Clinical Trial News and Research

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Vorinostat reduces risk of graft-vs.-host disease from bone marrow transplant treatments

A new class of drugs reduced the risk of patients contracting a serious and often deadly side effect of lifesaving bone marrow transplant treatments, according to a study from researchers at the University of Michigan Comprehensive Cancer Center.

10 Dec 2012

Results from eribulin and capecitabine phase III comparison trial on metastatic breast cancer

Results from a phase III clinical trial comparing a newer chemotherapy agent called eribulin mesylate with capecitabine, a standard drug used for chemotherapy today in women with previously treated metastatic breast cancer, showed that eribulin demonstrated a trend toward improved overall survival.

10 Dec 2012

Ipsen, Active Biotech complete enrollment in tasquinimod Phase III trial for prostate cancer

Active Biotech and Ipsen today announced that the Phase III clinical trial for tasquinimod, a novel compound for the treatment of prostate cancer, is successfully enrolled with over 1,200 randomized patients as planned in the clinical protocol.

10 Dec 2012

Angiocidin reduces acute myeloid leukemia cells in vivo by almost two-thirds in pre-clinical studies

Angiocidin, a novel tumor-inhibiting protein, has been shown to reduce acute myeloid leukemia (AML) cells in vivo by almost two-thirds in pre-clinical experiments.

10 Dec 2012

GSK, MD Anderson partner to develop new therapeutic antibodies against cancer

The University of Texas MD Anderson Cancer Center and GlaxoSmithKline (GSK) have signed a research collaboration and license agreement to develop new therapeutic antibodies that promote an immune system attack against cancer.

10 Dec 2012

Novel antidepressant targets brain receptors responsible for learning and memory

A first-of-its-kind antidepressant drug discovered by a Northwestern University professor and now tested on adults who have failed other antidepressant therapies has been shown to alleviate symptoms within hours, have good safety and produce positive effects that last for about seven days from a single dose.

7 Dec 2012

IRIN examines WHO's efforts to communicate HIV risk among injectable hormonal contraceptive users

IRIN examines the WHO's ongoing efforts to synthesize and communicate guidance about the risk of HIV infection and transmission for women taking injectable hormonal contraception, including a meeting scheduled for this week in Geneva.

7 Dec 2012

Naurex reports positive results from GLYX-13 Phase IIa trial on depression

Naurex Inc., a clinical-stage company developing innovative treatments to address unmet needs in psychiatry and neurology, today reported positive results from a Phase IIa clinical trial of its lead antidepressant compound, GLYX-13.

6 Dec 2012

Bio-Path to initiate BP-100-1.01 Phase I trial for treatment of two types of breast cancer

Bio-Path Holdings, Inc., a biotechnology company developing a liposomal delivery technology for nucleic acid cancer drugs, today announced it is initiating development of its lead cancer drug BP-100-1.01 (Liposomal Grb-2) to treat triple negative breast cancer (TNBC) and inflammatory breast cancer (IBC), two cancers characterized by formation of aggressive tumors and relatively high mortality rates.

6 Dec 2012

RedHill Biopharma completes $6.5M private placement

RedHill Biopharma Ltd., an Israeli biopharmaceutical company focusing primarily on development and acquisition of late clinical stage, patent-protected, new formulations and combinations of existing drugs, reported the completion of a private placement in a total amount of approximately $6.5 million.

6 Dec 2012

Scancell announces preliminary results from Part 1 of ImmunoBody vaccine Phase 1/2 MM trial

Scancell Holdings Plc, the developer of therapeutic cancer vaccines, is pleased to announce preliminary results from Part 1 of the Phase 1/2 clinical trial of its DNA ImmunoBody vaccine in patients with Stage III/IV malignant melanoma.

6 Dec 2012

$Orthoses improve pain, balance in fracture-prone elderly$

Orthoses improve pain, balance in fracture-prone elderly

Short-term use of foot orthoses reduces pain and disability in elderly women with osteoporosis, results of a randomized clinical trial indicate.

6 Dec 2012

Using Nanoparticles to Target Cancer

An interview with John Stroh, discussing the development of nanoparticles that can target and treat cancer, without damaging nearby tissues.

