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Novel therapy advances to clinical trial for the treatment of glioblastoma

A novel therapy studied at the Medical College of Wisconsin (MCW) Cancer Center has led to a clinical trial for the treatment of glioblastoma, a rare and aggressive form of brain cancer, yet the most common primary brain tumor in adults.

10 Apr 2022

B-cells have significant differences in women with postpartum depression, finds study

A study published in Molecular Psychiatry is the first to look at multiple levels of biology within women with postpartum depression (PPD) to see how women with the condition differ from those without it.

10 Apr 2022

Researchers seek to understand how microbes in the GI tract help people resist pathogens

Published in Nature Communications, research from the University of Minnesota and Mayo Clinic sought to understand how microbial communities help people resist pathogens.

8 Apr 2022

New delivery method enhances the "attack power" of CAR T cells against tumors

One cutting-edge cancer treatment exciting researchers today involves collecting and reprogramming a patient's T cells – a special set of immune cells – then putting them back into the body ready to detect and destroy cancerous cells.

8 Apr 2022

UNSW research improves fundamental understanding of the mechanism behind sickle cell disease

UNSW researchers have used CRISPR gene editing – a type of 'molecular scissors' – to understand how deletions in one area of the genome can affect the expression of nearby genes.

8 Apr 2022

Combination immunotherapy reverses resistance to PD-1 inhibitors in patients with advanced melanoma

Patients with advanced melanoma whose cancer does not respond to treatment with widely used immunotherapy drugs known as PD-1 inhibitors are often switched to treatment with a second type of immunotherapy drug – a CTLA-4 inhibitor such as the drug ipilimumab.

8 Apr 2022

Computational network science approach reveals new mechanisms for coronaviruses infections

A group of bat viruses related to SARS-CoV-2 can also infect human cells but uses a different and unknown entryway.

8 Apr 2022

City of Hope's late-breaking clinical trial data to be presented at AACR

Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, will present late-breaking and clinical trial findings at this year's American Association for Cancer Research Annual Meeting, which begins today.

8 Apr 2022

Study defines nonredundant role for T cell-derived interleukin-22 in antibacterial defense of colonic crypts

Intestinal epithelial cells line the inner wall of the gut, creating a barrier to dangerous bacteria like enteropathogenic E. coli that seek to attach and efface that barrier, causing diarrhea.

8 Apr 2022

Researchers discover new mechanisms for bone loss in gum disease

Tokyo University of Agriculture and Technology researchers reported on a new discovery regarding the mechanisms for bone loss in gum disease (periodontitis). They found that double stranded RNA molecules can activate the immune system response that leads to deterioration of bone.

8 Apr 2022

Substantial SARS-CoV-2 infection in perivascular cells of inflamed blood vessels

A new study demonstrated that vascular inflammation leads to heightened SARS-CoV-2 infection in perivascular cells.

8 Apr 2022

Depressive disorders are associated with general increase in the deformability of immune cells

A recent study by the TU Dresden and the University of Zurich in cooperation with the Max Planck Institute for the Science of Light establishes for the first time a link between depressive disorders and mechanical characteristics of all major blood cell types.

8 Apr 2022

SARS-CoV-2 Omicron variant spike-specific unique cluster of differentiation cells

A new study presented a safe and efficient multi-epitope SARS-CoV-2 vaccine construct against SARS-CoV-2 variants, including Omicron.

8 Apr 2022

SARS-CoV-2 Delta-Omicron recombinant identified in a transplant patient treated with Sotrovimab

Researchers described a case of co-infection with SARS-CoV-2 variants of concern, Delta and Omicron.

8 Apr 2022

Study characterizes SARS-CoV-2 spike-specific cluster of differentiation 4+ T-cell response

In a new study, researchers characterized over 100 SARS-CoV-2-specific CD4+ T-cell epitopes.

8 Apr 2022

Role of natural immunity to SARS-CoV-2 on post-vaccination antibody responses in staff and residents of long-term care facilities

A new study collected and analyzed sera from the staff at a local long-term care facility from August to December 2020, where an outbreak occurred in September 2020.

8 Apr 2022

Improved seroprevalence and antibody response after third COVID-19 vaccination

Researchers evaluated the immunogenicity of a third COVID-19 vaccination in antibody deficient subjects.

8 Apr 2022

Neutralization potency against the Omicron variant of naturally expressed MBC-derived IgG antibodies from vaccinated individuals

Researchers have shown how the Omicron variant of the SARS-CoV-2 successfully evaded a large fraction of antibodies derived from memory B cells, giving rise to a reduced, but incomplete immune escape.

8 Apr 2022

Researchers develop new method to ‘time jump’ skin cells by 30 years

Research from the Babraham Institute has developed a method to 'time jump' human skin cells by 30 years, turning back the aging clock for cells without losing their specialized function.

8 Apr 2022

Large-scale study sheds more light on the genetic basis of schizophrenia

What is the role of genetics in schizophrenia? To address this question, an international group of researchers led by Charité – Universitätsmedizin Berlin and Cardiff University developed and conducted the largest-ever genetic study on schizophrenia.

7 Apr 2022

B Cell News and Research

Novel therapy advances to clinical trial for the treatment of glioblastoma

B-cells have significant differences in women with postpartum depression, finds study

Researchers seek to understand how microbes in the GI tract help people resist pathogens

New delivery method enhances the "attack power" of CAR T cells against tumors

UNSW research improves fundamental understanding of the mechanism behind sickle cell disease

Combination immunotherapy reverses resistance to PD-1 inhibitors in patients with advanced melanoma

Computational network science approach reveals new mechanisms for coronaviruses infections

City of Hope's late-breaking clinical trial data to be presented at AACR

Study defines nonredundant role for T cell-derived interleukin-22 in antibacterial defense of colonic crypts

Researchers discover new mechanisms for bone loss in gum disease

Substantial SARS-CoV-2 infection in perivascular cells of inflamed blood vessels

Depressive disorders are associated with general increase in the deformability of immune cells

SARS-CoV-2 Omicron variant spike-specific unique cluster of differentiation cells

SARS-CoV-2 Delta-Omicron recombinant identified in a transplant patient treated with Sotrovimab

Study characterizes SARS-CoV-2 spike-specific cluster of differentiation 4+ T-cell response

Role of natural immunity to SARS-CoV-2 on post-vaccination antibody responses in staff and residents of long-term care facilities

Improved seroprevalence and antibody response after third COVID-19 vaccination

Neutralization potency against the Omicron variant of naturally expressed MBC-derived IgG antibodies from vaccinated individuals

Researchers develop new method to ‘time jump’ skin cells by 30 years

Large-scale study sheds more light on the genetic basis of schizophrenia

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