Clinical Trial News and Research

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Radionuclide drug treatment planning goes to next level with 3-D patient models

External beam radiation treatment has long been manipulated into the unique shape of patients' tumors for personalized cancer care. Technology providing a means of patient-specific radionuclide drug therapies has not been standardized, as it has been limited to software that requires oncologists to manually define the areas of tumors.

13 Jun 2013

Eribulin shows increased benefit among women sharing certain traits

Subgroup analyses from a phase III clinical trial comparing a newer chemotherapy agent called eribulin mesylate, with capecitabine, a standard chemotherapy medication in women with previously treated metastatic breast cancer, showed increased benefit among women sharing certain traits.

13 Jun 2013

NeuroVive signs agreement with Isomerase Therapeutics to develop and commercialize cyclophilin-inhibiting molecules

NeuroVive Pharmaceutical AB (publ) (STO:NVP), a leading mitochondrial medicine company, has signed a collaboration agreement with Isomerase Therapeutics to develop the molecules that were recently acquired from Biotica.

12 Jun 2013

Researchers to launch Phase II clinical trial to investigate potential new therapy for sickle cell anemia

Seeking to improve the lives of sickle cell anemia sufferers around the world, researchers from the La Jolla Institute for Allergy and Immunology, the Dana-Farber/Children's Hospital Cancer Center in Boston and the BloodCenter of Wisconsin in Milwaukee and others are preparing to launch Phase II of a clinical trial to investigate a potential new therapy for reducing the disorder's severest symptoms.

12 Jun 2013

Mayo Clinic announces first US stem cell clinical trial for children with hypoplastic left heart syndrome

Mayo Clinic has announced the first U.S. stem cell clinical trial for pediatric congenital heart disease. The trial aims to determine how stem cells from autologous umbilical cord blood can help children with hypoplastic left heart syndrome, a rare defect in which the left side of the heart is critically underdeveloped.

12 Jun 2013

Massachusetts Eye and Ear enrolls deaf children in new clinical trial of Auditory Brainstem Implant

The Massachusetts Eye and Ear Infirmary, a Harvard Medical School teaching affiliate, is now enrolling a select group of deaf infants and children in a new FDA-approved clinical trial of an Auditory Brainstem Implant.

12 Jun 2013

Countrywide study in Germany deems PRRT as life-prolonging treatment for patients with NETs

Peptide-receptor radionuclide therapy has been a subject of growing research on neuroendocrine tumors, which take up residence in a variety of organs replete with nerve cells that respond to hormone signaling.

12 Jun 2013

Understanding Phelan-McDermid Syndrome

In the first prospective study of its kind, Seaver Autism Center researchers at the Icahn School of Medicine at Mount Sinai provide new evidence of the severity of intellectual, motor, and speech impairments in a subtype of autism called Phelan-McDermid Syndrome.

12 Jun 2013

Studies demonstrate that combined therapy could destroy drug-resistant cells within melanoma tumor

Advanced metastatic melanoma is a disease that has proven difficult to eradicate. Despite the success of melanoma-targeting drugs, tumors inevitably become drug resistant and return, more aggressive than before. In the current issue of the journal Cancer Cell, however, researchers at The Wistar Institute describe how they increase the effectiveness of anti-melanoma drugs by combining anticancer therapies with diabetes drugs.

12 Jun 2013

Clinical trial underway for potential new treatment for type 1 diabetes

A clinical trial is underway for a potential new treatment for type 1 diabetes that could eventually mean patients are able to reduce insulin treatment from several times a day to only once or twice a week. The new treatment is a direct result of research to understand the genetics of the disease.

11 Jun 2013

Cerus enrolls patient in two European clinical trials for INTERCEPT System for RBCs

Cerus Corporation announced today that it has initiated patient enrollment in two European Phase III clinical trials for the INTERCEPT System for red blood cells.

11 Jun 2013

Abbott starts ABSORB Japan trial to evaluate Absorb BVS in patients with CAD

Abbott today announced that it has initiated the ABSORB Japan randomized controlled clinical trial to evaluate the Absorb Bioresorbable Vascular Scaffold in patients with coronary artery disease, the most common form of heart disease.