6 Dec 2012

Investigators describe process by which apoE4 protein promotes development of Alzheimer's

Despite researchers' best efforts, no drug exists that can slow, halt or reverse the onslaught of Alzheimer's disease. A progressive and fatal neurodegenerative disorder, Alzheimer's has stolen the memories and livelihoods of millions-leaving patients and their families struggling to cope with the disease's devastating consequences. But today, scientists at the Gladstone Institutes propose a new research avenue that has the potential to change all that.

6 Dec 2012

Clinical trial to explore Lose It! App for postpartum weight loss

In a first-of-its-kind clinical trial, physician-researchers at University Hospitals (UH) Case Medical Center MacDonald Women's Hospital are exploring the use of "Lose It!," a free Smartphone application (app), for postpartum weight loss.

6 Dec 2012

First U.S. patient treated with deep brain stimulation for Alzheimer's at Johns Hopkins

Researchers at Johns Hopkins Medicine in November surgically implanted a pacemaker-like device into the brain of a patient in the early stages of Alzheimer's disease, the first such operation in the United States. The device, which provides deep brain stimulation and has been used in thousands of people with Parkinson's disease, is seen as a possible means of boosting memory and reversing cognitive decline.

6 Dec 2012

Rice bran offers promising cancer prevention properties

A recent University of Colorado Cancer Center review in the journal Advances in Nutrition shows that rice bran offers promising cancer prevention properties. Meanwhile, an ongoing clinical trial is testing the effectiveness of rice bran in preventing the recurrence of colon cancer.

6 Dec 2012

New prenatal genetic test results in more clinically relevant information

A large, multi-center clinical trial led by researchers from Columbia University Medical Center (CUMC) shows that a new genetic test resulted in significantly more clinically relevant information than the current standard method of prenatal testing.

6 Dec 2012

Tenofovir DF safe and effective in treating adolescents with HBV

A recent clinical trial found that the adult antiviral drug, tenofovir disoproxil fumarate (tenofovir DF), is safe and effective in treating adolescents with hepatitis B virus (HBV). Trial results published in the December issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD), show that tenofovir DF suppressed HBV in 89% of pediatric participants.

6 Dec 2012

University of Florida initiates enrollment in SPI-1005 Phase II trial for sensorineural hearing loss

The University of Florida (UF) has started enrolling subjects in a new study testing the oral drug developed by Sound Pharmaceuticals, Inc. (SPI-1005) to prevent hearing loss caused by loud music. Loud music or noise can induce temporary and permanent auditory threshold shifts (TTS or PTS).

6 Dec 2012

Clinical Trial News and Research

Vorinostat reduces risk of graft-vs.-host disease from bone marrow transplant treatments

Results from eribulin and capecitabine phase III comparison trial on metastatic breast cancer

Ipsen, Active Biotech complete enrollment in tasquinimod Phase III trial for prostate cancer

Angiocidin reduces acute myeloid leukemia cells in vivo by almost two-thirds in pre-clinical studies

GSK, MD Anderson partner to develop new therapeutic antibodies against cancer

Novel antidepressant targets brain receptors responsible for learning and memory

IRIN examines WHO's efforts to communicate HIV risk among injectable hormonal contraceptive users

Naurex reports positive results from GLYX-13 Phase IIa trial on depression

Bio-Path to initiate BP-100-1.01 Phase I trial for treatment of two types of breast cancer

RedHill Biopharma completes $6.5M private placement

Scancell announces preliminary results from Part 1 of ImmunoBody vaccine Phase 1/2 MM trial

Orthoses improve pain, balance in fracture-prone elderly

Using Nanoparticles to Target Cancer

Investigators describe process by which apoE4 protein promotes development of Alzheimer's

Clinical trial to explore Lose It! App for postpartum weight loss

First U.S. patient treated with deep brain stimulation for Alzheimer's at Johns Hopkins

Rice bran offers promising cancer prevention properties

New prenatal genetic test results in more clinically relevant information

Tenofovir DF safe and effective in treating adolescents with HBV

University of Florida initiates enrollment in SPI-1005 Phase II trial for sensorineural hearing loss

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