less aggressive care, say researchers.

14 Feb 2013

Study finds strong preference among families and older pediatric patients for IV feeding

About 60 percent of pediatric cancer patients experience malnourishment during treatment. At that point, patients and families have a choice: tube feeding or IV nutrition supplement. Which would you choose? A study published this week in the Journal of Pediatric Oncology Nursing shows that families' perceptions, especially of the discomfort of tube feeding, leads to choosing IV over tube - despite the fact that tube feeding is usually the better choice, associated with better gut function and lower rates of infection.

14 Feb 2013

Blocking C5a protein prevents low birth weight in babies born to pregnant women with malaria

An international team of tropical medicine researchers have discovered a potential method for preventing low birth weight in babies born to pregnant women who are exposed to malaria. Low birth weight is the leading cause of infant death globally.

14 Feb 2013

FDA grants orphan drug status to Lentigen’s LG631-CD34 for treatment of glioblastoma multiforme

Lentigen Corporation, a biotechnology company specializing in the development and manufacture of lentiviral gene delivery products, announced today that that the U.S. Food and Drug Administration (FDA) has granted orphan drug status to P140K methylguanine methyltransferase (MGMT) transduced human CD34 cells for bone marrow protection in the treatment of glioblastoma multiforme.

14 Feb 2013

Triple-negative breast cancers more biologically diverse than previously believed

Triple-negative breast cancers are more biologically diverse than previously believed and classification should be expanded to reflect this heterogeneity, according to University of North Carolina researchers.

14 Feb 2013

Ability to tune gene activity will permit refined research for drug resistance, cancer

Scientists who built a synthetic gene circuit that allowed for the precise tuning of a gene's expression in yeast have now refined this new research tool to work in human cells, according to research published online in Nature Communications.

13 Feb 2013

Tivozanib overall survival results announced by AVEO and Astellas

AVEO Oncology (NASDAQ: AVEO) and Astellas Pharma Inc. (TSE: 4503) announced overall survival (OS) for tivozanib, an investigational agent, from the Phase 3 TIVO-1 (TIvozanib Versus sOrafenib in 1st line advanced RCC) study in patients with advanced renal cell carcinoma (RCC). The final OS analysis, as specified by the protocol, shows a median OS of 28.8 months (95% confidence interval [CI]: 22.5–NA) for tivozanib versus a median OS of 29.3 months (95% CI: 29.3–NA) for the comparator arm, sorafenib.

13 Feb 2013

HRI to begin enrollment in RAD001 Phase II trial for Neurofibromatosis Type-2

House Research Institute (HRI) is recruiting patients for a Phase II clinical trial to test a medication that may slow the progression of Neurofibromatosis Type-2, commonly referred to as NF2.

13 Feb 2013

New drug delivery system can reduce size of ovarian tumors by as much as 83%

By loading fragile RNA into silicon nanoparticles, researchers from The Methodist Hospital and two other institutions found a new drug delivery system can reduce the size of ovarian tumors by as much as 83 percent -- and stop tumor growth in chemotherapy-resistant ovarian cancer tissue.

13 Feb 2013

Pac-fico Salud and Johns Hopkins sign landmark affiliation agreement

World-class standards for clinical outcomes and patient safety are at the core of a landmark affiliation agreement signed today between Johns Hopkins Medicine International (JHI) and Pac-fico S.A. Entidad Prestadora de Salud (Pac-fico Salud), a Lima, Peru-based subsidiary of Credicorp Ltd.

13 Feb 2013

RNAi effective in treating cancer patients

The new study published in Cancer Discovery, the flagship journal of the American Association of Cancer Research (AACR), involving three Spanish and six American research centres, presents significant results in treating cancer patients with nanoparticles containing ribonucleic acid interference (RNAi) molecules.

13 Feb 2013

Piroxicam ultrasound combination optimal for knee osteoarthritis

Phonophoresis of the non steroidal anti-inflammatory drug piroxicam with ultrasound is more effective than ultrasound alone for improving pain and other symptoms of mild-to-moderate knee osteoarthritis, show study findings.

12 Feb 2013

Low vitamin D not linked to poor physical performance in octogenarians

Researchers have found no evidence for a link between low vitamin D levels and impaired physical performance in people aged 80 years or older.

12 Feb 2013

Metastatic renal cell carcinoma (mRCC) therapy: an interview with Charles A. Nicolette, Ph.D., CSO of Argos Therapeutics

Metastatic renal cell carcinoma is a devastating disease. There are roughly 20-25,000 new cases per year in the United States and it is increasing for some reason.

12 Feb 2013

Researchers identify miR-506 as potential therapeutic candidate for metastatic ovarian cancer

Researchers employed an extensive analysis of genomic information to identify a new, high-risk cohort of ovarian cancer patients, characterize their tumors, find a potential treatment and test it in mouse models of the disease.

11 Feb 2013

Selumetinib shows high response rate for patients with low-grade serous ovarian cancer

Low-grade serous ovarian cancer is less common and aggressive than the high-grade variety, yet exceptionally difficult to treat when frontline therapy fails.

11 Feb 2013

MicroRNA can be used to define four subtypes of triple-negative breast cancer

A new, large-scale study of triple-negative breast cancer shows that small molecules called microRNA can be used to define four subtypes of this aggressive malignancy.

11 Feb 2013

Review describes long-term side-effects of molecularly targeted therapies in children with cancer

A University of Colorado Cancer Center review published this week in the journal Lancet Oncology describes possible long-term side-effects of new, targeted therapies in pediatric cancer patients: what we don't know may hurt us.

11 Feb 2013

SUVmax may help indicate progression-free survival in stage I NSCLC patients treated with SBRT

SUVmax (Maximum Standardized Uptake Value) may be a significant and clinically independent marker to indicate progression-free survival in stage I non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT), according to research being presented at the 2013 Cancer Imaging and Radiation Therapy Symposium.

10 Feb 2013

Oncology News and Research

Further Reading

Laparoscopic proctectomy stands up to open surgery

Out-of-hospital death does not equal less aggressive care

Study finds strong preference among families and older pediatric patients for IV feeding

Blocking C5a protein prevents low birth weight in babies born to pregnant women with malaria

FDA grants orphan drug status to Lentigen’s LG631-CD34 for treatment of glioblastoma multiforme

Triple-negative breast cancers more biologically diverse than previously believed

Ability to tune gene activity will permit refined research for drug resistance, cancer

Tivozanib overall survival results announced by AVEO and Astellas

HRI to begin enrollment in RAD001 Phase II trial for Neurofibromatosis Type-2

New drug delivery system can reduce size of ovarian tumors by as much as 83%

Pac-fico Salud and Johns Hopkins sign landmark affiliation agreement

RNAi effective in treating cancer patients

Piroxicam ultrasound combination optimal for knee osteoarthritis

Low vitamin D not linked to poor physical performance in octogenarians

Metastatic renal cell carcinoma (mRCC) therapy: an interview with Charles A. Nicolette, Ph.D., CSO of Argos Therapeutics

Researchers identify miR-506 as potential therapeutic candidate for metastatic ovarian cancer

Selumetinib shows high response rate for patients with low-grade serous ovarian cancer

MicroRNA can be used to define four subtypes of triple-negative breast cancer

Review describes long-term side-effects of molecularly targeted therapies in children with cancer

SUVmax may help indicate progression-free survival in stage I NSCLC patients treated with SBRT

eBook: Liquid biopsy in cancer research eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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