Clinical Trial News and Research

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TB vaccine candidate trial results are 'landmark' in fight against disease

"Today marks an important landmark for the fight against tuberculosis (TB)," with the publication in the Lancet of clinical trial results showing the TB vaccine candidate MVA85A "was no more effective in protecting infants from developing pulmonary TB than" the standard Bacillus Calmette-Guerin (BCG) vaccine, Peggy Johnston, senior program officer at the Bill & Melinda Gates Foundation, writes in the foundation's "Impatient Optimists" blog.

6 Feb 2013

Researchers assess complete landscape of kinome expression in cancer

When it comes to gene sequencing and personalized medicine for cancer, spotting an aberrant kinase is a home run. The proteins are relatively easy to target with drugs and plenty of kinase inhibitors already exist.

6 Feb 2013

ZOLL's Intravascular Temperature Management solution receives Shonin approval in Japan

ZOLL Medical Corporation, a manufacturer of medical devices and related software solutions, has received Shonin approval from the Japanese Ministry of Health, Labour and Welfare (MHLW) to enter the Japanese market with its Intravascular Temperature Management (IVTM) technology—the first intravascular temperature management system to receive Shonin approval in Japan.

6 Feb 2013

Verastem commences VS-6063 plus paclitaxel Phase 1/1b trial in advanced ovarian cancer

Verastem, Inc., a clinical-stage biopharmaceutical company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced the initiation of a Phase 1/1b trial of VS-6063 in combination with paclitaxel for the treatment of advanced ovarian cancer.

5 Feb 2013

Acceleron commences dalantercept phase 2 study in metastatic renal cell carcinoma

Acceleron Pharma, Inc., a biopharmaceutical company developing protein therapeutics for cancer and orphan diseases, announced the initiation of a phase 2 study of dalantercept, a novel angiogenesis inhibitor that targets the activin receptor-like kinase 1 (ALK1) pathway.

5 Feb 2013

Acceleron Pharma initiates dalantercept phase 2 study in advanced ovarian cancer

Acceleron Pharma, a biopharmaceutical company developing protein therapeutics for cancer and orphan disease, today announced that the Gynecologic Oncology Group (GOG) initiated a phase 2 study of dalantercept in patients with persistent or recurrent ovarian, fallopian tube, or primary peritoneal cancer.

5 Feb 2013

Researchers pinpoint how vitamin D3 and omega-3 may boost immunity to help fight Alzheimer's

A team of academic researchers has pinpointed how vitamin D3 and omega-3 fatty acids may enhance the immune system's ability to clear the brain of amyloid plaques, one of the hallmarks of Alzheimer's disease.

5 Feb 2013

Viral conjunctivitis: potential new treatment

Viral conjunctivitis is a highly contagious infection, often causing major ophthalmic epidemics. There is no approved acute treatment currently approved by the FDA for viral conjunctivitis. A safe broad-spectrum antiviral agent is needed to treat this unmet medical need.

5 Feb 2013

GLP-1 receptor agonists associated with reduced BMI in adolescents with severe obesity

Preliminary evidence from a clinical trial suggests that treatment with glucagon-like peptide-1 (GLP-1) receptor agonists was associated with reduced body mass index and body weight in adolescents with severe obesity, according to a report published Online First by JAMA Pediatrics, a JAMA Network publication.

5 Feb 2013

Results from Merck’s Vorinostat phase 1 trial on lymphoma

Patients whose aggressive lymphomas have relapsed or failed to respond to the current front-line chemotherapy regimen now have an effective second line of attack against their disease.

5 Feb 2013

St. Jude Medical initiates Portico Transfemoral European Trial in severe aortic stenosis

St. Jude Medical, Inc., a global medical device company, today announced the first patient implant of its 25 mm Portico Transcatheter Aortic Heart Valve using the Transfemoral Delivery System in its ongoing European trial.

5 Feb 2013

Gilead Sciences fourth quarter total revenues increase 18% to $2.59 billion

Gilead Sciences, Inc. announced today its results of operations for the fourth quarter and full year 2012.

