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NPL scientists mimick the ways viruses infect human cells and deliver genetic material

Scientists at the National Physical Laboratory (NPL) have mimicked the ways viruses infect human cells and deliver their genetic material. The research hopes to apply the approach to gene therapy - a therapeutic strategy to correct defective genes such as those that cause cancer.

12 Aug 2011

Single engineered protein blocks two related angiogenic receptors

Cancer needs blood. In fact, some cancer medications work solely to slow or prevent cancer cells from creating new capillaries, choking off their much-needed blood and nutrient supply to halt the growth of tumors.

12 Aug 2011

Scientists identify new therapeutic target for ADHD, other neuropsychiatric disorders

A biochemical pathway long associated with diarrhea and intestinal function may provide a new therapeutic target for treating ADHD other neuropsychiatric disorders, according to a team of scientists from China and the United States reporting Aug. 11 in Science.

12 Aug 2011

SIGMAR1 gene mutation associated with development of juvenile ALS

Researchers from the Kingdom of Saudi Arabia have identified a mutation on the SIGMAR1 gene associated with the development of juvenile amyotrophic lateral sclerosis.

12 Aug 2011

Blocking type 2 receptor reduces PDA cell growth with the activation of AMPK enzyme

Pancreatic cancer researchers at Thomas Jefferson University have shown, for the first time, that blocking a receptor of a key hormone in the renin-angiotensin system (RAS) reduces cancer cell growth by activating the enzyme AMPK to inhibit fatty acid synthase, the ingredients to support cell division.

11 Aug 2011

Research: p38α MAPK protein plays a role in addiction, depression-like behavior

Researchers studying mice are getting closer to understanding how stress affects mood and motivation for drugs.

11 Aug 2011

Higher protein intake helps postmenopausal obese women lose more weight

Dieting postmenopausal women who want to avoid losing muscle as they lose fat should pay attention to a new University of Illinois study. Adding protein throughout the day not only holds hunger pangs at bay so that dieters lose more weight, it keeps body composition-the amount of fat relative to muscle-in better proportion.

11 Aug 2011

New research uncovers role of p38alpha in mood disorders, addiction

Stressful experiences increase addictive drug consumption and can precipitate bouts of anxiety or depression in vulnerable people. Although the mechanisms linking stress and human behaviors are not well understood, animal models of some aspects of these behaviors have been developed and have been used to define some of the molecular events that may be responsible for stress vulnerability in people.

11 Aug 2011

New findings on human brain's photosensitivity

Valkee, inventor of the world's first bright-light headset, and scientists from the University of Oulu will present new findings on human brain's photosensitivity at the Scandinavian Physiology Society Annual Meeting 2011, August 12-14.

11 Aug 2011

Red meat consumption may increase risk of type 2 diabetes

A new study by Harvard School of Public Health (HSPH) researchers finds a strong association between the consumption of red meat-particularly when the meat is processed-and an increased risk of type 2 diabetes.

11 Aug 2011

Red and processed meat ‘ups’ risk for type 2 diabetes

A new study conducted by researchers at the Harvard School of Public Health says that a diet heavy on red meat and processed foods can significantly increase a person’s chances of developing type 2 diabetes. The study results were published in the American Journal of Clinical Nutrition.

11 Aug 2011

Modified spider-silk proteins for nonviral gene delivery

Genetically engineered spider silk could help overcome a major barrier to the use of gene therapy in everyday medicine, according to a new study that reported development and successful initial laboratory tests of such a material. It appears in ACS' journal Bioconjugate Chemistry.

11 Aug 2011

Biomarker may signal whether common back pain treatment will work

A new study from researchers at the Stanford University School of Medicine has identified a unique protein complex that can be used to predict whether an epidural steroid injection will help relieve pain caused by a herniated disc in the lower spine.

10 Aug 2011

Cancer-causing fusion protein works by silencing tumor suppressor gene IL-2Rγ

Mariusz A. Wasik, MD, professor of Pathology and Laboratory Medicine, and Qian Zhang, MD, PhD, research assistant professor, both from the Perelman School of Medicine at the University of Pennsylvania, and their colleagues, found that a cancer-causing fusion protein works by silencing the tumor suppressor gene IL-2R common gamma-chain.

10 Aug 2011

Nesfatin-1 protein may help reduce body weight and blood sugar

A newly-identified protein may hold the key to keeping appetite and blood sugar in check, according to a study by York University researchers.

10 Aug 2011

Scientist determines how nyctalopin gene makes night vision possible

A scientist from the Florida campus of The Scripps Research Institute has determined how a particular gene makes night vision possible. The study, which was published in the August 10, 2011 edition of The Journal of Neuroscience, focuses on a gene called nyctalopin. Mutations in the gene result in inherited "night blindness," a loss of vision in low-light environments.

10 Aug 2011

Trastuzumab drug increases risk of heart problems in elderly breast cancer patients

The first study to investigate the effect of the breast cancer drug trastuzumab (Herceptin) on heart and vascular function in elderly patients has found that it increases the risk of heart problems, particularly in women with a history of heart disease, diabetes or both.

10 Aug 2011

Scientists reveal why human heart has little regenerative capacity

Stem cell researchers at UCLA have uncovered for the first time why adult human cardiac myocytes have lost their ability to proliferate, perhaps explaining why the human heart has little regenerative capacity.

10 Aug 2011

New genetic cause of retinitis pigmentosa

Combining the expertise of several different labs, University of Iowa researchers have found a new genetic cause of the blinding eye disease retinitis pigmentosa (RP) and, in the process, discovered an entirely new version of the message that codes for the affected protein.

10 Aug 2011

Researchers identify molecular pathway behind inflammation, mucus production in asthma

Researchers at the University of Pittsburgh School of Medicine have identified a molecular pathway that helps explain how an enzyme elevated in asthma patients can lead to increased mucus production and inflammation that is characteristic of the lung condition.

9 Aug 2011