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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Researchers establish link between bovine leukemia virus and human breast cancer

A new study by University of California, Berkeley, researchers establishes for the first time a link between infection with the bovine leukemia virus and human breast cancer.

16 Sep 2015

Benitec Biopharma initiates new site for ongoing Phase 1/2a TT-034 trial for hepatitis C

Benitec Biopharma Limited, a clinical-stage biotechnology company developing innovative therapeutics based on its gene-silencing technology, DNA-directed RNA interference (ddRNAi), is pleased to announce it has initiated a new site for its ongoing Phase 1/2a TT-034 trial at the Methodist Health System Clinical Research Institute in Dallas, Texas.

16 Sep 2015

New Penn Medicine research shows vital role of Esrp1 and Esrp2 genes in skin, organ development

Knocking out one or both crucial regulatory genes caused cleft lip, skin barrier defects, and a host of other developmental problems in mice, according to new research from the Perelman School of Medicine at the University of Pennsylvania, hinting that abnormalities in these molecular pathways could underlie many birth defects that are presently not well understood. The two closely related regulatory genes are active in the normal development of mammals and govern how RNAs produced from the genes are joined to make final versions of the encoded protein, a process called alternative splicing.

16 Sep 2015

Scientists find how cells adapt to overcome cancer drugs

CANCER RESEARCH UK scientists have found how cells adapt to overcome cancer drugs designed to interfere with their genetic controls, according to a study published today (Wednesday) in Epigenetics and Chromatin.

16 Sep 2015

Researchers use new software tool to identify genetic overlaps between palmitoleic acid and Crohn's disease

Some research has suggested that omega-3 fatty acids, abundant in fish oils, can relieve inflammation in Crohn's disease. But a new study using software developed by Duke scientists hints that we should be paying closer attention to what the other omegas -- namely, omega-6 and omega-7 -- are doing to improve or worsen the disease.

16 Sep 2015

UCSF receives $5 million grant to create online database on all types of cancer

UC San Francisco has received a National Cancer Institute grant of $5 million over the next five years to lead a massive effort to integrate the data from all experimental models across all types of cancer.

16 Sep 2015

Using integrated molecular pathology to manage incidental pancreatic cysts: an interview with Dr Ananya Das

Pancreatic cystic neoplasms, or PCNs, are a subset of all pancreatic cysts that are found on the pancreas. PCNs are neoplastic cysts that span a biological spectrum from benign to malignant.

15 Sep 2015

Study reveals how leukemia cells evade deadly effects of BRD4 inhibitors

BRD4 inhibitors are among the most promising new agents in cancer therapy that are currently evaluated in clinical trials.

15 Sep 2015

$Whole-genome sequencing identifies EN1 gene as determinant of bone mineral density, fracture$

Whole-genome sequencing identifies EN1 gene as determinant of bone mineral density, fracture

Using extensive genetic data compiled by the UK10K project, an international team of researchers led by Dr. Brent Richards of the Lady Davis Institute at the Jewish General Hospital has identified a genetic variant near the gene EN1 as having the strongest effect on bone mineral density (BMD) and fracture identified to date.

15 Sep 2015

Combining epigenetic drugs with immunotherapies may provide additional clinical benefit to cancer patients

Recent data suggest that epigenetic therapies are likely to provide additional clinical benefit to cancer patients when rationally combined with immunotherapeutic drugs, according to a review published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

15 Sep 2015

Novel long non-coding RNA has potential to stymie growth of tumor cells in colon cancer

Genetics researchers from Case Western Reserve School of Medicine have identified a novel long non-coding RNA (lncRNA), dubbed DACOR1, that has the potential to stymie the growth of tumor cells in the second-most deadly form of cancer in the U.S. — colorectal cancer.

14 Sep 2015

UNC scientists create smarter immune cells to treat Parkinson's disease

As a potential treatment for Parkinson's disease, scientists at the University of North Carolina at Chapel Hill have created smarter immune cells that produce and deliver a healing protein to the brain while also teaching neurons to begin making the protein for themselves.

14 Sep 2015

NanoString announces key initiatives to expand market for nCounter Analysis System, related product portfolio

At a meeting with analysts and investors today, members of the senior management team of NanoString Technologies, Inc., a provider of life science tools for translational research and molecular diagnostic products, plan to unveil the company’s strategic roadmap to drive continued growth and expand the market for its nCounter Analysis System and the related product portfolio.

