Efficacy News and Research

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Sham-controlled trial of deep brain stimulation treatment for depression fails to show efficacy

Depression is a leading cause of disability worldwide, and treatment-resistant symptoms of depression have a terrible personal and societal cost. They can devastate lives, careers, and families. Some severely ill patients may be unable to attend to even the basic elements of self-care, while others attempt or complete suicide.

29 Jul 2015

Researchers establish safety, dosing of new drug for treating blood cancers

Researchers at University of California, San Diego School of Medicine have established the safety and dosing of a new drug for treating blood cancers. The findings are published online July 27 in The Lancet Haematology.

29 Jul 2015

VolitionRx selects Global Specimen Solutions to support U.S. market entry of NuQ colorectal cancer tests

VolitionRx Limited, a life sciences company focused on developing blood-based diagnostic tests for a broad range of cancer types and other conditions, today announced that it has engaged the services of a specialty specimen management clinical research organization, Global Specimen Solutions, Inc., to support initial U.S. market entry of its NuQ colorectal cancer tests.

28 Jul 2015

New technique improves survival time for glioblastoma patients by 50%

The rapid spread of a common and deadly brain tumor has been slowed down significantly in a mouse model by cutting off the way some cancer cells communicate, according to a team of researchers that includes UF Health faculty.

28 Jul 2015

Low-dose lithium lowers involuntary motor movements in mouse model of Parkinson's disease

Low-dose lithium reduced involuntary motor movements - the troubling side effect of the medication most commonly used to treat Parkinson's disease (PD) - in a mouse model of the condition that is diagnosed in about 60,000 Americans each year. The third in a series of studies from the Andersen lab involving PD and low-dose lithium, the results add to mounting evidence that low-doses of the psychotropic drug could benefit patients suffering from the incurable, degenerative condition.

28 Jul 2015

Twenty Radboud researchers receive Veni grant as part of Innovational Research Incentives Scheme

Twenty young and promising researchers from Nijmegen - eleven from Radboud University and nine from Radboudumc - are each to receive up to 250,000. NWO (The Netherlands Organisation for Scientific Research) is awarding the Veni grant as part of the Innovational Research Incentives Scheme.

25 Jul 2015

Trends, R&D progress, and predicted revenues in RNAi therapies

When will RNAi therapies reach the market? Visiongain's brand new report shows you potential revenues to 2025, assessing data, trends, opportunities and prospects there.

25 Jul 2015

$Steroid-refractory chronic GVHD trial results ‘overestimate’ treatment efficacy$

Steroid-refractory chronic GVHD trial results ‘overestimate’ treatment efficacy

Trial results for patients with steroid-refractory chronic graft versus host have overestimated the efficacies of treatments, suggests a meta-analysis published in The Lancet Haematology.

24 Jul 2015

First malaria vaccine a step closer

Mosquirix, the first malaria vaccine to be submitted for regulatory approval, has gained the support of the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP).

24 Jul 2015

EMA's CHMP recommends approval of Praluent (alirocumab) for use in patients with hypercholesterolemia

Regeneron Pharmaceuticals, Inc. and Sanofi today announced that the European Medicine Agency's Committee for Medicinal Products for Human Use has adopted a positive opinion for the marketing authorization of Praluent (alirocumab), recommending its approval for use in certain adult patients with hypercholesterolemia.

24 Jul 2015

Amgen announces submission of supplemental New Drug Application to FDA for Kyprolis (carfilzomib)

Amgen today announced the submission of a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration for Kyprolis (carfilzomib) for Injection to seek an expanded indication for the treatment of patients with a form of blood cancer, relapsed multiple myeloma, who have received at least one prior therapy.

23 Jul 2015

Omeros' OMS721 granted FDA Fast Track designation for treatment of atypical hemolytic uremic syndrome

Omeros Corporation today announced that the U.S. Food and Drug Administration granted Fast Track designation to OMS721 for the treatment of patients with atypical hemolytic uremic syndrome (aHUS). OMS721 is the company's lead human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), the key regulator of the lectin pathway of the immune system.

23 Jul 2015

Study looks at impact of amyloid imaging on diagnosis, management of patients with cognitive impairment

Eli Lilly and Company and Avid Radiopharmaceuticals, Inc., a wholly owned subsidiary of Lilly, today announced new data showing that knowledge of amyloid status as determined by Florbetapir F 18 Injection imaging altered diagnosis and management in the majority of patients being studied.

