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Scientists use new CRISPR gene-editing approach to find paths toward possible HIV cure

Scientists at Northwestern Medicine are using new advances in CRISPR gene-editing technology to uncover new biology that could lead to longer-lasting treatments and new therapeutic strategies for Human Immunodeficiency Virus (HIV).

1 Apr 2022

Research illuminates why immune disorders affect only one of two identical twins

Scientists have long queried the causes of immune disorders in only one of two identical twins with identical genes. New research from the Wellcome Sanger Institute, the Josep Carreras Leukaemia Research Institute in Spain and their collaborators, has found the answer lies in both alterations in immune cell-cell communication and the epigenome, the host of biological processes that regulate how our genes function.

1 Apr 2022

Researchers explore a novel method to isolate monoclonal antibodies from COVID-19 convalescents infected with SARS-CoV-2 variants

Researchers developed a novel high-throughput method to obtain monoclonal antibodies from COVID-19 individuals infected with SARS-CoV-2 ancestral strain Wuhan-Hu-1 and the Beta or Gamma variants.

1 Apr 2022

Study finds COVID-19 convalescent children had more robust humoral immune responses to SARS-CoV-2 than convalescent adults

The work investigated why the children experienced milder COVID-19 illness even after a strong immune response.

1 Apr 2022

Study explores molecular mechanisms underlying SARS-CoV-2 infection of macrophages and the induction of pro-inflammatory cytokines

Researchers examined the role of sialic acid-binding immunoglobulin-type lectins-1, a myeloid cell-specific receptor, in facilitating SARS-CoV-2 infection of ACE2-deficient macrophages and its effect on pro-inflammatory cytokine expression.

1 Apr 2022

Study identifies a new class of monoclonal antibodies that neutralize both alpha and beta coronaviruses

A team of international scientists has recently isolated and characterized pan-coronavirus neutralizing antibodies from individuals with pre-existing immunity against SARS-CoV-2.

1 Apr 2022

Study investigates rapid nanopore whole-genome sequencing approach for identifying genetic variants

In a new study, researchers developed a whole-genome sequencing pipeline based on nanopore technology for the rapid identification of genetic variants.

1 Apr 2022

Study reveals how zinc supports immunity, suggests ways it could be used to improve health

Zinc's immune-boosting properties are well-established, but scientists haven't known exactly how it works.

1 Apr 2022

NIH program provides a real-time risk assessment of variants of SARS-CoV-2

Faculty from the Departments of Microbiology, Medicine Genetics and Genomic Sciences, and Pathology and Molecular Cell-Based Medicine at the Icahn School of Medicine at Mount Sinai play key roles in a National Institutes of Health (NIH) program set up to provide a real-time risk assessment of variants of SARS-CoV-2, the virus that causes COVID-19. The program, called SARS-CoV-2 Assessment of Viral Evolution (SAVE) and described in a paper published March 31 in Nature, assesses how the variants might affect transmission, virulence, and resistance to both disease-induced (convalescent) and vaccine-induced immunity.

31 Mar 2022

Therapeutic antibodies against filoviruses including Ebola and Marburg

Researchers discuss the development and structural characterization of therapeutic monoclonal antibodies targeting the surface glycoprotein of filoviruses.

31 Mar 2022

The longest duration of SARS-CoV-2 positivity after initial diagnosis

An immunocompetent individual with prolonged SARS-CoV-2 shedding 221 days after their initial COVID-19 diagnosis.

31 Mar 2022

The mucosal antibody response to SARS-CoV-2

Researchers determine mucosal SARS-CoV-2-specific antibody levels and their neutralizing effect in pediatric and adult patients.

31 Mar 2022

How effective are household cleaning agents against SARS-CoV-2?

Researchers analyze commonly available household cleaning products to determine the most effective virucidal agent against SARS-CoV-2.

31 Mar 2022

The evolution of the SARS-CoV-2 spike protein

Researchers discuss the evolution and mechanisms of mutations that have occurred in the spike protein of SARS-CoV-2.

31 Mar 2022

UW Medicine scientists contribute to the publication of first complete, gapless genome sequence

UW Medicine genome scientists were among the leading contributors to the publication of the first complete, gapless sequence of a human genome announced this week by the National Human Genome Research Institute.

31 Mar 2022

Virginia Tech researcher awarded $1.9 million grant to study about mitophagy

Most of us remember enough biology to recall that mitochondria are known as "the powerhouse of the cell." Even that audacious term may downplay the importance of mitochondria and what happens when mitochondria go bad.

31 Mar 2022

Scientists explore impact of SARS-CoV-2 natural immunity on vaccine-induced immunity

A new study investigated the impact of pre-existing SARS-CoV-2 infection-induced immunity on vaccine-induced immunity.

31 Mar 2022

3D Printing Testicular Cells to Treat Infertility

In this interview, we speak to Dr. Ryan Flannigan about his latest research that involved the 3D printing of sperm cells to help treat male infertility.

31 Mar 2022

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

A new study identified mechanisms regulating immune cell plasticity to develop new therapeutics.

31 Mar 2022

Study determines the molecular signatures of monocytes and regulatory T cells in the circulating blood of COVID-19 patients

Researchers examined the unique clusters of monocytes and regulatory T cells in the circulating blood from convalescent COVID-19 patients over a prolonged period after recovery, using scRNA sequencing.

31 Mar 2022

B Cell News and Research

Scientists use new CRISPR gene-editing approach to find paths toward possible HIV cure

Research illuminates why immune disorders affect only one of two identical twins

Researchers explore a novel method to isolate monoclonal antibodies from COVID-19 convalescents infected with SARS-CoV-2 variants

Study finds COVID-19 convalescent children had more robust humoral immune responses to SARS-CoV-2 than convalescent adults

Study explores molecular mechanisms underlying SARS-CoV-2 infection of macrophages and the induction of pro-inflammatory cytokines

Study identifies a new class of monoclonal antibodies that neutralize both alpha and beta coronaviruses

Study investigates rapid nanopore whole-genome sequencing approach for identifying genetic variants

Study reveals how zinc supports immunity, suggests ways it could be used to improve health

NIH program provides a real-time risk assessment of variants of SARS-CoV-2

Therapeutic antibodies against filoviruses including Ebola and Marburg

The longest duration of SARS-CoV-2 positivity after initial diagnosis

The mucosal antibody response to SARS-CoV-2

How effective are household cleaning agents against SARS-CoV-2?

The evolution of the SARS-CoV-2 spike protein

UW Medicine scientists contribute to the publication of first complete, gapless genome sequence

Virginia Tech researcher awarded $1.9 million grant to study about mitophagy

Scientists explore impact of SARS-CoV-2 natural immunity on vaccine-induced immunity

3D Printing Testicular Cells to Treat Infertility

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

Study determines the molecular signatures of monocytes and regulatory T cells in the circulating blood of COVID-19 patients

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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