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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Levels of mitochondrial DNA in the blood may predict chronic kidney disease risk

The health of blood cells' energy-producing mitochondria may predict a person's risk of developing chronic kidney disease (CKD), according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology.

22 Jan 2016

Simple & Efficient Protocol for Native Chromatin Immunoprecipitation

Chromatrap, a business unit of Porvair Sciences, announces a new patented protocol that is able to simply, quickly and efficiently enrich transcription factors from Native Chromatin.

From Chromatrap® - Porvair Sciences Ltd 22 Jan 2016

MDxHealth recognized with 2015 Global Frost & Sullivan Award for Technology Innovation

Based on its recent analysis of the prostate cancer diagnostics market, Frost & Sullivan recognizes MDxHealth with the 2015 Global Frost & Sullivan Award for Technology Innovation. To advance molecular diagnostic tests for urological cancers, MDxHealth supplemented its prostate cancer test, ConfirmMDx, with a urine-based "liquid-biopsy" test called SelectMDx.

21 Jan 2016

Paradigm, UnitedHealthcare sign contractual agreement for coverage of PCDx

Paradigm, a molecular information & Next Generation Sequencing corporation specializing in providing testing for cancer patients today announced that it has entered into a contractual agreement with UnitedHealthcare for coverage of PCDx.

21 Jan 2016

Scientists solve atomic structure of ubiquitin ligase complex that plays key role in protein degradation

Scientists at Sanford Burnham Prebys Medical Discovery Institute have solved the atomic structure of a unique ubiquitin ligase complex. Ubiquitin is best known for its role in protein degradation, but more recently seen as important for cell signaling, DNA repair, anti-inflammatory, and immune responses.

21 Jan 2016

Gene therapy holds considerable potential for safe, effective treatment of people with factor VII deficiency

Hematology researchers have used a single injection of gene therapy to correct a rare bleeding disorder, factor VII deficiency, in dogs. This success in large animals holds considerable potential for a safe, effective and long-lasting new treatment in humans with the same bleeding disorder.

21 Jan 2016

Study provides evidence for use of inherited genetic markers to improve melanoma prognostication

Melanoma is the most dangerous and lethal form of skin cancer. But just how long will a patient survive following the removal of a melanoma tumor? A more definitive answer to that question could come from new studies at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center. Researchers there have discovered an inherited genetic marker that might provide clinicians with a personalized tool to gauge an individual's survival and determine which patients require closer monitoring in the years following surgery.

21 Jan 2016

Discovery may help researchers identify new ways to attack malaria parasite

New anti-malarial drugs could be developed after researchers discovered a new mechanism used by the malaria parasite when it infects humans.

21 Jan 2016

UC Berkeley researchers make major improvement in CRISPR-Cas9 gene editing technology

University of California, Berkeley, researchers have made a major improvement in CRISPR-Cas9 technology that achieves an unprecedented success rate of 60 percent when replacing a short stretch of DNA with another.

21 Jan 2016

Variations in RANBP1 gene may disrupt brain signaling in neuropsychiatric conditions

Scientists have identified a gene that appears to play a significant role in raising a person's risk of having more severe subtypes of autism that co-occur with other genetic diseases, such as the chromosomal disorder 22q11.2 deletion syndrome.

20 Jan 2016

Depression in expectant parents during pregnancy increases risk of premature birth

Depression in both expectant mothers and fathers increases the risk of premature birth, finds a study published in BJOG: an International Journal of Obstetrics and Gynaecology (BJOG).

20 Jan 2016

Immune killer cells use microptosis pathway to kill intracellular parasites

The immune system's killer cells deliver a tightly controlled, 3-phase knockout punch that kills intracellular parasites through a novel pathway that an international team led by researchers from the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital have named "microptosis."

20 Jan 2016

Women who carry inherited fault in BRIP1 gene at higher risk of developing ovarian cancer

Women who carry an inherited fault in the gene BRIP1 are over three times more likely to develop ovarian cancer than those without the fault, according to a study published in the Journal of the National Cancer Institute.