From NanoString Technologies 14 Sep 2015

Penn Medicine researchers show that DNA editing errors can lead to cancer

Sometimes when the immune system makes small mistakes, the body amplifies its response in a big way: Editing errors in the DNA of developing T and B cells can cause blood cancers. Now, researchers from the Perelman School of Medicine, University of Pennsylvania have shown that when the enzyme key to cutting and pasting segments of DNA hits so-called "off-target" spots on a chromosome, the development of immune cells can lead to cancer in animal models.

11 Sep 2015

NYU's Jin Kim Montclare develops dual-delivery system to potentially treat multi-drug resistant cancer cells

The National Science Foundation recently funded research aimed at developing an engineered protein-lipid system that simultaneously delivers genes and drugs for the potential treatment of multi-drug resistant cancer cells. The dual-delivery system could also apply to diabetes and other conditions requiring a variety of therapeutic approaches.

11 Sep 2015

New AGA guideline recommends colorectal cancer patients to undergo tumor test for Lynch syndrome

All colorectal cancer patients should undergo tumor testing to see if they carry Lynch syndrome, the most common inherited cause of colorectal cancer, according to a new guideline published in Gastroenterology, the official journal of the American Gastroenterological Association.

11 Sep 2015

Scientists elucidate genetic interaction that may prove key to development, progression of glaucoma

Scientists at the University of California, San Diego School of Medicine have elucidated a genetic interaction that may prove key to the development and progression of glaucoma, a blinding neurodegenerative disease that affects tens of millions of people worldwide and is a leading cause of irreversible blindness.

11 Sep 2015

New research shows direct evidence of greater mitochondrial damage in Gulf War veterans

One in four Gulf War veterans suffers from Gulf War Illness (GWI). The condition is characterized by unexplainable chronic fatigue, muscle pain and cognitive dysfunction and may be associated with exposure to chemicals, many identified as genotoxins, during deployment.

11 Sep 2015

Hastings Center receives NSF grant for ethical analysis of next-generation prenatal genetic tests

Prenatal testing is changing dramatically. With greatly expanded low-cost genetic tests - some as simple as a maternal blood test - prospective parents will soon be able to learn far more, far earlier, than ever before about their fetuses' medical conditions and risks, and some nonmedical traits.

11 Sep 2015

New DNA analysis may guide personalized management of hepatocellular carcinoma

Detection of small fragments of tumor DNA, known as circulating tumor DNA, in a patient's pre-surgery serum samples predicts early recurrence of hepatocellular carcinoma and may guide treatment, according to a study published in Cellular and Molecular Gastroenterology and Hepatology, the basic and translational science journal of the American Gastroenterological Association.

10 Sep 2015

DNA News and Research

Further Reading

Researchers establish link between bovine leukemia virus and human breast cancer

Benitec Biopharma initiates new site for ongoing Phase 1/2a TT-034 trial for hepatitis C

New Penn Medicine research shows vital role of Esrp1 and Esrp2 genes in skin, organ development

Scientists find how cells adapt to overcome cancer drugs

Researchers use new software tool to identify genetic overlaps between palmitoleic acid and Crohn's disease

UCSF receives $5 million grant to create online database on all types of cancer

Using integrated molecular pathology to manage incidental pancreatic cysts: an interview with Dr Ananya Das

Study reveals how leukemia cells evade deadly effects of BRD4 inhibitors

Whole-genome sequencing identifies EN1 gene as determinant of bone mineral density, fracture

Combining epigenetic drugs with immunotherapies may provide additional clinical benefit to cancer patients

Novel long non-coding RNA has potential to stymie growth of tumor cells in colon cancer

UNC scientists create smarter immune cells to treat Parkinson's disease

NanoString announces key initiatives to expand market for nCounter Analysis System, related product portfolio

Penn Medicine researchers show that DNA editing errors can lead to cancer

NYU's Jin Kim Montclare develops dual-delivery system to potentially treat multi-drug resistant cancer cells

New AGA guideline recommends colorectal cancer patients to undergo tumor test for Lynch syndrome

Scientists elucidate genetic interaction that may prove key to development, progression of glaucoma

New research shows direct evidence of greater mitochondrial damage in Gulf War veterans

Hastings Center receives NSF grant for ethical analysis of next-generation prenatal genetic tests

New DNA analysis may guide personalized management of hepatocellular carcinoma

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