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Can GLP-1 drugs slow neurodegeneration? New review finds promising signals but limited clinical proof

This review examines how GLP-1 receptor agonists may influence neurodegenerative disease biology through metabolic, inflammatory, mitochondrial, and proteostasis pathways. Evidence from mechanistic, preclinical, and early clinical studies suggests potential neuroprotective effects, but definitive disease-modifying benefit remains unproven.

17 Feb 2026

ASH releases new guidelines for treating leukemia in adolescents and young adults

The American Society of Hematology (ASH) released guidelines on frontline management of acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYAs), as well as the management of relapsed or refractory disease in this population.

12 Feb 2026

Case report examines potential cancer risks after mRNA vaccination

A new case report was published in Volume 17 of Oncotarget on February 6, 2026, titled "Exploring the potential link between mRNA COVID-19 vaccinations and cancer: A case report with a review of haematopoietic malignancies with insights into pathogenic mechanisms."

12 Feb 2026

Researchers identify a previously unknown cellular barrier in the brain

VIB and Ghent University researchers have identified and characterized a previously unknown cellular barrier in the brain, which sheds new light on how the brain is protected from the rest of the body.

12 Feb 2026

Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study

Researchers engineered CD4+ chimeric antigen receptor T cells targeting fibrillar amyloid beta and tested them in a mouse Alzheimer model. The preclinical study showed reduced amyloid pathology and altered neuroimmune responses, supporting CAR-T immunotherapy as a potential future Alzheimer strategy.

11 Feb 2026

Semaglutide lowers cardiovascular events even without major weight loss, researchers report

Semaglutide reduced major adverse cardiovascular events in adults with overweight or obesity and established cardiovascular disease regardless of baseline adiposity. Cardiovascular benefit was largely independent of overall weight loss, with waist circumference reduction explaining only part of the effect.

11 Feb 2026

Northwestern scientists develop advanced organoid model for human spinal cord injury

Northwestern University scientists have developed the most advanced organoid model for human spinal cord injury to date.

11 Feb 2026

Review links betel nut addiction to cancer, heart disease, and metabolic risks

This review examines the epidemiology, health risks, neurobiological mechanisms, and emerging treatments related to betel nut addiction worldwide. It highlights strong links with oral cancer, cardiometabolic disease, and addiction pathways while noting limited established therapies and the need for coordinated public health strategies.

11 Feb 2026

FDA label update expands CAR T access for primary CNS lymphoma

Dana-Farber Cancer Institute-led research helped drive an FDA label update for axicabtagene ciloleucel (Yescarta) that removes a prior exclusion for patients with primary central nervous system lymphoma, a rare and aggressive lymphoma of the brain and spinal cord.

9 Feb 2026

Brain immune cells regulate new neuron formation in adults

Breakthrough research from the University of Cincinnati College of Medicine is revealing how immune cells in the adult brain can regulate the generation of new neurons.

9 Feb 2026

EBV-linked killer T cells implicated in multiple sclerosis

Researchers at UC San Francisco have uncovered a new clue to how Epstein-Barr virus (EBV) could contribute to multiple sclerosis (MS), a chronic autoimmune disease that affects nearly one million Americans.

5 Feb 2026

Too many antioxidants may negatively affect future offspring

Antioxidants have been marketed as miracle supplements, touted for preventing chronic diseases and cancers; treating COPD and dementia; and slowing aging.

4 Feb 2026

Study identifies genetic fingerprint of neuropathic pain neurons

Researchers from The University of Texas at Dallas and their international colleagues have determined the molecular signature of human sleeping - or silent - nociceptors: sensory neurons that are unresponsive to touch or pressure yet are key culprits in neuropathic pain.

4 Feb 2026

Ride Cincinnati grant funds research on immune activating wafer for glioblastoma treatment

A multidisciplinary team of University of Cincinnati Cancer Center researchers has received a $40,000 Ride Cincinnati grant to study a delayed release preparation, or wafer, of an immunostimulatory molecule to stimulate the central nervous system (CNS) immune system after surgery to remove glioblastoma, a form of primary brain cancer.

3 Feb 2026

Regulating microglial phagocytosis through immunotherapy could slow Parkinson's disease progression

By analyzing tissue from patients with Parkinson's disease, and animal and cellular models of the disease, a research team from the Institut de Neurociències of the UAB has shown that the main immune cells of the brain become reactive and overexpress certain receptors that promote the elimination of dopaminergic neurons, even when these neurons are still functional.

2 Feb 2026

Lab-grown corticospinal neurons offer new models for ALS and spinal injuries

Researchers have developed a way to grow a highly specialized subset of brain nerve cells that are involved in motor neuron disease and damaged in spinal injuries.

29 Jan 2026

Silencing a specific brain circuit can prevent and reverse chronic pain

A neural circuit hidden in an understudied region of the brain plays a critical role in turning temporary pain into pain that can last months or years, according to new University of Colorado Boulder research.

27 Jan 2026

Gut problems may shape Parkinson’s disease progression through the gut-brain axis

This narrative review examines how gastrointestinal dysfunction, gut dysbiosis, and altered gut-brain axis signaling are closely associated with the onset and progression of Parkinson’s disease. It synthesizes evidence supporting a possible bottom-up disease model while highlighting integrative, gut-targeted strategies as adjuncts to symptom management rather than proven disease-modifying therapies.

27 Jan 2026

How modern lifestyles reprogram the gut microbiome and shape disease risk

Modern lifestyle factors such as circadian disruption, sleep deprivation, stress, and exercise reshape the gut bacteriome and its metabolic outputs. These microbiome changes are linked to immune, metabolic, and cancer-related pathways, largely through evidence from animal models and observational human studies.

27 Jan 2026

New research initiative aims to develop retinal screening tool for Alzheimer's

The human eye may literally become a window revealing the earliest signals of Alzheimer's disease, thanks to a new federally funded research initiative at Oregon Health & Science University.

27 Jan 2026

Central Nervous System News and Research

Can GLP-1 drugs slow neurodegeneration? New review finds promising signals but limited clinical proof

ASH releases new guidelines for treating leukemia in adolescents and young adults

Case report examines potential cancer risks after mRNA vaccination

Researchers identify a previously unknown cellular barrier in the brain

Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study

Semaglutide lowers cardiovascular events even without major weight loss, researchers report

Northwestern scientists develop advanced organoid model for human spinal cord injury

Review links betel nut addiction to cancer, heart disease, and metabolic risks

FDA label update expands CAR T access for primary CNS lymphoma

Brain immune cells regulate new neuron formation in adults

EBV-linked killer T cells implicated in multiple sclerosis

Too many antioxidants may negatively affect future offspring

Study identifies genetic fingerprint of neuropathic pain neurons

Ride Cincinnati grant funds research on immune activating wafer for glioblastoma treatment

Regulating microglial phagocytosis through immunotherapy could slow Parkinson's disease progression

Lab-grown corticospinal neurons offer new models for ALS and spinal injuries

Silencing a specific brain circuit can prevent and reverse chronic pain

Gut problems may shape Parkinson’s disease progression through the gut-brain axis

How modern lifestyles reprogram the gut microbiome and shape disease risk

New research initiative aims to develop retinal screening tool for Alzheimer's

Event guide: The 7th CNS Drug Delivery Summit eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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