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Drug used to treat breast and ovarian cancer can transform treatment for prostate cancer

A drug used to treat breast and ovarian cancer can extend the lives of some men with prostate cancer and should become a new standard treatment for the disease, concludes a major trial which is set to change clinical practice.

21 Sep 2020

In vitro testing suggests effective novel drug combinations for SARS-CoV-2

A recent study published on the preprint server bioRxiv* in September 2020 shows the value of drug combinations to enhance the therapeutic and preventive efficacy of such repositioned drugs in standard antiviral therapy.

20 Sep 2020

Scientists investigate active plasma metabolite of remdesivir in SARS-CoV-2 mouse model

Using mouse models, scientists have investigated the active plasma metabolite of remdesivir, GS-441 524, and hydroxychloroquine as possible drug candidates in COVID-19. The research shows GS-441 524 could be an effective therapeutic drug against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while at the same time discounting hydroxychloroquine as a reliable anti-viral.

20 Sep 2020

Lopinavir-ritonavir does not suppress SARS-CoV-2 activity in vitro

Among them is the combination of lopinavir and ritonavir, which have been in use in an attempt to reduce the severity of the disease. However, a new South Korean study published on the preprint server bioRxiv in September 2020 shows that this combination is ineffective against the virus.

20 Sep 2020

Novel sequencing method could be useful for COVID-19 research

Researchers at the University of Chicago and the Cleveland Clinic have presented a novel single-cell RNA sequencing method that could be a useful application for research into the current coronavirus disease 2019 (COVID-19) pandemic.

20 Sep 2020

New polygenic risk score to help predict the odds of drugs causing liver damage

The ancient Romans studied the livers of sacrificial animals to read omens and make prophesies. Now researchers at Tokyo Medical and Dental University and Takeda-CiRA program along with a world-wide team of collaborators, have devised a polygenic risk score (PRS) based on liver genomics that can predict the likelihood of medications causing liver damage.

19 Sep 2020

Trial shows new first-line treatment option for patients with metastatic kidney cancer

The results of the phase 3 CheckMate 9ER trial have provided a new first-line treatment option for patients with metastatic kidney cancer. The late breaking results are presented at ESMO 2020.

19 Sep 2020

Cory Gardner’s bill has as much to do with politics as preexisting conditions

Sen. Cory Gardner, a Republican running in a tight race for reelection in Colorado, says he wants to protect people with medical conditions.

18 Sep 2020

Researchers identify new path to defeating chronic myelogenous leukemia

Researchers have identified a second path to defeating chronic myelogenous leukemia, which tends to affect older adults, even in the face of resistance to existing drugs.

18 Sep 2020

Researchers develop non-infectious nanoparticle probes to study SARS-CoV-2

Scientists and researchers at the U.S. Naval Research Laboratory and National Center for Advancing Translational Sciences, submitted their findings to ACS Nano, a monthly peer-reviewed scientific journal, on their collaboration to develop SARS-CoV-2 nanoparticle probes that are used to study fundamental interactions between SARS-CoV-2 Spike proteins and human cells.

18 Sep 2020

New partnership aims to advance predictive tests for multiple myeloma in Ireland

By combining genomic testing and next generation sequencing technology, a new partnership led by RCSI researchers aims to advance predictive tests for multiple myeloma, the second most common blood cancer in Ireland.

18 Sep 2020

Key China COVID-19 study produced results that influenced subsequent research on coronavirus

Early in the onset of the COVID-19 pandemic, a small study in China produced results that influenced subsequent research on the virus.

18 Sep 2020

Study highlights need for scientific, pharmaceutical standards for developing live biotherapeutic products

The Pharmabiotic Research Institute (PRI), Europe's only regulatory expertise centre for the development of microbiome-based drug products, has announced the publication of a review titled "Live biotherapeutic products: the importance of a defined regulatory framework".

18 Sep 2020

Researchers identify biomarkers that predict patient’s response to metformin treatment

Metformin is the first-line drug that can lower blood sugar levels in type 2 diabetes patients. One third of patients do not respond to metformin treatment and 5 per cent experience serious side effects, which is the reason many choose to stop medicating.

18 Sep 2020

Cellular recyclers could be used to eliminate the driver of cancer's aggressiveness

"Do not erase." "Recycle me." "Free to a good home." Humans post these signs to indicate whether something has value or not, whether it should be disposed of or not.

18 Sep 2020

Study shows huge asymmetry in cancer clinical trials in different countries

Access to cancer medicines is highly unequal across Europe both for new drugs in development because of uneven access to clinical trials and for currently approved drugs due to huge disparities in healthcare spending by different countries, according to results from studies presented at ESMO 2020.

18 Sep 2020

Scientists investigate how psychedelic drugs interact with brain cells at the molecular level

Psychedelic drugs such as LSD, psilocybin, and mescaline cause severe and often long-lasting hallucinations, but they show great potential in treating serious psychiatric conditions, such as major depressive disorder.

18 Sep 2020

Engineered, high-affinity ACE2 receptors neutralize SARS-CoV-2

In a study published in the preprint server bioRxiv, researchers from the Kyoto Prefectural University of Medicine and Osaka University Japan, discuss how they engineered ACE2 to enhance its affinity to RBD in human cells.

17 Sep 2020

Animal data supports efficacy of baricitinib vs SARS-COV-2

The high burden of disease caused by the COVID-19 pandemic has led to much research on effective ways to mitigate the health, social, and economic impact of the spread of the infection. A recent study published on the preprint server bioRxiv* in September 2020 reports on the characteristics of the drug baricitinib when used as monotherapy to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Sep 2020

MDI Biological Laboratory receives €280,000 to address the problem of tendon injury

Modern medicine has made tremendous strides in replacing organs and hips. But what about those all-important tendons, which enable joint movement by connecting muscle to bone? Tendon injuries, such as those in the knee, elbow, Achilles tendon and rotator cuff (shoulder) exact a huge cost in terms of health care, productivity and quality of life.

17 Sep 2020

Drugs News and Research

Drug used to treat breast and ovarian cancer can transform treatment for prostate cancer

In vitro testing suggests effective novel drug combinations for SARS-CoV-2

Scientists investigate active plasma metabolite of remdesivir in SARS-CoV-2 mouse model

Lopinavir-ritonavir does not suppress SARS-CoV-2 activity in vitro

Novel sequencing method could be useful for COVID-19 research

New polygenic risk score to help predict the odds of drugs causing liver damage

Trial shows new first-line treatment option for patients with metastatic kidney cancer

Cory Gardner’s bill has as much to do with politics as preexisting conditions

Researchers identify new path to defeating chronic myelogenous leukemia

Researchers develop non-infectious nanoparticle probes to study SARS-CoV-2

New partnership aims to advance predictive tests for multiple myeloma in Ireland

Key China COVID-19 study produced results that influenced subsequent research on coronavirus

Study highlights need for scientific, pharmaceutical standards for developing live biotherapeutic products

Researchers identify biomarkers that predict patient’s response to metformin treatment

Cellular recyclers could be used to eliminate the driver of cancer's aggressiveness

Study shows huge asymmetry in cancer clinical trials in different countries

Scientists investigate how psychedelic drugs interact with brain cells at the molecular level

Engineered, high-affinity ACE2 receptors neutralize SARS-CoV-2

Animal data supports efficacy of baricitinib vs SARS-COV-2

MDI Biological Laboratory receives €280,000 to address the problem of tendon injury

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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