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New TIL therapy improves treatment's effectiveness in patients with metastatic gastrointestinal cancers

A new form of tumor infiltrating lymphocyte (TIL) therapy, a form of personalized cancer immunotherapy, dramatically improved the treatment's effectiveness in patients with metastatic gastrointestinal cancers, according to results of a clinical trial led by researchers at the National Institutes of Health (NIH).

1 Apr 2025

Material from nasal lavage provides a basis for assessing COPD

Early diagnosis of COPD, chronic obstructive pulmonary disease, increases the quality of life of the patient and the efficacy of available treatments.

28 Mar 2025

Microneedles accelerate diabetic wound healing in preclinical models

Diabetic wounds often lead to severe complications that can result in amputations. These chronic and non-healing wounds are marked by persistent inflammation, affecting more than six per cent of the global population.

26 Mar 2025

Study shows red wine biomarkers in urine can predict inflammation levels

Researchers found that specific metabolites of resveratrol in urine accurately reflect red wine consumption. These biomarkers were linked to reduced inflammation in older adults at cardiovascular risk, unlike traditional food surveys.

25 Mar 2025

Epstein-Barr virus triggers inflammatory cell death in ulcerative colitis

Ulcerative colitis (UC) is a chronic, relapsing disease that causes painful inflammation and ulcers in the colon.

24 Mar 2025

Targeting brain’s waste removal system may help combat cognitive decline

As aging bodies decline, the brain loses the ability to cleanse itself of waste, a scenario that scientists think could be contributing to neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease, among others.

21 Mar 2025

IL-12 targeting could open pathways for new Alzheimer's treatments

Researchers from Charité – Universitätsmedizin Berlin and the Max Delbrück Center have detailed the precise mechanism through which the inflammatory signaling molecule IL-12 contributes to Alzheimer's disease.

17 Mar 2025

How gut health shapes heart disease risk — and what you can do about it

A new review highlights how gut microbiome imbalances contribute to cardiovascular disease by altering short-chain fatty acids, TMAO, and inflammatory pathways. The study emphasizes the potential of prebiotics, probiotics, and dietary changes to restore gut health and reduce heart disease risk.

13 Mar 2025

How eating more calories helps lower asthma risk in children - but only up to a point

Children and adolescents in the U.S. who consume higher amounts of dietary energy have a lower risk of asthma, but this protective effect stops beyond 56.442 kcal per kilogram of body weight per day. The study found an L-shaped relationship, suggesting that insufficient energy intake may heighten asthma risk.

12 Mar 2025

Study elucidates mechanism behind bacterial cancer therapy

A research team led by Prof. Liu Chenli from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences (CAS) and Prof. Xiao Yichuan from the Shanghai Institute of Nutrition and Health of CAS elucidated the mechanism behind bacterial cancer therapy using a genetically engineered bacterial strain.

3 Mar 2025

Stress & Distress: Designing clinical trials for maximum efficacy

To be decided by the editor

From Atlantia Clinical Trials 28 Feb 2025

Vaping while pregnant isn't harmless—study uncovers risks to newborn lung health

Researchers found that e-cigarette exposure during pregnancy can disrupt fetal lung development, increase oxidative stress, and heighten the risk of respiratory diseases in newborns.

27 Feb 2025

Novel form of life-threatening skin disease identified using innovative diagnostic platform

A significant number of Americans experience chronic inflammatory skin conditions with no pinpointed cause and often no effective treatments beyond symptom management.

24 Feb 2025

Vitamin E significantly improves liver health in MASH patients, new study finds

A 96-week clinical trial found that 300 mg of Vitamin E significantly improved liver histology and reduced inflammation in patients with MASH, with no major safety concerns reported.

19 Feb 2025

Common antidepressant Fluoxetine protects from sepsis-induced death

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19 Feb 2025

Sweat fails to match blood in tracking inflammation after heart attacks

Researchers found that while sweat biomarkers remain stable, plasma biomarkers show significant inflammatory changes after a heart attack, highlighting the limitations of sweat analysis for tracking recovery.

17 Feb 2025

Vaping and gum health: How does it compare to smoking?

A systematic review found that e-cigarette users show increased plaque and inflammation markers compared to non-smokers, though their gum health fares better than traditional smokers. However, the certainty of these findings is low due to study bias.

16 Feb 2025

A step toward precision medicine: New drug targets for heart failure

Researchers identify several promising drug targets for heart failure and its clinical subtypes.

14 Feb 2025

How immune cells and neurons secretly shape brain health, behavior, and disease

Scientists explore how the immune and nervous systems constantly communicate, influencing brain diseases, behavior, and repair while shaping responses to environmental factors like sleep, diet, and pollution.

13 Feb 2025

Olpasiran significantly lowers "bad cholesterol" linked to cardiovascular risk

The RNA inhibitor olpasiran significantly reduces a type of "bad cholesterol" that's associated with a high risk of cardiovascular events, according to results from an analysis by a Mount Sinai researcher of a phase 2 trial.

13 Feb 2025