Antibody News and Research

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An antibody is a blood protein that is produced in response to and counteracts an antigen. Antibodies are produced in response to disease and help the body fight against the particular disease. In this way, antibodies help the body develop an immunity to disease.

Researchers develop universal influenza vaccine for animals

A University of Maryland-led science team has developed a universal influenza vaccine for animals that may help prevent or delay another human flu pandemic.

14 Dec 2008

Early-stage breast cancer patients with HER2 positive tumors at increased risk of recurrence

Early-stage breast cancer patients with HER2 positive tumors one centimeter or smaller are at significant risk of recurrence of their disease, compared to those with early-stage disease who do not express the aggressive protein, according to a study led by researchers at The University of Texas M. D. Anderson Cancer Center.

14 Dec 2008

FDA to review Barr Pharmaceutical's BLA for adenovirus type 4 and 7 live oral vaccines

Barr Pharmaceuticals, Inc. has announced that the U.S. Food and Drug Administration (FDA) has accepted for review Duramed Pharmaceuticals, Inc.'s Adenovirus Types 4 and 7 Live Oral Vaccines Biologics License Application (BLA).

14 Dec 2008

Researchers identify how key mutations occur in human lymphomas

Researchers at the Keck School of Medicine of the University of Southern California (USC) have explained how certain key mutations occur in human lymphomas - a process that has, until now, remained a mystery.

12 Dec 2008

Novavax announces positive results in trial of seasonal influenza VLP (trivalent) vaccine candidate

Novavax, Inc. has announced favorable results from a Phase IIa human clinical trial of its seasonal influenza VLP (trivalent) vaccine candidate.

12 Dec 2008

Enzyme that mutates antibodies also targets cancer-causing gene

The human immune system is in a perpetual state of self-experimentation. It expertly mutates and shuffles the DNA of its own cells to evolve new defenses against the vast array of microbes that try to invade our bodies.

12 Dec 2008

Enzyme that mutates antibodies also targets a cancer-causing oncogene

Rockefeller University scientists have discovered that the same enzyme that enables the immune system's defensive creativity is also responsible for a particular genetic malfunction - a translocation of one piece of DNA to the wrong chromosome - that causes Burkitt's lymphoma.

12 Dec 2008

Vaxfectin-formulated H5N1 pandemic influenza achieves T-cell responses and cross-clade reactivity in humans

Vical Incorporated has announced that the company's Vaxfectin-formulated H5N1 pandemic influenza DNA vaccines induced T-cell responses against a matching strain of influenza virus and demonstrated cross-clade antibody responses against a different strain in a Phase 1 clinical trial.

11 Dec 2008

Mathematical models of adaptive immunity

More than five million people die every year from infectious diseases, despite the availability of numerous antibiotics and vaccines. The discovery of penicillin to treat bacterial infections, along with the development of vaccines for previously incurable virus diseases such as polio and smallpox, achieved great reductions in mortality during the mid-20th century.

11 Dec 2008

An enzyme that mutates antibodies also targets a cancer-causing oncogene

11 Dec 2008

Blocking immune receptor molecule improves response to HIV-like virus, prolongs survival in monkeys

By blocking PD-1 (programmed death-1), an immune receptor molecule known to inhibit the immune response to chronic viral infections, scientists have safely and significantly reduced the plasma viral load and also prolonged survival of rhesus macaque monkeys severely infected with simian immunodeficiency virus (SIV), the nonhuman primate version of human immunodeficiency virus (HIV).

10 Dec 2008

Xencor presents data on anti-CD19 and anti-CD40 antibodies

Xencor, Inc. presented results Sunday at the 50th Annual Meeting of the American Society of Hematology from pre-clinical studies evaluating XmAb 5574, a monoclonal antibody engineered using Xencor's XmAb Fc technologies that targets the antigen CD19.

10 Dec 2008

DNA vaccine for SARS achieves neutralizing responses in first U.S. human trial

Vical Incorporated (NASDAQ:VICL) today announced that results from a Phase I clinical trial of a DNA vaccine for severe acute respiratory syndrome (SARS), conducted by the National Institutes of Health (NIH) and published in the November 25 issue of Vaccine(1), demonstrated that the vaccine was well-tolerated, and induced neutralizing antibody responses in 80% of the vaccinees and T-cell immune responses in all vaccinees.

10 Dec 2008

Vaccine against malaria could be ready in 5 years

Malaria kills more than one million people every year so the news that an effective vaccine could be available within five years is more than welcome.

9 Dec 2008

Statins do not interfere with Rituximab treatment for lymphomas

Statins, drugs widely prescribed to lower cholesterol, do not interfere with a commonly used medication to treat lymphomas, according to a Mayo Clinic study presented at the 50th Annual Meeting of the American Society of Hematology in San Francisco.

8 Dec 2008

Half-dose vaccination in healthy young individuals may be effective in times of vaccine shortage

Individuals younger than 50 who have been previously vaccinated do not appear to have a substantially different immune response to a half-dose of influenza vaccine than to a full dose, according to a report in the December 8/22 issue of Archives of Internal Medicine.

8 Dec 2008

Discovery of protein that may cause breast cancer to spread

In an important finding published online in Developmental Cell , researchers at Albert Einstein College of Medicine of Yeshiva University, along with collaborators at Massachusetts Institute of Technology, have identified a protein likely responsible for causing breast cancer to spread.

8 Dec 2008

Lupin allergy in children

During her doctoral work, Lise Holden developed a method of identifying lupin protein in food products. She also investigated the incidence of lupin allergy among children with food allergy and studied the proteins in lupin responsible for allergy production.

8 Dec 2008

Glowing imaging compound allows detection of viable cancer cells in mice

Researchers have developed a new type of imaging compound that allows them to visualize viable breast cancer cells that have spread to the lungs in mice.

8 Dec 2008

Rituxan in combination with chemo improves survival in chronic lymphocytic leukemia

Genentech, Inc. and Biogen Idec have announced that two global Phase III studies in chronic lymphocytic leukemia (CLL), CLL8 and REACH, showed Rituxan (rituximab) plus chemotherapy significantly increased the time patients lived without their disease advancing, as defined by the primary endpoint of progression-free survival (PFS), when compared to chemotherapy alone.

8 Dec 2008

Antibody News and Research

Further Reading

Researchers develop universal influenza vaccine for animals

Early-stage breast cancer patients with HER2 positive tumors at increased risk of recurrence

FDA to review Barr Pharmaceutical's BLA for adenovirus type 4 and 7 live oral vaccines

Researchers identify how key mutations occur in human lymphomas

Novavax announces positive results in trial of seasonal influenza VLP (trivalent) vaccine candidate

Enzyme that mutates antibodies also targets cancer-causing gene

Enzyme that mutates antibodies also targets a cancer-causing oncogene

Vaxfectin-formulated H5N1 pandemic influenza achieves T-cell responses and cross-clade reactivity in humans

Mathematical models of adaptive immunity

An enzyme that mutates antibodies also targets a cancer-causing oncogene

Blocking immune receptor molecule improves response to HIV-like virus, prolongs survival in monkeys

Xencor presents data on anti-CD19 and anti-CD40 antibodies

DNA vaccine for SARS achieves neutralizing responses in first U.S. human trial

Vaccine against malaria could be ready in 5 years

Statins do not interfere with Rituximab treatment for lymphomas

Half-dose vaccination in healthy young individuals may be effective in times of vaccine shortage

Discovery of protein that may cause breast cancer to spread

Lupin allergy in children

Glowing imaging compound allows detection of viable cancer cells in mice

Rituxan in combination with chemo improves survival in chronic lymphocytic leukemia

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