11 Jun 2013

Medicago gets Health Canada clearance to initiate Phase II clinical trial for H5N1 vaccine

Medicago Inc., a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles, today announced it has received clearance by Health Canada to initiate its Phase II dose-sparing clinical trial for an H5N1 Avian Influenza VLP vaccine candidate ("H5N1 vaccine").

11 Jun 2013

Combination of cell-killing radioactive particle and antibody is safe for treating cancers

An experimental treatment that combines a cell-killing radioactive particle with an antibody that homes in on cancer cells is safe in the treatment of cancers spreading through patients' abdomens, according to data from a first-in-human study presented today at the Society of Nuclear Medicine and Molecular Imaging annual meeting in Vancouver.

11 Jun 2013

Rapamycin improves cardiac function in mice suffering from age-related heart disease

Elderly mice suffering from age-related heart disease saw a significant improvement in cardiac function after being treated with the FDA-approved drug rapamycin for just three months.

11 Jun 2013

Using stress CMR imaging for patients with acute chest pain is a win-win situation, say doctors

Wake Forest Baptist Medical Center doctors have found that using stress cardiac magnetic resonance (CMR) imaging in an Emergency Department observation unit to care for patients with acute chest pain is a win-win - for the patient and the institution.

11 Jun 2013

International clinical study shows that BioProtect Balloon Implant has potential to reduce rectal injury

Several years ago, Virginia Commonwealth University Massey Cancer Center became the first center in the United States to test an Israeli-invented device designed to increase the space between the prostate and the rectum in prostate cancer patients undergoing radiation therapy.

11 Jun 2013

Concert Pharmaceuticals announces initiation of CTP-354 Phase 1 trial in healthy volunteers

Concert Pharmaceuticals, Inc. today announced that it has initiated a Phase 1 clinical trial with CTP-354. CTP-354 is a novel GABAA receptor subtype-selective modulator that has demonstrated no sedation at therapeutic doses in preclinical models in contrast to existing GABAA receptor non-selective agonists, such as benzodiazepines.

10 Jun 2013

Exact Sciences announces submission of final module of PMA application to FDA for Cologuard

Exact Sciences Corp. today announced that it has submitted to the U.S. Food and Drug Administration the final module of the premarket approval application for Cologuard, the company's stool DNA (sDNA) colorectal cancer screening test.

10 Jun 2013

Drug used to control Type II diabetes can help repair spinal cords of mice suffering from inherited disease

A drug used to control Type II diabetes can help repair the spinal cords of mice suffering from the inherited disease adrenoleukodystrophy which, untreated, leads eventually to a paralysis, a vegetative state and death.

10 Jun 2013

Clinical Trial News and Research

Radionuclide drug treatment planning goes to next level with 3-D patient models

Eribulin shows increased benefit among women sharing certain traits

NeuroVive signs agreement with Isomerase Therapeutics to develop and commercialize cyclophilin-inhibiting molecules

Researchers to launch Phase II clinical trial to investigate potential new therapy for sickle cell anemia

Mayo Clinic announces first US stem cell clinical trial for children with hypoplastic left heart syndrome

Massachusetts Eye and Ear enrolls deaf children in new clinical trial of Auditory Brainstem Implant

Countrywide study in Germany deems PRRT as life-prolonging treatment for patients with NETs

Understanding Phelan-McDermid Syndrome

Studies demonstrate that combined therapy could destroy drug-resistant cells within melanoma tumor

Clinical trial underway for potential new treatment for type 1 diabetes

Cerus enrolls patient in two European clinical trials for INTERCEPT System for RBCs

Abbott starts ABSORB Japan trial to evaluate Absorb BVS in patients with CAD

Medicago gets Health Canada clearance to initiate Phase II clinical trial for H5N1 vaccine

Combination of cell-killing radioactive particle and antibody is safe for treating cancers

Rapamycin improves cardiac function in mice suffering from age-related heart disease

Using stress CMR imaging for patients with acute chest pain is a win-win situation, say doctors

International clinical study shows that BioProtect Balloon Implant has potential to reduce rectal injury

Concert Pharmaceuticals announces initiation of CTP-354 Phase 1 trial in healthy volunteers

Exact Sciences announces submission of final module of PMA application to FDA for Cologuard

Drug used to control Type II diabetes can help repair spinal cords of mice suffering from inherited disease

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