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Adding abemaciclib to hormonal therapy reduces recurrence in patients with HR+ HER2- early breast cancer

Adding abemaciclib to hormonal therapy reduces the risk of cancer recurrence by 25% in patients with high-risk early hormone receptor positive (HR+) human epidermal growth factor receptor 2 negative (HER2-) breast cancer, according to results from a study at ESMO 2020.

21 Sep 2020

Drug used to treat breast and ovarian cancer can transform treatment for prostate cancer

A drug used to treat breast and ovarian cancer can extend the lives of some men with prostate cancer and should become a new standard treatment for the disease, concludes a major trial which is set to change clinical practice.

21 Sep 2020

Study identifies new regions of positive selection in SARS-CoV-2

Based on structural modeling of ribonucleic acid (RNA) and proteins, the researchers from Duke University argue that newly identified regions of positive selection in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) likely affect species-specific RNA instead of protein function – improving our understanding of the molecular mechanisms responsible for highly unique biological properties of this virus.

20 Sep 2020

New polygenic risk score to help predict the odds of drugs causing liver damage

The ancient Romans studied the livers of sacrificial animals to read omens and make prophesies. Now researchers at Tokyo Medical and Dental University and Takeda-CiRA program along with a world-wide team of collaborators, have devised a polygenic risk score (PRS) based on liver genomics that can predict the likelihood of medications causing liver damage.

19 Sep 2020

Gene therapy used to overcome the cardiac effects of Freidreich’s ataxia

Gene therapy was successfully used to overcome the cardiac effects of Freidreich’s ataxia (FA) in a mouse model of the disease, as reported in the peer-reviewed journal Human Gene Therapy. Click here to read the full-text article free online through October 18, 2020.

19 Sep 2020

$Using AI and fractal dimension to accurately monitor ataxia$

Using AI and fractal dimension to accurately monitor ataxia

Exploiting artificial intelligence (AI) to develop tools for improving the monitoring of treatment of rare, progressive, and highly debilitating diseases such as Friedreich's (FRDA) and spinocerebellar ataxia (SCA).

19 Sep 2020

New insights into human genetics

Who are we? Where did we come from? How did we get here? Throughout the ages, humans have sought answers to these questions, pursuing wisdom through religion, philosophy, and eventually science.

19 Sep 2020

Cannabinoids cause changes in the brain that leads to deficiencies in social interaction

The nervous system comprises neurons and glial cells (glia signifies "glue"). Astrocytes are the most abundant among the glial cells.

19 Sep 2020

Genetic variants of human ACE2 are differentially recognized by SARS-CoV-2

Scientists at the University of Wisconsin reveals that the genetic variants of human angiotensin 2 (ACE2) receptors can have altered recognition by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic. The study is currently available on the bioRxiv* preprint server.

18 Sep 2020

New partnership aims to advance predictive tests for multiple myeloma in Ireland

By combining genomic testing and next generation sequencing technology, a new partnership led by RCSI researchers aims to advance predictive tests for multiple myeloma, the second most common blood cancer in Ireland.

18 Sep 2020

S-pseudotyped VLPs offer promising COVID-19 vaccine platform

A new study published on the preprint server bioRxiv* in September 2020 reports on a Moloney murine leukemia virus (MLV) platform that produces VLPs expressing the important spike antigen of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

18 Sep 2020

Study: 90-minute COVID-19 test has high sensitivity and specificity

A 90-minute COVID-19 test has been shown to have over 94 per cent sensitivity, and 100 per cent specificity in a new study.

18 Sep 2020

Strong causative link between smoking and bleeding in the brain

A decade ago, in a Nordic Twin Cohort study involving 79,664 twins from Denmark, Finland, and Sweden, researchers looked at risk factors of SAH other than genes.

17 Sep 2020

New methods help to accurately identify cancers’ hidden genetic losses, duplications

Understanding the specific mutations that contribute to different forms of cancer is critical to improving diagnosis and treatment.

17 Sep 2020

CNIC researchers uncover a mechanism explaining how macrophages regulate obesity

Macrophages are immune system cells. They are essential in the early response to infections, and they also have a key role in the proper functioning of our tissues and the regulation of obesity.

17 Sep 2020

Researchers secure NIH funding to study differences in glioblastoma between males and females

A team led by researchers from Case Western Reserve University School of Medicine and Cleveland Clinic Lerner Research Institute has secured $10.4 million over five years from the National Institutes of Health/National Cancer Institute to explore at the molecular level the differences in glioblastoma between males and females.

17 Sep 2020

Time-restricted feeding does not influence the muscle’s core clock, study finds

For the first time, scientists have studied the early effects of time-restricted feeding on the daily periodic oscillations of metabolites and genes in muscle, and metabolites in blood.

17 Sep 2020

Scientists identify new genetic cause of syndromic microcephaly

Greenwood Genetic Center researchers, in collaboration with scientists from Belgium, Spain, and Italy, have confirmed that variants in LMNB1 cause syndromic microcephaly with variable short stature, intellectual disability, and other neurological symptoms.

17 Sep 2020

Study provides new insight into the evolution of limb regeneration in lungfish and other species

For most vertebrates, losing a limb is permanent, but a lucky few species -- such as salamanders and tadpoles -- have the ability to completely regrow complex body parts.

17 Sep 2020

Study implicates new gene as driver of motor neuron diseases

Failures in a quality control system that protects protein-building fidelity in cells can lead to motor neuron degeneration and related diseases, according to a new study from an international team co-directed by Scripps Research molecular biologist Claudio Joazeiro, PhD.

16 Sep 2020

Genetic News and Research

Adding abemaciclib to hormonal therapy reduces recurrence in patients with HR+ HER2- early breast cancer

Drug used to treat breast and ovarian cancer can transform treatment for prostate cancer

Study identifies new regions of positive selection in SARS-CoV-2

New polygenic risk score to help predict the odds of drugs causing liver damage

Gene therapy used to overcome the cardiac effects of Freidreich’s ataxia

Using AI and fractal dimension to accurately monitor ataxia

New insights into human genetics

Cannabinoids cause changes in the brain that leads to deficiencies in social interaction

Genetic variants of human ACE2 are differentially recognized by SARS-CoV-2

New partnership aims to advance predictive tests for multiple myeloma in Ireland

S-pseudotyped VLPs offer promising COVID-19 vaccine platform

Study: 90-minute COVID-19 test has high sensitivity and specificity

Strong causative link between smoking and bleeding in the brain

New methods help to accurately identify cancers’ hidden genetic losses, duplications

CNIC researchers uncover a mechanism explaining how macrophages regulate obesity

Researchers secure NIH funding to study differences in glioblastoma between males and females

Time-restricted feeding does not influence the muscle’s core clock, study finds

Scientists identify new genetic cause of syndromic microcephaly

Study provides new insight into the evolution of limb regeneration in lungfish and other species

Study implicates new gene as driver of motor neuron diseases

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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