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Scientists identify natural SARS-CoV-2 super immunity against 23 variants

The antibodies are capable of neutralizing a wide range of SARS-CoV-2 variants even at sub-nanomolar concentrations. In addition, the combinations of these antibodies reduce the risk of generating escape mutants in vitro. The study is published in the journal Science.

5 Jul 2021

Novavax COVID-19 vaccine demonstrates ~90% efficacy against SARS-CoV-2

The findings reveal that the two-dose regimen of the vaccine is almost 90% effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Moreover, the vaccine shows high efficacy against the B.1.1.7 variant (Alpha) of SARS-CoV-2.

5 Jul 2021

Rapid quantification of SARS-CoV-2 Spike-specific T cells by direct peptide stimulation of whole peripheral blood

To understand both the correlates of protection induced by vaccinations and the necessary immune responses to manage the COVID-19, researchers from Singapore used an alternative method to closely evaluate the kinetics and magnitude of specific T cell responses to SARS-CoV-2 infection. Their work was posted to the bioRxiv* preprint server while awaiting peer review.

5 Jul 2021

Researchers develop random priming amplification method for whole-genome sequencing of SARS-CoV-2 and H1N1

Researchers from the UK recently compared the performance of 4 different random priming amplification methods to recover SARS-CoV-2 RNA. In method 1 (H-P), the reverse transcriptase (RT) step included random hexamers, whereas, in methods 2-4, RT incorporated an octamer primer with a known tag. This study is published on the bioRxiv preprint server.

5 Jul 2021

Janssens’ COVID-19 vaccine effective against SARS-CoV-2 Delta variant

Researchers in the Netherlands have conducted a study showing that Janssen’s Ad26.COV2.S coronavirus disease 2019 (COVID‐19) vaccine was effective against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among eight individuals.

4 Jul 2021

COVID-19 vaccination induces highly variable immunity among the immunocompromised

Researchers in the United States have conducted a study showing that the humoral (antibody) immunity induced by vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – varies significantly among immunocompromised individuals.

4 Jul 2021

Researchers reveal underlying genetic pathway behind neurological dysfunction of Rett syndrome

Medical researchers led by Kyushu University have revealed a possible underlying genetic pathway behind the neurological dysfunction of Rett syndrome.

2 Jul 2021

Structure-guided T cell vaccine design could offer broad protection SARS-CoV-2 variants

Gaurav Gaiha, MD, DPhil, a member of the Ragon Institute of MGH, MIT and Harvard, studies HIV, one of the fastest-mutating viruses known to humankind.

2 Jul 2021

NYU Abu Dhabi researchers use NMR spectroscopy to map the structure of specific nanobody

For the first time in the UAE, researchers at NYU Abu Dhabi have used nuclear magnetic resonance techniques to determine the structure of a specific nanobody, Nb23, potentially leading to a better understanding of how this small protein derived from an antibody type, found only in camelids (i.e camels, llamas, and alpacas) and sharks, can fight diseases ranging from rheumatoid arthritis, lupus and psoriasis to lymphoma and breast cancer.

2 Jul 2021

RNA-binding proteins represent a new class of drug targets for triple-negative breast cancer

In cancer research, it's a common goal to find something about cancer cells -- some sort of molecule -- that drives their ability to survive, and determine if that molecule could be inhibited with a drug, halting tumor growth. Even better: The molecule isn't present in healthy cells, so they remain untouched by the new therapy.

2 Jul 2021

Research pinpoints a molecular component responsible for modulating flu damage

New experimental data pinpoints a molecular component responsible for modulating the damage the flu can wreck on the lungs.

2 Jul 2021

UB scientists publish a detailed guide for producing mature human cells in a mouse embryo

A year after University at Buffalo scientists demonstrated that it was possible to produce millions of mature human cells in a mouse embryo, they have published a detailed description of the method so that other laboratories can do it, too.

2 Jul 2021

Salivary markers of oxidative stress during severe COVID-19

An interesting study from researchers at the University of Sharjah, Sharjah, United Arab Emirates, presents evidence that an elevated level of expression of oxidant molecules may be correlated with severe infection and lung injury.