23 Jul 2015

UC San Diego researchers receive NIH grant to test efficacy of Sanofi's pain drug in treating Chagas disease

The National Center for Advancing Translational Sciences, part of the National Institutes of Health (NIH), has awarded James McKerrow, MD, PhD, director of the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, with a 2015 New Therapeutic Uses Award.

23 Jul 2015

Researchers design virtual IPE curriculum for students in medical and nursing schools

The Institute of Medicine has identified interprofessional education (IPE) as a key innovation for achieving the triple aim of better care, better outcomes and reduced health care costs. Yet, a shortage of qualified faculty and difficulty with aligning learners' schedules often prevent sustainable and scalable IPE.

22 Jul 2015

New CHLA study uncovers baseline characteristics of transyouth seeking care for gender dysphoria

Johanna Olson, MD, and her colleagues at Children's Hospital Los Angeles, provide care for the largest number of transyouth in the U.S. and have enrolled 101 patients in a study to determine the safety and efficacy of treatment that helps patients bring their bodies into closer alignment with their gender of identity.

22 Jul 2015

Study reveals potential new therapeutic target for depression treatment

Increasing the levels of a signaling molecule found in the brain can positively alter response to stress, revealing a potential new therapeutic target for treatment of depression, UT Southwestern Medical Center researchers said.

22 Jul 2015

Young, single South African women adhere well to daily PrEP regimen to prevent HIV infection

A clinical study funded by the National Institutes of Health has found that young, single black women in South Africa adhered to a daily pill regimen to prevent HIV infection--an HIV prevention strategy known as pre-exposure prophylaxis, or PrEP. This finding is the first strong indication that this population at substantial HIV risk could accept and reliably adhere to daily PrEP dosing.

22 Jul 2015

Current and new treatments for AMD: an interview with Dr Alan Cruess, AMD Alliance International

For two decades beginning in the late 1970’s through 2001, clinicians relied upon laser photocoagulation in the treatment of wet AMD caused by choroidal neovascularization. Attempts to obliterate the neovascular lesions often led to acute central visual loss and often, even with modest success, the lesions recurred with even more vision loss.

21 Jul 2015

Check-Cap provides corporate update, reports financial results for second quarter 2015

Check-Cap Ltd., a clinical stage medical diagnostics company engaged in the development of an ingestible capsule for preparation-free, colorectal cancer screening, today provided a corporate update and announced financial results for the second quarter, ended June 30, 2015.

21 Jul 2015

Efficacy News and Research

Sham-controlled trial of deep brain stimulation treatment for depression fails to show efficacy

Researchers establish safety, dosing of new drug for treating blood cancers

VolitionRx selects Global Specimen Solutions to support U.S. market entry of NuQ colorectal cancer tests

New technique improves survival time for glioblastoma patients by 50%

Low-dose lithium lowers involuntary motor movements in mouse model of Parkinson's disease

Twenty Radboud researchers receive Veni grant as part of Innovational Research Incentives Scheme

Trends, R&D progress, and predicted revenues in RNAi therapies

Steroid-refractory chronic GVHD trial results ‘overestimate’ treatment efficacy

First malaria vaccine a step closer

EMA's CHMP recommends approval of Praluent (alirocumab) for use in patients with hypercholesterolemia

Amgen announces submission of supplemental New Drug Application to FDA for Kyprolis (carfilzomib)

Omeros' OMS721 granted FDA Fast Track designation for treatment of atypical hemolytic uremic syndrome

Study looks at impact of amyloid imaging on diagnosis, management of patients with cognitive impairment

UC San Diego researchers receive NIH grant to test efficacy of Sanofi's pain drug in treating Chagas disease

Researchers design virtual IPE curriculum for students in medical and nursing schools

New CHLA study uncovers baseline characteristics of transyouth seeking care for gender dysphoria

Study reveals potential new therapeutic target for depression treatment

Young, single South African women adhere well to daily PrEP regimen to prevent HIV infection

Current and new treatments for AMD: an interview with Dr Alan Cruess, AMD Alliance International

Check-Cap provides corporate update, reports financial results for second quarter 2015

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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