Phosphorylation News and Research

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The Proteoform Puzzle: Unlocking the Next Frontier

In the interview, Lloyd M. Smith discusses proteoforms, an area of research worthy of the next Human Genome Project.

From Pittcon 10 Jul 2025

Energy waves on cancer cell surfaces linked to tumor growth and aggressiveness

In a bid to better understand how cancer cells power their explosive growth and spread, scientists at Johns Hopkins Medicine say they have shed new light on the location and function of power-generating waves on the covering, or membrane, of these cells.

9 Jul 2025

Study uncovers the molecular evolutionary strategies of the OxPhos system

Mitochondria are the body's "energy factories," and their proper function is essential for life. Inside mitochondria, a set of complexes called the oxidative phosphorylation (OxPhos) system acts like a biochemical assembly line, transforming oxygen and nutrients into usable energy.

4 Jul 2025

Aromatic benzaldehyde inhibits growth of therapy-resistant pancreatic cancer

During therapy, some cancer cells evolve to escape elimination. Newer anticancer drugs that can overcome this resistance are necessary.

2 Jul 2025

Targeting mitochondrial dynamics to combat breast cancer metastasis

Breast cancer, particularly triple-negative breast cancer (TNBC), remains a leading cause of cancer-related mortality due to its aggressive nature and limited therapeutic targets.

27 Jun 2025

FAM111B identified as a key driver of glioma progression and therapeutic target

Gliomas are among the deadliest brain tumors, with limited treatment options and poor survival rates. Scientists from China identified FAM111B, a DNA-repair-associated protein, as a key driver of glioma progression.

27 Jun 2025

Study explores how a familiar spice tackles the toughest cancer cells

Researchers found that clinically achievable doses of curcumin, the active compound in turmeric, target and suppress colorectal cancer stem-like cells, especially in early adenomas. Curcumin shifts these cells toward differentiation, delays tumor growth in mice, and may offer a safe preventive strategy.

27 Jun 2025

Next generation CAR-T cells push the boundaries of lymphoma treatment

CAR-T cells, which are genetically programmed to specifically recognize and kill target cells, have altered the therapeutic landscape of lymphoma.

23 Jun 2025

Epigenetic dysregulation drives hepatocellular carcinoma development

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide.

19 Jun 2025

Study uncovers molecular mechanism behind 'ticking' of the circadian clock in cyanobacteria

Researchers from the Institute for Molecular Science (IMS)/SOKENDAI and Kyushu University have uncovered the molecular mechanism that drives the "ticking" of the circadian clock in cyanobacteria.

13 Jun 2025

Chronic hyponatremia causes anxiety-like behaviors by disrupting brain chemistry

Hyponatremia, or low blood sodium concentration, is typically viewed as a symptomless condition-until recently.

12 Jun 2025

Study aims to demystify the immune toxicity triggered by osimertinib-ICI co-treatment

Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases and remains a leading cause of cancer mortality worldwide.

6 Jun 2025

Study uncovers how HSV-1 disables the brain's antiviral defense

Infections caused by herpes simplex virus type 1 (HSV-1) can lead to HSV-1 encephalitis-a rare but deadly condition that inflames the brain.

3 Jun 2025

What drives insulin resistance? Proteomics reveals key pathways in human skeletal muscle

Identifying proteomic signatures of insulin resistance in fasting muscle offers insights for personalized type 2 diabetes therapies based on molecular profiles.

30 May 2025

High fat diet disrupts metabolism and increases disease risk

Consuming a high-fat diet can lead to a variety of health problems - not only weight gain but also an increased risk of diabetes and other chronic diseases.

28 May 2025

Rethinking the mitochondrial theory of aging

The human genome is broadly classified into the genome residing in the cell nucleus (nuclear DNA) and the genome residing in the mitochondria (mitochondrial DNA: mtDNA). Mitochondria are cell organelles that produce energy essential for life activities through oxidative phosphorylation (mitochondrial respiration), and mtDNA encodes a set of genes required for mitochondrial respiration.

27 May 2025

Natural compounds from Brazilian plants show promise against stomach cancer

A new review was published in Volume 12 of Oncoscience on May 8, 2025, titled "The chemopreventive effects of native Brazilian plants on stomach cancer: A review of the last 25 years."

22 May 2025

Cysteine depletion triggers rapid weight loss in mice

Mice genetically engineered to lack the ability to make the amino acid cysteine, and fed a cysteine-free diet, lost 30 percent of their body weight in just one week, a new study shows.

22 May 2025

Novel Alzheimer's therapy shows low risk of severe side effects

The Food and Drug Administration's approval in 2023 of lecanemab - a novel Alzheimer's therapy shown in clinical trials to modestly slow disease progression - was met with enthusiasm by many in the field as it represented the first medication of its kind able to influence the disease.

12 May 2025

Natural compound fisetin protects blood vessels from hardening

A new research paper was published in Aging (Aging-US) Volume 17, Issue 4, on April 2, 2025, titled "Fisetin ameliorates vascular smooth muscle cell calcification via DUSP1-dependent p38 MAPK inhibition."

6 May 2025