20 Jan 2016

Rice scientists develop new tool to analyze thermal behaviors of DNA and RNA strands

Rice University scientists have developed a tool to speed the design of molecular diagnostics that depend on the specific recognition of pathogen DNA and RNA.

20 Jan 2016

Profectus begins Phase 1 clinical study of VesiculoVax-vectored Ebola virus vaccine

Profectus BioSciences, Inc., a clinical-stage vaccine company developing novel vaccines for the prevention and treatment of infectious diseases and the treatment of cancer, announced today the initiation of a Phase 1 clinical study of Profectus' VesiculoVax-vectored Ebola virus vaccine.

19 Jan 2016

RIKEN researchers discover how to reverse abnormal axonal development

Researchers at the RIKEN Brain Science Institute in Japan have discovered how to reverse the abnormal axonal development characteristic of CFEOM3, a congenital disease that affects the muscles that control eye movements.

19 Jan 2016

CRISPR/Cas9 gene editing technique could be controlled using RNA-based drugs

In just the past few years, researchers have found a way to use a naturally occurring bacterial system known as CRISPR/Cas9 to inactivate or correct specific genes in any organism. CRISPR/Cas9 gene editing activity runs continuously, though, leading to risk of additional editing at unwanted sites.

19 Jan 2016

Researchers suggest ways to make TB drugs more efficacious against mutations

Biophysicists have discovered why the bacteria that cause tuberculosis (TB) are naturally somewhat resistant to antibiotics known as fluoroquinolones. Their findings, based on mapping the detailed three-dimensional structure of the drugs interacting with an essential enzyme in the TB germ, also reveal why some TB drugs are more potent than others and suggest how drug developers can make fluoroquinolones more efficacious against mutations that make the lung disease drug resistant.

19 Jan 2016

Combination of PARP inhibitors and c-MET may benefit breast cancer patients

Findings from a new study reveal that PARP inhibitors, an emerging class of drugs being studied in cancer clinical trials, may be enhanced by combining them with inhibitors targeting an oncogene known as c-MET which is overexpressed in many cancers.

19 Jan 2016

Antivirulence antibiotics could evade resistance longer than traditional antibiotics

We've all seen the headlines. "Man found to be shedding virulent strain of polio"; "Virulent flu strain in Europe hits the economy"; "Most virulent strain of E. coli ever seen contains DNA sequences from plague bacteria."

19 Jan 2016

DNA News and Research

Further Reading

Levels of mitochondrial DNA in the blood may predict chronic kidney disease risk

Simple & Efficient Protocol for Native Chromatin Immunoprecipitation

MDxHealth recognized with 2015 Global Frost & Sullivan Award for Technology Innovation

Paradigm, UnitedHealthcare sign contractual agreement for coverage of PCDx

Scientists solve atomic structure of ubiquitin ligase complex that plays key role in protein degradation

Gene therapy holds considerable potential for safe, effective treatment of people with factor VII deficiency

Study provides evidence for use of inherited genetic markers to improve melanoma prognostication

Discovery may help researchers identify new ways to attack malaria parasite

UC Berkeley researchers make major improvement in CRISPR-Cas9 gene editing technology

Variations in RANBP1 gene may disrupt brain signaling in neuropsychiatric conditions

Depression in expectant parents during pregnancy increases risk of premature birth

Immune killer cells use microptosis pathway to kill intracellular parasites

Women who carry inherited fault in BRIP1 gene at higher risk of developing ovarian cancer

Rice scientists develop new tool to analyze thermal behaviors of DNA and RNA strands

Profectus begins Phase 1 clinical study of VesiculoVax-vectored Ebola virus vaccine

RIKEN researchers discover how to reverse abnormal axonal development

CRISPR/Cas9 gene editing technique could be controlled using RNA-based drugs

Researchers suggest ways to make TB drugs more efficacious against mutations

Combination of PARP inhibitors and c-MET may benefit breast cancer patients

Antivirulence antibiotics could evade resistance longer than traditional antibiotics

Understanding the DNA Damage Response in Innate Immunity eBook

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