Clinical Trial News and Research

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FDA grants Orphan Drug Designation to Alnylam ALN-AT3 for treatment of hemophilia B

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced today that the U.S. Food & Drug Administration (FDA) has granted an Orphan Drug Designation to ALN-AT3 as a therapeutic for the treatment of hemophilia B.

17 Aug 2013

Older heart patients present unique challenges for determining optimal dosages of medications

Older heart patients present unique challenges for determining the optimal dosages of medications, so a new study from researchers at Duke Medicine offers some rare clarity about the use of drugs that are used to treat patients with heart attacks.

17 Aug 2013

Calcium and vitamin D supplements have no effect on joint symptoms in postmenopausal women

A team of investigators systematically analyzed the effect of calcium and vitamin D supplementation on joint symptoms in a rigorous and controlled study of postmenopausal women. They found that supplementation did not reduce the severity of joint symptoms reported by the participants.

17 Aug 2013

DLBCLs resistant to chemotherapy can be reprogrammed to respond using azacitidine

A phase I clinical trial showed diffuse, large B-cell lymphomas (DLBCLs) resistant to chemotherapy can be reprogrammed to respond to treatment using the drug azacitidine, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

17 Aug 2013

BIDMC cardiovascular research team receives $4M grant to identify mRNA biomarkers in heart disease

A cardiovascular research team from Beth Israel Deaconess Medical Center (BIDMC) and Brigham and Women's Hospital (BWH), led by BIDMC Principal Investigator Saumya Das, MD, PhD, has been awarded a $4 million Common Fund grant from the National Institutes of Health (NIH) as part of a newly formed program on Extracellular RNA Communication.

17 Aug 2013

New remote monitoring platform fulfills FDA's guidance on remote, central and risk-based monitoring

The ROMaN Project, Inc. announces its endorsement of the Food and Drug Administration's (FDA) guidance to utilize risk-based monitoring in clinical trials. Risk-based monitoring focuses attention to the most critical data elements in a study and allocates monitoring resources to the investigator sites with problematic or unproven protocol compliance and/or data integrity.

16 Aug 2013

Phase II trial to investigate vaccine therapy combined with Avastin for patients with recurrent GBM

Northwestern Medicine- recently joined a landmark clinical trial to investigate if a vaccine made from a patient's own brain tumor is effective in slowing tumor progression and extending survival.

16 Aug 2013

Surgeons evaluate combined surgery technique to remove cancerous tumors from rectum

Surgeons at the University of California, San Diego School of Medicine are evaluating a new, combined surgery technique to remove cancerous tumors from the rectum. The hybrid technique uses the body's natural opening to remove malignancies and diseased tissue while also performing reconstruction.

16 Aug 2013

Six months of intravenous fish oil reverses pediatric intestinal failure associated liver disease

Children who suffer from intestinal failure, most often caused by a shortened or dysfunctional bowel, are unable to consume food orally. Instead, a nutritional cocktail of sugar, protein and fat made from soybean oil is injected through a small tube in their vein.

16 Aug 2013

Joint symptoms in postmenopausal women not reduced by calcium and vitamin D supplements

A team of investigators systematically analyzed the effect of calcium and vitamin D supplementation on joint symptoms in a rigorous and controlled study of postmenopausal women.

16 Aug 2013

Sugar offers noninvasive way to precisely image tumors through new imaging technology

A natural form of sugar could offer a new, noninvasive way to precisely image tumors and potentially see whether cancer medication is effective, by means of a new imaging technology developed at UC San Francisco in collaboration with GE Healthcare.

16 Aug 2013

Hitting treadmill today won't help you sleep tonight; it takes 4 months to kick in

Exercise is a common prescription for insomnia. But spending 45 minutes on the treadmill one day won't translate into better sleep that night, according to new Northwestern Medicine- research.

16 Aug 2013

Neuroimaging specialists use tanners to identify whether UV light triggers brain's pleasure sensors

Neuroimaging specialists at UT Southwestern Medical Center are launching the first clinical trial involving frequent and infrequent tanners designed to identify whether UV light triggers the brain's pleasure sensors.

