Genes News and Research

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Condensate-based strategy protects synthetic gene circuits across cell generations

Genetic engineers can design and assemble sophisticated gene circuits to program cells with new functions, but important signaling molecules can become diluted as these cells grow and divide, causing the synthetic gene circuits to lose their new functions.

7 Nov 2025

Protein linked to cancer plays key role in wound healing

When doctors detect elevated levels of SerpinB3 in a blood test, it can signal that something is seriously wrong, from hard-to-treat cancers to severe inflammatory conditions.

7 Nov 2025

Multiple protein forms from a single gene offer fresh insight into rare disease mechanisms

Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients through a collaboration with Boston Children's Hospital.

7 Nov 2025

Comprehensive kinase atlas reveals new insights into cell signaling and disease

The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's "tail" called phosphorylation patterns.

7 Nov 2025

Machine learning advances human-centric drug toxicity prediction

In the UK, there was a case where TGN1412, an immunotherapy under development, triggered a cytokine storm within hours of administration to humans, leading to multiple organ failure.

7 Nov 2025

Researchers refine tools to map DNA’s 3D structure inside cells

DNA isn't just a long string of genetic code, but an intricate 3D structure folded inside each cell. That means the tools used to study DNA need to be just as sophisticated-able to read not only the code itself, but how it's arranged in space.

6 Nov 2025

Inflammation identified as a key driver in the earliest stages of lung cancer

By creating high-resolution cellular and molecular visual maps of lung cancer before and during development, researchers at The University of Texas MD Anderson Cancer Center have discovered that the earliest stages of lung cancer may be driven by inflammation, suggesting that targeting proinflammatory pathways could be an early intervention approach.

6 Nov 2025

Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections

Lowering the transcription factor PU.1 reprograms microglia into a neuroprotective, lymphoid-like state that compacts amyloid, blocks tau spread, and preserves synapses in Alzheimer’s disease. Microglial CD28 signaling helps restrain inflammation, revealing a regulatory switch that may inform future immunotherapies targeting microglia rather than neurons.

6 Nov 2025

Two main methods for discovering disease genes reveal distinct aspects of biology

The two main approaches for discovering disease genes reveal distinct aspects of biology, a new study shows. While both methods are widely used, the research found that they identify different genes, with major implications for drug development.

6 Nov 2025

Maternal type 1 diabetes confers a protective effect in children through epigenetic programming

Children with a family history of type 1 diabetes (T1D) have an increased risk of developing the disease.

6 Nov 2025

Newly identified microglia subtype offers protection against Alzheimer’s disease

In Alzheimer's disease, the leading cause of dementia, microglia-the brain's immune defenders-can act as both protectors and aggressors, shaping how the disease progresses.

5 Nov 2025

NYU Langone Health begins first clinical trial of gene-edited pig kidney transplants

The first surgery in a clinical trial testing the safety and efficacy of gene-edited pig kidney transplants in patients with end-stage renal disease was recently performed at NYU Langone Health.

5 Nov 2025

MIT researchers identify new vaccine targets to fight tuberculosis

A large-scale screen of tuberculosis proteins has revealed several possible antigens that could be developed as a new vaccine for TB, the world's deadliest infectious disease.

5 Nov 2025

Bowel cancer’s “Big Bang” moment reveals how the disease takes shape

Like the astronomical explosion that kickstarted the universe, bowel cancer has a "Big Bang" moment which determines how it will grow, according to new research from Cancer Research UK and Wellcome Trust-funded scientists.

5 Nov 2025

USC-led study advances understanding of prostate cancer genetics in Black men

New prostate cancer research from an international team led by the Center for Genetic Epidemiology at the Keck School of Medicine of USC has yielded discoveries that could improve screening and treatment for patients of African ancestry.

5 Nov 2025

Breakthrough study reveals how rabies virus uses few proteins to hijack cells

New antivirals and vaccines could follow the discovery by Australian researchers of strategies used by viruses to control our cells.

5 Nov 2025

Redefining control and consistency in anaerobic microbiome workflows

Explore how smart automation enables precise, reproducible workflows in anaerobic microbiome research, improving accuracy and experimental control.

From Molecular Devices UK Ltd 5 Nov 2025

$Adipose tissue stem cells show promise in treating osteoporotic vertebral fractures$

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Genes News and Research

Condensate-based strategy protects synthetic gene circuits across cell generations

Protein linked to cancer plays key role in wound healing

Multiple protein forms from a single gene offer fresh insight into rare disease mechanisms

Comprehensive kinase atlas reveals new insights into cell signaling and disease

Machine learning advances human-centric drug toxicity prediction

Researchers refine tools to map DNA’s 3D structure inside cells

Inflammation identified as a key driver in the earliest stages of lung cancer

Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections

Two main methods for discovering disease genes reveal distinct aspects of biology

Maternal type 1 diabetes confers a protective effect in children through epigenetic programming

Newly identified microglia subtype offers protection against Alzheimer’s disease

NYU Langone Health begins first clinical trial of gene-edited pig kidney transplants

MIT researchers identify new vaccine targets to fight tuberculosis

Bowel cancer’s “Big Bang” moment reveals how the disease takes shape

USC-led study advances understanding of prostate cancer genetics in Black men

Breakthrough study reveals how rabies virus uses few proteins to hijack cells

Redefining control and consistency in anaerobic microbiome workflows

Adipose tissue stem cells show promise in treating osteoporotic vertebral fractures

PTGES3 emerges as key regulator of androgen receptor in prostate cancer

Hidden cell structures reveal a common weakness in leukemia

eBook: Using iPSCs models for human disease research and drug discovery eBook

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