2 Jul 2021

The use of flavonoids as antiviral agents against SARS-CoV-2

Researchers in Iran have undertaken a comprehensive review of flavonoids and their antiviral potential against SARS-CoV-2.

2 Jul 2021

Replication of SARS-CoV-2 in nasal ciliated cells could provide a new vaccination target

Researchers have found that nasal ciliated cells are targeted at the onset of COVID-19 infection, which may help to establish nasal mucosal immunity.

2 Jul 2021

Genetic variants in a neuro-associated gene cause neurodevelopmental disorder, finds study

Mayo Clinic researchers have discovered that genetic variants in a neuro-associated gene called SPTBN1 are responsible for causing a neurodevelopmental disorder. The study, published in Nature Genetics, is a first step in finding a potential therapeutic strategy for this disorder, and it increases the number of genes known to be associated with conditions that affect how the brain functions.

2 Jul 2021

Immunity to SARS-CoV-2 could last longer than originally believed

One year after infection by SARS-CoV-2, most people maintain anti-Spike antibodies regardless of the severity of their symptoms, according to a study with healthcare workers co-led by the Barcelona Institute for Global Health (ISGlobal), the Catalan Health Institute (ICS) and the Jordi Gol Institute (IDIAP JG), with the collaboration of the Daniel Bravo Andreu Private Foundation.

2 Jul 2021

Researchers reveal a promising target for designing anti-cancer therapies

Chances are, every one of us has been affected by cancer in one way or another. Unlike some other deadly diseases, cancer can take many forms inside the human body, so learning more about a single enzyme linked to many types of this disease could lead to more effective treatments.

2 Jul 2021

Research associates prior encounter with seasonal coronavirus to milder COVID-19 symptoms

A study by Stanford University School of Medicine investigators hints that people with COVID-19 may experience milder symptoms if certain cells of their immune systems "remember" previous encounters with seasonal coronaviruses -- the ones that cause about a quarter of the common colds kids get.

2 Jul 2021

Engineered T cells prevent translational shutdown in SARS-CoV-2 infected cells

In a paper recently uploaded to the preprint server bioRxiv* by Schamel et al. (June 25th, 2021) engineered T cells against SARS-CoV-2 are tested against a range of cells in vitro, finding that the treatment could be used to restore cellular immune function and suppress SARS-CoV-2.

1 Jul 2021

Protein C News and Research

Scientists identify natural SARS-CoV-2 super immunity against 23 variants

Novavax COVID-19 vaccine demonstrates ~90% efficacy against SARS-CoV-2

Rapid quantification of SARS-CoV-2 Spike-specific T cells by direct peptide stimulation of whole peripheral blood

Researchers develop random priming amplification method for whole-genome sequencing of SARS-CoV-2 and H1N1

Janssens’ COVID-19 vaccine effective against SARS-CoV-2 Delta variant

COVID-19 vaccination induces highly variable immunity among the immunocompromised

Researchers reveal underlying genetic pathway behind neurological dysfunction of Rett syndrome

Structure-guided T cell vaccine design could offer broad protection SARS-CoV-2 variants

NYU Abu Dhabi researchers use NMR spectroscopy to map the structure of specific nanobody

RNA-binding proteins represent a new class of drug targets for triple-negative breast cancer

Research pinpoints a molecular component responsible for modulating flu damage

UB scientists publish a detailed guide for producing mature human cells in a mouse embryo

Salivary markers of oxidative stress during severe COVID-19

The use of flavonoids as antiviral agents against SARS-CoV-2

Replication of SARS-CoV-2 in nasal ciliated cells could provide a new vaccination target

Genetic variants in a neuro-associated gene cause neurodevelopmental disorder, finds study

Immunity to SARS-CoV-2 could last longer than originally believed

Researchers reveal a promising target for designing anti-cancer therapies

Research associates prior encounter with seasonal coronavirus to milder COVID-19 symptoms

Engineered T cells prevent translational shutdown in SARS-CoV-2 infected cells

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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