Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

Increased risk of virologic failure associated with NNRTI-based regimens in HIV-1 drug resistance mutations

An analysis of data from 10 studies indicates that the presence of low frequency (also called "minority") human immunodeficiency virus type 1 (HIV-1) drug resistance mutations, particularly those involving nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance, are significantly associated with an increased risk of first-line antiretroviral treatment failure, according to an article in the April 6 issue of JAMA.

6 Apr 2011

Abbott and Enanta's ABT-450/r Phase 2 study results against HCV presented at EASL meeting

Abbott and Enanta Pharmaceuticals today announced 12-week results from a Phase 2 study of ABT-450/r, an investigational, oral protease inhibitor being developed for the treatment of hepatitis C infection.

4 Apr 2011

Optimer study highlights economic burden of acute and recurrent CDI in hospital patients

Optimer Pharmaceuticals, Inc. announced today the presentation of information from insurance claims and survey databases highlighting the unmet need for targeted therapies to treat subpopulations at high risk of recurrence of Clostridium difficile infection.

4 Apr 2011

HIV uses base excision repair pathway to insert DNA into host-cell genome

The human immunodeficiency virus (HIV), the cause of AIDS, makes use of the base excision repair pathway when inserting its DNA into the host-cell genome, according to a new study led by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. Crippling the repair pathway prevents the virus from completing this critical step in the retrovirus's life cycle.

25 Mar 2011

CSL Behring presents Hizentra study data against PI at AAAAI meeting

Data presented by CSL Behring today suggest that treatment with higher dose Hizentra correlates with reduced risk of infection and missed school or work among patients with primary immunodeficiencies.

22 Mar 2011

Highmark forces patients with PIDD to switch over to specific IgG therapy

Beginning April 1, Highmark Blue Cross Blue Shield will force their insured patients with primary immunodeficiency diseases and other rare disorders to switch their prescription to a single brand of immunoglobulin, regardless of their current IgG therapy.

17 Mar 2011

Nationwide observance raises awareness about HIV/AIDS spread in women

National Women and Girls AIDS Awareness Day, a nationwide observance that raises awareness and promotes action in the fight against HIV/AIDS, took place on March 10.

17 Mar 2011

Research highlights new parameters for HIV study

A research article co-authored by Brenna Anderson, MD, director of Reproductive Infectious Diseases Consultation in the Division of Maternal-Fetal Medicine at Women & Infants Hospital of Rhode Island, was included in the recently published special issue of the American Journal of Reproductive Immunology.

17 Mar 2011

Elite controllers' T cells resist HIV-1 infection by selective upregulation of protein p21

In the years since the AIDS epidemic began, it has become clear that there is substantial variation in the way that individuals respond to HIV infection. Although most progress quickly from initial infection to immunodeficiency, a small subset survive for long periods without developing symptoms.

16 Mar 2011

Discovery: VPS4A enzyme plays a key role in release of HIV particles

Human Immunodeficiency Virus - which causes AIDS - invades human immune cells and causes them to produce new copies of the virus, which can then infect new cells.

11 Mar 2011

Caltech students receive Lemelson-MIT Prize for innovative disease diagnostic technology works

California Institute of Technology graduate student Guoan Zheng is the recipient of the 2011 $30,000 Lemelson-MIT Caltech Student Prize.

10 Mar 2011

$100 million in grants for medical research announced

More than $100 million in grants was announced this Tuesday for an ambitious research project that will try to find what makes cancer so hard to beat. This project received $21.3 million from the National Health and Medical Research Council grants.

8 Mar 2011

iPrEx update, bone mineral density study highlighted at day three of 18th CROI

The 18th Conference on Retroviruses and Opportunistic Infections is being held at the Hynes Convention Center in Boston from February 27 through March 2. Day three of this major HIV/AIDS research conference included the following selected presentations from scientists supported by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

5 Mar 2011

ATS releases new report detailing emerging trends in HIV-linked pulmonary disease management

The American Thoracic Society has released a new report detailing recent global changes in the management of human immunodeficiency virus-associated pulmonary disease.

4 Mar 2011

Vertex announces positive interim results from telaprevir Phase 2 study in patients with HCV, HIV

Vertex Pharmaceuticals Incorporated announced today interim results from an ongoing, two-part, Phase 2 study evaluating telaprevir in combination with pegylated-interferon and ribavirin compared to pegylated-interferon and ribavirin alone in people who are infected with both genotype 1 hepatitis C virus and human immunodeficiency virus, also known as HCV-HIV co-infection.

3 Mar 2011

Calypte Biomedical completes new Aware HIV-1/2 oral fluid rapid test internal studies

Calypte Biomedical Corporation, a developer, manufacturer and marketer of HIV diagnostic tests, today announced successful completion of internal studies of its new Aware HIV-1/2 oral fluid rapid test for the US and international markets.

2 Mar 2011

New insight into HIV/AIDS

A paper published in the March 2011 print edition of the Journal of Clinical Investigation offers new insight into what prompts immunity to AIDS in sooty mangabeys, a natural host African monkey species.

2 Mar 2011

HIV women take photos to document their lives

A picture may be worth a thousand words, but for women living with human immunodeficiency virus, the virus that causes AIDS, a picture can help them deal with the challenges of living with the virus.

1 Mar 2011

New research may shed light on how HIV virus reactivates from latency

New research enhances the current knowledge of how human immunodeficiency virus type-1, which causes AIDS, controls the cell cycle of cells that it infects. The new findings may shed light on how the virus reactivates after entering a dormant state, called latency.

28 Feb 2011

Vaccine lawsuit rejected by Supreme Court

The U.S. Supreme Court ruled on Tuesday against the parents of Hannah Bruesewitz, 18, who suffered seizures and permanent brain damage after receiving a diptheria-tetanus-pertussis (DTP) vaccine in 1993. The Bruesewitz family had sued Wyeth who was then the parent company of the maker of the DTP vaccine that Hannah received as an infant.

27 Feb 2011

Immunodeficiency News and Research

Further Reading

Increased risk of virologic failure associated with NNRTI-based regimens in HIV-1 drug resistance mutations

Abbott and Enanta's ABT-450/r Phase 2 study results against HCV presented at EASL meeting

Optimer study highlights economic burden of acute and recurrent CDI in hospital patients

HIV uses base excision repair pathway to insert DNA into host-cell genome

CSL Behring presents Hizentra study data against PI at AAAAI meeting

Highmark forces patients with PIDD to switch over to specific IgG therapy

Nationwide observance raises awareness about HIV/AIDS spread in women

Research highlights new parameters for HIV study

Elite controllers' T cells resist HIV-1 infection by selective upregulation of protein p21

Discovery: VPS4A enzyme plays a key role in release of HIV particles

Caltech students receive Lemelson-MIT Prize for innovative disease diagnostic technology works

$100 million in grants for medical research announced

iPrEx update, bone mineral density study highlighted at day three of 18th CROI

ATS releases new report detailing emerging trends in HIV-linked pulmonary disease management

Vertex announces positive interim results from telaprevir Phase 2 study in patients with HCV, HIV

Calypte Biomedical completes new Aware HIV-1/2 oral fluid rapid test internal studies

New insight into HIV/AIDS

HIV women take photos to document their lives

New research may shed light on how HIV virus reactivates from latency

Vaccine lawsuit rejected by Supreme Court

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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