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A special issue on the emerging COVID-19 infection

Acta Pharmaceutica Sinica B publishes special issue on 'Research on Emerging COVID-19 (Target, Mechanism, and Therapeutics)' edited by Hai-Bin Luo, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Shilin Chen, Institute of Chinese Materia Medica, Beijing, China and Peiqing Liu, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

29 Sep 2020

ACD study underscores the prevalence of malnutrition among obese individuals

A new editorial accompanying a study published in the Journal of the American College of Cardiology is bringing attention to the underappreciated and often overlooked issue of malnutrition among those who are obese.

29 Sep 2020

Fasting blood glucose levels upon admission tied to COVID-19 prognosis, study finds

In the study, which appeared on the pre-print open-source medRxiv* server, the investigators aimed to determine the prognostic value of blood glucose in predicting outcomes in COVID-19 disease, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

28 Sep 2020

Smell and taste changes last longer than other COVID-19 symptoms

A preprint paper published on the medRxiv server details a recent study by researchers from The Hebrew University, Hadassah-Hebrew University medical center, and Hadassah University Hospital, which addresses this gap in knowledge about the symptoms experienced by COVID-19 patients.

28 Sep 2020

SARS-CoV-2 re-infection is real but rare: Case study

Now, American researchers have looked at all reported cases of re-infection and the possible reasons behind them. Their study titled, “Re-infection with SARS-CoV-2 and Failure of Humoral Immunity: a case report,” is published online on the preprint server medRxiv in September 2020.

28 Sep 2020

Healthy vitamin D levels could reduce COVID-19 complications

Published in the journal PLOS ONE, the study investigates the link between serum 25-hydroxyvitamin D levels and its effect on adverse clinical outcomes and parameters of immune function and mortality due to COVID-19.

28 Sep 2020

One-third of parents in the U.S. won’t get flu shots for their kids during the pandemic

A survey from the National Poll on Children’s Health, however, revealed that one-third of American parents have no plans of getting their children vaccinated for the flu virus this year during the COVID-19 pandemic.

28 Sep 2020

Study pinpoints heating element in vaping devices as cause for lung injuries

Early results of an experimental vaping study have shown significant lung injury from E-cigarette (eC) devices with nickel-chromium alloy heating elements.

28 Sep 2020

J&J's COVID-19 vaccine shows potent immune response in phase 2 human trial

A multicenter phase 1/2a randomized, double-blinded, placebo-controlled clinical trial has been conducted recently to evaluate the safety, reactogenicity, and immunogenicity of a non-replicating adenovirus-based vaccine, namely Ad26.COV2.S against severe acute respiratory coronavirus 2 (SARS-CoV-2) infection.

28 Sep 2020

Hamsters and ferrets clear low dose SARS-CoV-2 infection in 14 days

A recent study by French researchers has demonstrated that experimental exposure to severe acute respiratory coronavirus 2 (SARS-CoV-2) is capable of inducing mild infection in hamsters and ferrets within 7 – 10 days of exposure. However, the infection completely resolves within 14 days. The study is currently available on the bioRxiv preprint server.

28 Sep 2020

COVID-19 may deteriorate men's testosterone levels, new data suggests

For the first time, data from a study with patients hospitalized due to COVID-19 suggest that the disease might deteriorate men's testosterone levels.

28 Sep 2020

Researchers discover specific cellular pathway involved in lung tissue regeneration

Researchers at Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania have identified a cellular pathway that can be targeted with a naturally occurring drug to stimulate lung tissue regeneration, which is necessary for recovery from multiple lung injuries.

28 Sep 2020

Resveratrol and pterostilbene inhibit SARS-CoV-2 infection in vitro

A team of scientists at the University of Groningen, in the Netherlands, demonstrates that a natural plant product, resveratrol, and its structural analog, pterostilbene, have long-lasting antiviral effects against severe acute respiratory coronavirus 2 (SARS-CoV-2) infection. The study is currently available on the bioRxiv preprint server.

28 Sep 2020

Life-threatening COVID-19 associated with specific genetic variants

Results of a genome-wide association study on 2,244 critically-ill patients due to coronavirus disease (COVID-19) from 208 intensive care units across the United Kingdom revealed significant host-specific genetic determinants that can predispose people to the severe form of the disease. The report is currently available on the medRxiv preprint server.

28 Sep 2020

Mapping the evolutionary profile of SARS-CoV-2 and COVID-19 using mutation order approach

Several months into the COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we still do not know much about the early evolutionary history and order of mutational events of the virus during this pandemic.

28 Sep 2020

Genetic mutations hinder immune response in severe COVID-19

Now, a truly international team of nearly 140 researchers aimed to determine why some people develop severe illness when once infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease.

28 Sep 2020

Auto-antibodies may explain why some people develop severe COVID-19

Now, a new study by an international team of health experts shows that some life-threatening cases of COVID-19 can be traced to specific weak spots in the patients' immune system.

28 Sep 2020

Clover Biopharma's new trimeric subunit vaccine candidate prevents COVID-19 in monkeys

The vaccine candidate produced a high level of neutralizing antibodies in animal models. Rhesus macaques immunized with the vaccine candidate showed reduced viral loads in the lungs. The research is published on the preprint server bioRxiv.

28 Sep 2020

Special formulation of inhaled niclosamide may be effective against SARS-CoV-2

Now in new research published on the preprint server bioRxix*, a novel formulation of the drug Niclosamide (NIC) is observed to be effective against SARS-CoV-2 and MERS-CoV in mouse models; it also protects against methicillin-resistance Staphylococcus aureus pneumonia and inflammatory lung damage.

28 Sep 2020