13 Aug 2013

Preclinical study reveals pomalidomide shows promising results for treatment of CNS lymphoma

A drug recently approved for use in multiple myeloma is now being tested for its ability to fight central nervous system (CNS) lymphoma, a deadly cancer of the immune system that can affect the brain, spinal cord and fluid, and eyes.

13 Aug 2013

Vitamin D supplementation does not improve blood pressure in hypertension patients

Vitamin D supplementation does not appear to improve blood pressure or markers of vascular health in older patients with isolated systolic hypertension (a common type of high blood pressure), according to a study by Miles D. Witham, Ph.D., of the University of Dundee, Scotland, United Kingdom, and colleagues.

13 Aug 2013

Cedars-Sinai launches Phase I clinical trial to study tolerability of immunization to treat Alzheimer's disease

Cedars-Sinai Medical Center has launched a Phase I clinical trial to study the safety and tolerability of an experimental immunization to treat Alzheimer's disease. The treatment is based on Copaxone (glatiramer acetate), a drug often prescribed to reduce the frequency of multiple sclerosis relapses.

13 Aug 2013

Omeros announces financial results for second quarter of 2013

Omeros Corporation, a clinical-stage biopharmaceutical company committed to discovering, developing and commercializing products targeting inflammation, coagulopathies and disorders of the central nervous system, today announced its financial results for the second quarter of 2013.

12 Aug 2013

NW Bio receives decision to continue Phase III clinical trial on brain cancer in Germany

Northwest Biotherapeutics (NASDAQ: NWBO)(NW Bio), a biotechnology company developing non-toxic DCVax® personalized immune therapies for solid tumor cancers, announced today that it has received a decision from the German regulatory agency (the Paul Ehrlich Institute, or PEI) under which the Company's Phase III clinical trial will be able to proceed in Germany after the Company makes three modifications, none of which affect the body of the trial or the bases for seeking product approval.

12 Aug 2013

Complex and messy ethical, social and cultural issues often left on table

Resolving complex ethical, social and cultural issues in the early stage of a global health research project or clinical trial can improve the impact and quality of that research, a new report says.

12 Aug 2013

Gene combination therapy repairs and prevents future damage of muscles caused by DMD

New research on two promising gene therapies suggests that combining them into one treatment not only repairs muscle damage caused by Duchenne muscular dystrophy, but also prevents future injury from the muscle-wasting disease.

12 Aug 2013

Clinical Trial News and Research

FDA grants Orphan Drug Designation to Alnylam ALN-AT3 for treatment of hemophilia B

Older heart patients present unique challenges for determining optimal dosages of medications

Calcium and vitamin D supplements have no effect on joint symptoms in postmenopausal women

DLBCLs resistant to chemotherapy can be reprogrammed to respond using azacitidine

BIDMC cardiovascular research team receives $4M grant to identify mRNA biomarkers in heart disease

New remote monitoring platform fulfills FDA's guidance on remote, central and risk-based monitoring

Phase II trial to investigate vaccine therapy combined with Avastin for patients with recurrent GBM

Surgeons evaluate combined surgery technique to remove cancerous tumors from rectum

Six months of intravenous fish oil reverses pediatric intestinal failure associated liver disease

Joint symptoms in postmenopausal women not reduced by calcium and vitamin D supplements

Sugar offers noninvasive way to precisely image tumors through new imaging technology

Hitting treadmill today won't help you sleep tonight; it takes 4 months to kick in

Neuroimaging specialists use tanners to identify whether UV light triggers brain's pleasure sensors

Preclinical study reveals pomalidomide shows promising results for treatment of CNS lymphoma

Vitamin D supplementation does not improve blood pressure in hypertension patients

Cedars-Sinai launches Phase I clinical trial to study tolerability of immunization to treat Alzheimer's disease

Omeros announces financial results for second quarter of 2013

NW Bio receives decision to continue Phase III clinical trial on brain cancer in Germany

Complex and messy ethical, social and cultural issues often left on table

Gene combination therapy repairs and prevents future damage of muscles caused by DMD

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