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New machine-learning approach discovers mechanism that helps antibiotics kill bacteria

Most antibiotics work by interfering with critical functions such as DNA replication or construction of the bacterial cell wall.

10 May 2019

Study explains why some football players with SCT experience adverse clinical outcomes

A recent study published in Southern Medical Journal, led by researchers from the University of South Florida identifies a genetic variation known to affect sickle cell disease symptomology.

10 May 2019

Genetic test for low birth weight on the horizon

Researchers have successfully identified 190 genetic factors associated with a low birth weight. They hope that this may one day be used to develop a universal genetic test.

3 May 2019

Combination of biological markers and genetic changes can predict radiation sensitivity

Latest results from a project to discover what makes a cancer patient more likely to suffer adverse side-effects after radiotherapy have shown that a combination of biological markers and certain genetic changes can predict radiation sensitivity.

30 Apr 2019

New study delves deeper into individual genomic differences than ever before

Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or "spelling mistakes" in the DNA sequence, but even more variation comes from structural variants, which include additions, deletions and rearrangements of large segments of DNA.

17 Apr 2019

Molecule metabolite variations in breast milk may hold risk factors for childhood obesity

New research suggests the composition of breast milk in normal weight mothers differs from that of overweight mothers, and that variations in small molecule metabolites found in breast milk are possible risk factors for childhood obesity.

11 Apr 2019

Study suggests novel therapeutic strategy for ALS

In a study published online in Brain on April 1, researchers from Dr. XU Jin's lab at the Institute of Neuroscience of the Chinese Academy of Sciences and their collaborators revealed a new cellular mechanism for amyotrophic lateral sclerosis, suggested a novel therapeutic strategy targeting the RNA degradation pathway, and identified an asthma drug as a potential medication for ALS.

9 Apr 2019

Air Force develops genetic test to predict mental performance

A research psychologist at the Air Force Research Laboratory can predict your mental performance from a cheek swab or blood sample.

22 Mar 2019

Knowing causative genes of osteoporosis may open door to more effective treatments

Scientists have harnessed powerful data analysis tools and three-dimensional studies of genomic geography to implicate new risk genes for osteoporosis, the chronic bone-weakening condition that affects millions of people.

22 Mar 2019

Researchers track effects of epigenetic marks carried by sperm chromosomes

As an organism grows and responds to its environment, genes in its cells are constantly turning on and off, with different patterns of gene expression in different cells. But can changes in gene expression be passed on from parents to their children and subsequent generations?

20 Mar 2019

Natural speed limit on DNA replication sets pace for life's first steps

Fruit flies make for stingy mothers, imparting only a portion of the genetic building blocks their offspring need to survive. The rest must be produced by the fertilized egg in its first few steps of growth.

15 Mar 2019

Scientists introduce a simple, reliable method for universal isothermal DNA amplification

Whether revealing a perpetrator with DNA evidence, diagnosing a pathogen, classifying a paleontological discovery, or determining paternity, the duplication of nucleic acids (amplification) is indispensable.

13 Mar 2019

DNA sequencing method could aid development of anticancer drugs

DNA is small. Really, really, small. So, when researchers want to study the structure of a single-stranded DNA, they can't just pull out their microscopes: they have to get creative.

8 Mar 2019

World-first fact-checking program tackles problem of incorrect biomedical research results

Cancer researcher Professor Jennifer Byrne from the University of Sydney is hoping to change this with the creation of a world-first fact-checking program that is tackling the problem of incorrectly published biomedical research results, whether intentional or otherwise.

5 Mar 2019

Cancer genes’ mutational status influenced by their evolutionary age, regulatory functions

Researchers have provided new insight on why some genes that formed during the evolution of the earliest animals on earth are particularly impaired (or dysregulated) by specific mechanisms during cancer development.

26 Feb 2019

Biophysicists visualize atomic-level dynamics of largest protein-degrading machine

Protein dynamics are essential for their functions. Protein nanomachines made of multiple protein molecules are highly dynamics during their actions on their functional targets, sometime called substrates.

26 Feb 2019

Study: Cancer stem-like cells are maintained by MTHFD2 mitochondrial metabolic enzyme

An increase in the incidence and mortality rate of cancer has been noted worldwide, especially for lung cancer.

22 Feb 2019

Microbiologists identify enzyme that makes Helicobacter so adaptable

The bacterial pathogen Helicobacter pylori owes its worldwide distribution to its genetic adaptability. Ludwig-Maximilians-Universitaet Munich microbiologists have identified an enzyme that plays a vital role in the flexible control of global gene expression in the species.

13 Feb 2019

New discovery can explain resistance of cancer types to fatty acid metabolism inhibition

Fatty acid metabolism is an essential process in tumor growth and proliferation. Despite different attempts to block fatty acid metabolism as a therapeutic strategy to reduce tumor size and growth, the outcome was not always positive.

7 Feb 2019

Researchers describe first case of patient affected by dysfunctions in SLC28 gene family

A research team has described the first case of a patient affected by dysfunctions in a nucleoside transporter of the SLC28 gene family, which brings a set of genes which were not related to human pathologies in the scientific bibliography so far.

5 Feb 2019