5 Feb 2013

BrainStorm initiates NurOwn Phase IIa dose-escalating trial in ALS

BrainStorm Cell Therapeutics, a leading developer of adult stem cell technologies for neurodegenerative diseases, announced today that the first patient began treatment in the Company's Phase IIa dose-escalating clinical trial for ALS.

5 Feb 2013

Reduced dose of polio vaccine feasible in low-income areas

Vaccinating infants with a single fractional dose of inactivated poliovirus is an effective and more affordable alternative to using multiple full doses, report researchers in the New England Journal of Medicine.

4 Feb 2013

Mood disorder clinics improve bipolar disorder outcomes

Early treatment of patients with bipolar disorder in a specialized mood disorder clinic substantially reduces the risk for readmission to a psychiatric hospital, clinical trial findings show.

4 Feb 2013

Indian medicines ‘promising’ for osteoarthritis care

Ayurvedic medicine may offer osteoarthritis relief, say Indian researchers who found traditional formulations to be equal to conventional drugs for the improvement of pain and knee function.

4 Feb 2013

Researchers await clinical trial results of potential TB vaccine, expected early next week

"After nearly 100 years, researchers could be on the verge of finding a vaccine that would eradicate tuberculosis [TB] infections," Reuters reports, noting, "Global health experts are eagerly awaiting clinical trial results, expected early next week, of the first new vaccine in 90 years designed to prevent tuberculosis infections."

2 Feb 2013

Researchers identify 7 factors to lessen radiation exposure in young, traumatic injury victims

A study of more than 12,000 children from emergency departments throughout the country in the Pediatric Emergency Care Applied Research Network (PECARN) has identified seven factors that can help physicians determine the need for a computed tomography (CT) scan following blunt trauma to the abdomen.

2 Feb 2013

Galectin submits GR-MD-02 IND application with FDA for treatment of liver fibrosis

Galectin Therapeutics, the leading developer of therapeutics that target galectin proteins to treat fibrosis and cancer, announced today that it submitted an Investigational New Drug (IND) application to the US Food and Drug Administration (FDA) on January 30, 2013.

1 Feb 2013

FDA allows Arteriocyte to commence Magellan System Phase I trial in thermal burn wounds

Arteriocyte, a leading biotechnology company with offices in Cleveland, Ohio and Hopkinton, Massachusetts announced today approval from the Food and Drug Administration (FDA) to initiate a Phase I clinical trial using its Magellan System technology in the treatment of thermal burn wounds.

31 Jan 2013

Clinical Trial News and Research

TB vaccine candidate trial results are 'landmark' in fight against disease

Researchers assess complete landscape of kinome expression in cancer

ZOLL's Intravascular Temperature Management solution receives Shonin approval in Japan

Verastem commences VS-6063 plus paclitaxel Phase 1/1b trial in advanced ovarian cancer

Acceleron commences dalantercept phase 2 study in metastatic renal cell carcinoma

Acceleron Pharma initiates dalantercept phase 2 study in advanced ovarian cancer

Researchers pinpoint how vitamin D3 and omega-3 may boost immunity to help fight Alzheimer's

Viral conjunctivitis: potential new treatment

GLP-1 receptor agonists associated with reduced BMI in adolescents with severe obesity

Results from Merck’s Vorinostat phase 1 trial on lymphoma

St. Jude Medical initiates Portico Transfemoral European Trial in severe aortic stenosis

Gilead Sciences fourth quarter total revenues increase 18% to $2.59 billion

BrainStorm initiates NurOwn Phase IIa dose-escalating trial in ALS

Reduced dose of polio vaccine feasible in low-income areas

Mood disorder clinics improve bipolar disorder outcomes

Indian medicines ‘promising’ for osteoarthritis care

Researchers await clinical trial results of potential TB vaccine, expected early next week

Researchers identify 7 factors to lessen radiation exposure in young, traumatic injury victims

Galectin submits GR-MD-02 IND application with FDA for treatment of liver fibrosis

FDA allows Arteriocyte to commence Magellan System Phase I trial in thermal burn wounds

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