Ischemic Stroke News and Research

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Nerinetide shows promise in stroke treatment meta-analysis

The Calgary Stroke Program, a joint University of Calgary and Alberta Health Services initiative at Foothills Medical Centre, has been involved with three papers published this week in The Lancet and Lancet Neurology-the ESCAPE-NEXT trial, the FRONTIER trial, and an individual patient-level meta-analysis across three trials.

19 Feb 2025

Study finds varying cardiovascular risks associated with different hormonal contraceptives

Certain hormonal contraceptives are associated with a higher stroke and heart attack risk, finds a large study from Denmark in The BMJ today that draws on prescription records to give more precise estimates for different products than previous studies.

13 Feb 2025

New method provides accurate measurement of drug permeability across the blood-brain barrier

For decades, scientists across the globe have investigated methods to accurately measure drug permeability across the blood-brain barrier, a compact layer of cells that protect the brain from potentially dangerous substances and microbes.

11 Feb 2025

Tenecteplase injection after clot removal improves stroke recovery

Removing a blood clot from a large brain artery, then injecting the clot-dissolving drug tenecteplase into the artery resulted in stroke survivors being more likely to have better function 90 days after their stroke than those receiving standard clot removal, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2025.

8 Feb 2025

Clot-busting drug alteplase shows promise for stroke treatment up to 24 hours after onset

The clot-dissolving medication, alteplase, improved stroke patients' recovery by more than 50% when given up to 24 hours after the beginning of an ischemic stroke, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2025.

8 Feb 2025

ESCAPE-MeVO trial advances understanding of stroke treatment for medium-sized vessel blockages

University of Calgary's Hotchkiss Brain Institute researchers with the Calgary Stroke Program at Foothills Medical Centre revolutionized treatment for stroke with the ESCAPE Trial, proving that a clot retrieval procedure known as endovascular thrombectomy (EVT) can dramatically improve patient outcomes after an acute ischemic stroke caused by a blockage in a large-sized blood vessel.

7 Feb 2025

Salt substitutes may lower stroke recurrence and death risk

Research indicates that salt substitutes reduce stroke recurrence and death risk, offering a safe dietary intervention for improving stroke patient outcomes.

7 Feb 2025

No extra benefit from mechanical clot removal over medications in some strokes

Removing a clot blocking a medium- or small-sized artery in the brain mechanically is a safe treatment for a common type of stroke; however, it did not lessen disability more than best medical treatment (including clot-busting medication if indicated) alone, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2025.

5 Feb 2025

Rapid blood test could identify brain bleeds from clot-caused strokes

A blood test may rapidly distinguish brain bleeds from clot-caused strokes, even before people with stroke symptoms reach the emergency room, according to a preliminary study to be presented at the American Stroke Association's International Stroke Conference 2025.

30 Jan 2025

Regular dental flossing linked to lower risk of stroke and irregular heartbeats

Flossing your teeth at least once a week may be linked to a lower risk of stroke caused by a blood clot blocking brain blood flow and irregular heartbeats, according to a preliminary study to be presented at the American Stroke Association's International Stroke Conference 2025.

30 Jan 2025

Study reveals abelacimab’s potential to improve anticoagulation safety for AFib patients

Abelacimab, a factor XI inhibitor, demonstrated a 62–69% reduction in major bleeding compared to rivaroxaban in atrial fibrillation patients at moderate-to-high stroke risk, with comparable safety and efficacy. While ischemic stroke rates were slightly higher, they were not statistically significant, warranting further phase 3 trials for confirmation.

23 Jan 2025

New Factor XI inhibitor shows superior safety in treating atrial fibrillation

Patients with atrial fibrillation are typically prescribed an anticoagulant, or blood thinner, to reduce the risk of stroke, but many may discontinue them or never receive a prescription due to concerns of increased risk of bleeding complications.

22 Jan 2025

Researchers create an atlas of health associations for GLP-1 receptor agonists

Insights from a study on GLP-1 receptor agonists reveal benefits for cardiometabolic health, with notable risks for gastrointestinal and musculoskeletal issues.

20 Jan 2025

Stem cell therapy shows promise in restoring brain activity after stroke

Every 40 seconds, someone in the United States has a stroke. For survivors of the most common type of stroke, called an ischemic stroke, only about 5 percent fully recover.

17 Jan 2025

Overcoming limitations of traditional CVD drugs

Announcing a new publication for Acta Materia Medica journal. Cardiovascular diseases (CVDs) pose a significant threat to human health due to the high mortality and morbidity rates. Traditional drugs often have limited efficacy due to inherent constraints, such as low bioavailability and notable side effects.

15 Jan 2025

A comprehensive review of atrial fibrillation

In the U.S., atrial fibrillation (AF), a heart condition that causes an irregular heartbeat in the upper chambers of the heart, affects up to one in three people in their lifetime.

17 Dec 2024

How added sugars and sweetened foods impact the risk of 7 cardiovascular diseases

Researchers examine the risk of seven different types of cardiovascular diseases associated with added and free sugar in foods and beverages.

12 Dec 2024

Study highlights disparities in stroke costs across healthcare services in Latin America

This study assesses acute ischemic stroke costs in Latin America, revealing treatment variations and economic challenges that impact healthcare accessibility.

11 Dec 2024

Women skip post-stroke medications more often than men, study reveals

Women, especially Mexican Americans, are more likely than men to skip critical post-stroke medications, highlighting the need for targeted interventions to improve adherence and reduce stroke recurrence.

9 Dec 2024

Study finds divergent relationship between different sugar sources and cardiovascular disease risk

A little of what you fancy does you good… unless it's a fizzy drink. Scientists studying the impact of sugar on the risk of cardiovascular disease have found that eating too much added sugar increases your risk of stroke or aneurysm, but eating a few treats is associated with a lower risk of cardiovascular diseases.