Biochemistry News and Research

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New technique can upregulate specific genes without permanently altering the genome

By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical "off switches" that silence them.

6 Mar 2022

Cell-hobbling fibrils found across diverse neurodegenerative diseases

Take a cell-deep tour of a brain afflicted with Alzheimer's disease, and you will find minuscule clumps of protein that seem suspicious. Ever since the 1980s, when neuroscientists began identifying these protein tangles, researchers have discovered that other brain diseases have their own tangled-protein signatures.

4 Mar 2022

Study may pave the way for better multiple sclerosis drugs

Investigators from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center have discovered how a drug for multiple sclerosis interacts with its targets, a finding that may pave the way for better treatments.

4 Mar 2022

COVID-19 and the life sciences; what have we learned and where are we going?

News-Medical attended the 2022 SLAS press briefing where Peter Simpson, Michael Girardi, and Simon Meffan-Main gave their thoughts on the life sciences sector post-COVID-19.

From Society for Laboratory Automation and Screening (SLAS) 4 Mar 2022

Study finds how genetic baggage can accumulate in the genomes of normal and mutant animals

You are probably familiar with the term that some people carry "a lot of extra baggage." Usually that term refers to that person's emotional history, but in genetics and our genomes, "extra baggage" can also describe the transposons lurking in our genomes, a historical record of our genomes surviving traumatic invasions during evolution.

4 Mar 2022

Texas A&M team continues research on the potential cure for Menkes disease

A life-saving cure solution for Menkes Disease, a copper deficiency in young children, is at the center of a licensing agreement by the The Texas A&M University System, through the Intellectual Property and Commercialization office of Texas A&M AgriLife Research, and a California-based biopharmaceutical company, Engrail Therapeutics.

3 Mar 2022

Novel mechanism that connects circadian rhythm and muscle repair discovered

Northwestern Medicine investigators have discovered a novel mechanism that connects circadian rhythm-controlled cellular metabolism and regeneration with muscle repair after injury, according to recent findings published in the journal Genes and Development.

28 Feb 2022

Scientists uncover new role of chromatin-modulatory enzyme during cancer development

Researchers at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center have uncovered a new role of a chromatin-modulatory enzyme, termed EZH2, during cancer development.

24 Feb 2022

Prenatal phthalate exposure may impact infants' growth and health

Phthalates are endocrine disrupting chemicals that are used in plastics and as food additives. A recent study in Environmental Toxicology and Chemistry examined whether prenatal exposure to phthalates in maternal and cord blood affects birth outcomes in infants.

24 Feb 2022

Researchers unravel essential final steps in the production of mRNA

Proteins need to interact in a complex manner for a so-called "messenger RNA" (mRNA) to be created in human cells from a precursor molecule. mRNA provides a blueprint for proteins; the first vaccines against the coronavirus are also based on mRNAs.

21 Feb 2022

Structure of protein that can pump toxic molecules out of bacterial cells revealed

MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. coli, are believed to help bacteria become resistant to multiple antibiotics.

18 Feb 2022

New research shines light on mysterious dynamics that define the interplay between nerves and muscle

New research co-led by a University of Ottawa Faculty of Medicine professor is shedding light on some of the mysterious dynamics that define the interplay between nerves and muscle.

17 Feb 2022

Penn State researchers receive $3.9 million to study the impact of COVID-19 on pregnancy

The Pennsylvania Department of Health has awarded Penn State College of Medicine $3.9 million through May 2025 to study the impact COVID-19 has on pregnancy.

17 Feb 2022

Smartphone-based COVID-19 detection system

In this interview, we speak to Professor Michael Mahan about his latest research which aimed to bring low-cost, state-of-the-art diagnostics to resource-limited settings.

17 Feb 2022

Hyperactive microglia can have a protective effect in the course of neurodegenerative diseases

Findings by researchers from Germany support the view that hyperactive immune cells in the brain can have a protective effect in the course of neurodegenerative diseases.

14 Feb 2022

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.

14 Feb 2022

Cells self-organize to generate forces that model the shapes of tissues

A team from the UNIGE has demonstrated that cells self-organise to generate forces that model the shapes of our tissues.

12 Feb 2022

Scientists discover a new class of potential drug targets for neurodegenerative diseases

Oregon State University scientists have discovered a new class of potential drug targets for people suffering from neurodegenerative conditions such as Alzheimer's, Parkinson's and Lou Gehrig's disease.

10 Feb 2022

Study provides new understanding of caffeine's protective effects on the cardiovascular system

Scientists have a new understanding of the protective effects of caffeine on the cardiovascular system. While its stimulant effects have long been characterized, a team of Canadian researchers have discovered how caffeine interacts with key cellular factors to remove cholesterol from the bloodstream.

10 Feb 2022

Researchers reveal new therapeutic way to block oncogenic RAS mutants

As a 10-year journey comes to fruition, MUSC Hollings Cancer Center researcher John O'Bryan, Ph.D., and colleagues have demonstrated a new therapeutic way to block a protein that is frequently mutated in cancers.

9 Feb 2022

Biochemistry News and Research

New technique can upregulate specific genes without permanently altering the genome

Cell-hobbling fibrils found across diverse neurodegenerative diseases

Study may pave the way for better multiple sclerosis drugs

COVID-19 and the life sciences; what have we learned and where are we going?

Study finds how genetic baggage can accumulate in the genomes of normal and mutant animals

Texas A&M team continues research on the potential cure for Menkes disease

Novel mechanism that connects circadian rhythm and muscle repair discovered

Scientists uncover new role of chromatin-modulatory enzyme during cancer development

Prenatal phthalate exposure may impact infants' growth and health

Researchers unravel essential final steps in the production of mRNA

Structure of protein that can pump toxic molecules out of bacterial cells revealed

New research shines light on mysterious dynamics that define the interplay between nerves and muscle

Penn State researchers receive $3.9 million to study the impact of COVID-19 on pregnancy

Smartphone-based COVID-19 detection system

Hyperactive microglia can have a protective effect in the course of neurodegenerative diseases

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Cells self-organize to generate forces that model the shapes of tissues

Scientists discover a new class of potential drug targets for neurodegenerative diseases

Study provides new understanding of caffeine's protective effects on the cardiovascular system

Researchers reveal new therapeutic way to block oncogenic RAS mutants

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