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Metformin could potentially improve pregnancy outcomes in women with insulin resistance

Women who are obese, have type 2 diabetes or a family history of type 2 diabetes could one day have more successful pregnancies because of a study at Washington University School of Medicine in St. Louis.

10 Sep 2007

New method to create natural drug products

Until now, only the intricate machinery inside cells could take a mix of enzyme ingredients, blend them together and deliver a natural product with an elaborate chemical structure such as penicillin.

5 Sep 2007

Low level of neuronal receptor LR11 linked to Alzheimer's disease

Results of a new study indicate a strong link between the loss of the neuronal receptor LR11and onset of mild cognitive impairment (MCI), often a harbinger of Alzheimer's disease.

5 Sep 2007

N-acetylcysteine may not be as safe as once thought

Certain preparations taken to enhance athletic performance or stave off disease contain an anti-oxidant that could cause harm.

5 Sep 2007

Study identifies osteopontin as a key player in the body's immune response to chronic stress

Osteopontin (OPN), a protein molecule involved in many different cellular processes, plays a significant role in immune deficiency and organ atrophy following chronic physiological stress, resulting in increased susceptibility to illness.

4 Sep 2007

Retinoblastoma tumor suppressor may predict chemotherapy effectiveness

A common molecular pathway could help physicians predict which lung cancer patients will benefit from chemotherapy drugs, according to new research from a multidisciplinary team at the University of Cincinnati (UC).

3 Sep 2007

Cell that triggers symptoms in allergy attacks can also limit damage

A blood cell known as a troublemaker for triggering the itch and inflammation in allergy attacks, the mast cell, can also calm down the flare-ups, researchers from Stanford University School of Medicine have found.

3 Sep 2007

Does physical activity provide a molecular key to longevity?

Fitness and physical exercise are among the most neglected means to improve prognosis. They are the healthiest cardiovascular intervention. Even cardiologists focus on pharmacological treatment and evaluate classical risk factors without asking about daily exercise or objective measures of physical capacity. It is surprising considering the strong data that underscores the survival benefit of regular exercise training.

2 Sep 2007

Brain's impaired ability to sense glucose might play role in type 2 diabetes

New findings from studies in mice suggest that defects in the brain's ability to respond to glucose play a role in the development of non-insulin dependent (type 2) diabetes, and that a high-fat diet may contribute to impairing brain cells' ability to regulate glucose throughout the body.

30 Aug 2007

Researchers unlock mystery of a third olfactory system

Researchers at the University of Maryland School of Medicine have found a "nose within the nose," a unique olfactory system within the noses of mice that is able to "smell" hormones involved in regulating water and salt balance in the body.

30 Aug 2007

Researchers dispute immortal strand hypothesis

How do adult stem cells protect themselves from accumulating genetic mutations that can lead to cancer?

30 Aug 2007

FDA grants orphan drug designation to TREANDA

Cephalon, Inc. announced today that the U.S. Food and Drug Administration (FDA) Office of Orphan Products Development granted orphan drug designation for the company's investigational therapy, TREANDA (bendamustine HCl), for the treatment of chronic lymphocytic leukemia (CLL).

29 Aug 2007

Secret to bone's strength

Scientists and engineers are eager to understand the secret behind bone's lightweight toughness so they can mimic it in the design of new materials, but previous studies have revealed a number of different strength mechanisms at different scales of focus, rather than a single theory.

28 Aug 2007

New mathematical models for circadian rhythm

The internal clock in living beings that regulates sleeping and waking patterns -- usually called the circadian clock -- has often befuddled scientists due to its mysterious time delays.

28 Aug 2007

New understanding of what makes a major global bacterial infection deadly

Researchers believe they have discovered why a bacterial lung infection is so lethal in the early stages, and it's not what medical authorities had thought, according to research published in the journal Immunity.

28 Aug 2007

Blocking angiogenesis signaling from inside cell may lead to serious health problems

Angiogenesis inhibitors that block a tumor's development of an independent blood supply have been touted as effective cancer fighters that result in fewer side effects than traditional chemotherapy.

24 Aug 2007

Binding up iron in the brain to combat Parkinson's and Alzheimer's

Duke University chemists are developing ways to bind up iron in the brain to combat the neurological devastation of Parkinson's and Alzheimer's diseases.

24 Aug 2007

Light may play a much more important role in bacterial life than has previously thought

The bacteria that cause brucellosis can sense light and use the information to regulate their virulence, according to a study in the August 24 issue of the journal Science.

24 Aug 2007

Scientist uses novel mass spectrometer to weigh virus particle

With unprecedented sensitivity, Carnegie Mellon University's Mark Bier has characterized large viral particles and bulky von Willebrand factors using a novel mass spectrometer.

24 Aug 2007

New technology for keeping liver cells alive inside bioartificial liver-assist devices

Such devices enable people who are suffering from acute liver failure to survive while their own liver cells regenerate, or until they receive a liver transplant. The person's blood or plasma circulates through the device. Inside, living cells -- usually pig or human liver cells -- perform normal liver functions.

24 Aug 2007